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1821Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheeppor Jacobson, Gregory M., Kraakman, Kirsty, Wallace, Olivia, Pan, Jolyn, Hennebry, Alex, Smolenski, Grant, Cursons, Ray, Hodgkinson, Steve, Williamson, Adele, Kelton, William“…Here we show that the immunization of sheep with fusions of the SARS-CoV-2 receptor binding domain (RBD) to ovine IgG2a Fc domains promotes significantly higher levels of antigen-specific antibodies compared to native RBD or full-length spike antigens. …”
Publicado 2023
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1822por Vinh, Donald C, Gouin, Jean-Philippe, Cruz-Santiago, Diana, Canac-Marquis, Michelle, Bernier, Stéphane, Bobeuf, Florian, Sengupta, Avik, Brassard, Jean-Philippe, Guerra, Alyssa, Dziarmaga, Robert, Perez, Anna, Sun, Yichun, Li, Yongbiao, Roussel, Lucie, Langelier, Mélanie J, Ke, Danbing, Arnold, Corey, Whelan, Marilyn, Pelchat, Martin, Langlois, Marc-André, Zhang, Xun, Mazer, Bruce D“…In the discovery cohort, after a significant increase in anti-RBD and anti-spike IgG concentrations 4 weeks after the prime dose (from 4·86 log binding antibody units [BAU]/mL to 8·53 log BAU/mL for anti-RBD IgG and from 5·21 log BAU/mL to 8·05 log BAU/mL for anti-spike IgG), there was a significant decline in anti-RBD and anti-spike IgG concentrations until the boost dose (7·10 log BAU/mL for anti-RBD IgG and 7·60 log BAU/mL for anti-spike IgG), followed by an increase 4 weeks later for both vaccines (9·58 log BAU/mL for anti-RBD IgG and 9·23 log BAU/mL for anti-spike IgG). …”
Publicado 2022
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1823por Zhu, Fengcai, Zhuang, Chunlan, Chu, Kai, Zhang, Liang, Zhao, Hui, Huang, Shoujie, Su, Yingying, Lin, Hongyan, Yang, Changlin, Jiang, Hanmin, Zang, Xia, Liu, Donglin, Pan, Hongxing, Hu, Yuemei, Liu, Xiaohui, Chen, Qi, Song, Qiaoqiao, Quan, Jiali, Huang, Zehong, Zhong, Guohua, Chen, Junyu, Han, Jinle, Sun, Hong, Cui, Lunbiao, Li, Jingxin, Chen, Yixin, Zhang, Tianying, Ye, Xiangzhong, Li, Changgui, Wu, Ting, Zhang, Jun, Xia, Ning-Shao“…We aimed to evaluate the safety and immunogenicity of a live-attenuated influenza virus vector-based SARS-CoV-2 vaccine (dNS1-RBD) administered by intranasal spray in healthy adults. …”
Publicado 2022
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1824por Yan, Shijun, Jiang, Cheng, Janzen, Annette, Barber, Thomas R., Seger, Aline, Sommerauer, Michael, Davis, Jason J., Marek, Kenneth, Hu, Michele T., Oertel, Wolfgang H., Tofaris, George K.“…The derivation group (n = 170) included participants with isolated rapid eye movement sleep behavior disorder (iRBD) and controls. Two validation groups were used: the first (n = 122) included participants with iRBD and controls and the second (n = 263) included nonmanifest GBA1(N409S) gene carriers, participants with iRBD or hyposmia, and available dopamine transporter single-photon emission computed tomography, healthy controls, and patients with sporadic PD. …”
Publicado 2023
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1825por Postuma, Ronald B, Iranzo, Alex, Hu, Michele, Högl, Birgit, Boeve, Bradley F, Manni, Raffaele, Oertel, Wolfgang H, Arnulf, Isabelle, Ferini-Strambi, Luigi, Puligheddu, Monica, Antelmi, Elena, Cochen De Cock, Valerie, Arnaldi, Dario, Mollenhauer, Brit, Videnovic, Aleksandar, Sonka, Karel, Jung, Ki-Young, Kunz, Dieter, Dauvilliers, Yves, Provini, Federica, Lewis, Simon J, Buskova, Jitka, Pavlova, Milena, Heidbreder, Anna, Montplaisir, Jacques Y, Santamaria, Joan, Barber, Thomas R, Stefani, Ambra, St.Louis, Erik K, Terzaghi, Michele, Janzen, Annette, Leu-Semenescu, Smandra, Plazzi, Guiseppe, Nobili, Flavio, Sixel-Doering, Friederike, Dusek, Petr, Bes, Frederik, Cortelli, Pietro, Ehgoetz Martens, Kaylena, Gagnon, Jean-Francois, Gaig, Carles, Zucconi, Marco, Trenkwalder, Claudia, Gan-Or, Ziv, Lo, Christine, Rolinski, Michal, Mahlknecht, Philip, Holzknecht, Evi, Boeve, Angel R, Teigen, Luke N, Toscano, Gianpaolo, Mayer, Geert, Morbelli, Silvia, Dawson, Benjamin, Pelletier, Amelie“…Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. …”
Publicado 2019
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1826por Hamm, Sebastian Rask, Møller, Dina Leth, Pérez-Alós, Laura, Hansen, Cecilie Bo, Pries-Heje, Mia Marie, Heftdal, Line Dam, Hasselbalch, Rasmus Bo, Fogh, Kamille, Madsen, Johannes Roth, Almagro Armenteros, Jose Juan, Knudsen, Andreas Dehlbæk, Poulsen, Johan Runge, Frikke-Schmidt, Ruth, Hilsted, Linda Maria, Sørensen, Erik, Ostrowski, Sisse Rye, Harboe, Zitta Barrella, Perch, Michael, Sørensen, Søren Schwartz, Rasmussen, Allan, Bundgaard, Henning, Garred, Peter, Iversen, Kasper, Nielsen, Susanne Dam“…At all time points, anti-RBD IgG was lower in SOT recipients than that in controls. …”
Publicado 2022
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1827por Guillen, G., Limonta, M., Muzio, V., Lemos, G., Hernández-Bernal, F., Chinea, G., Gonzalez-Roche, D., Martin, A., Bequet, M., Marques, G., Zamora, J., Brito, J., Enriquez-Puertas, J., Cruz-Sui, O., Noa, E., Gonzalez-Sosa, N., Dubed, M., Valdibia, I., Palenzuela, A., Valdes, J., Carlos-Pia, N., Rodriguez, M., Ayala, M., Pimentel, E., Martinez, E.“…The RBD to ACE2 plate-based binding competitive ELISA was performed to determine the inhibitory activity of the anti-RBD polyclonal sera on the binding of the hFc-ACE2 coated plates. …”
Publicado 2023
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1828por Janardanan, Sarosh, Nigam, Anurag, Moschonas, Dimitrios, Perry, Matthew, Patil, Krishna“…Patients who were diagnosed with cancer in the diverticulum, associated pathology that may contribute to their symptoms, or who had concomitant procedures at the time of RBD were excluded from this study. Results We had six patients who underwent RBD; the median age and body mass index (BMI) were 63.8 years (range 48-73) and 27.1 kg/m(2 )(range 24-32), respectively. …”
Publicado 2023
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1829por Pflumm, Dominik, Seidel, Alina, Klein, Fabrice, Groß, Rüdiger, Krutzke, Lea, Kochanek, Stefan, Kroschel, Joris, Münch, Jan, Stifter, Katja, Schirmbeck, Reinhold“…The trimeric S2-P antigen induced high S-RBD-specific antibody responses in old (23-24 months) mice through DNA-prime/DNA-boost vaccination. …”
Publicado 2023
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1830por Puro, Vincenzo, Castilletti, Concetta, Agrati, Chiara, Goletti, Delia, Leone, Sara, Agresta, Alessandro, Cimini, Eleonora, Tartaglia, Eleonora, Casetti, Rita, Colavita, Francesca, Meschi, Silvia, Matusali, Giulia, Lapa, Daniele, Najafi Fard, Saeid, Aiello, Alessandra, Farrone, Chiara, Gallì, Paola, Capobianchi, Maria Rosaria, Ippolito, Giuseppe“…Female workers showed an 81% MNA and a 44% anti-S/RBD increase compared to male workers (p < 0.001). …”
Publicado 2021
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1831por Chen, Liang, Zody, Michael C., Di Germanio, Clara, Martinelli, Rachel, Mediavilla, Jose R., Cunningham, Marcus H., Composto, Kaelea, Chow, Kar Fai, Kordalewska, Milena, Corvelo, André, Oschwald, Dayna M., Fennessey, Samantha, Zetkulic, Marygrace, Dar, Sophia, Kramer, Yael, Mathema, Barun, Germer, Soren, Stone, Mars, Simmons, Graham, Busch, Michael P., Maniatis, Tom, Perlin, David S., Kreiswirth, Barry N.“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), harboring spike protein N-terminal domain (NTD) or receptor-binding domain (RBD) mutations, exhibit reduced in vitro susceptibility to convalescent-phase serum, commercial antibody cocktails, and vaccine neutralization and have been associated with reinfections. …”
Publicado 2021
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1832por Pace, Ryan M., Williams, Janet E., Järvinen, Kirsi M., Meehan, Courtney L., Martin, Melanie A., Ley, Sylvia H., Barbosa-Leiker, Celestina, Andres, Aline, Yeruva, Laxmi, Belfort, Mandy B., Caffé, Beatrice, Navarrete, Alexandra D., Lackey, Kimberly A., Pace, Christina D. W., Gogel, Alexandra C., Fehrenkamp, Bethaney D., Klein, Miranda, Young, Bridget E., Rosen-Carole, Casey, Diaz, Nichole, Gaw, Stephanie L., Flaherman, Valerie, McGuire, Mark A., McGuire, Michelle K., Seppo, Antti E.“…Milk-borne anti-RBD IgA persisted for at least two months in 77% of women. …”
Publicado 2021
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1833por Gressens, Simon B., Fourati, Slim, Le Bouter, Anne, Le Bras, Fabien, Dupuis, Jehan, Hammoud, Mohammad, El Gnaoui, Taoufik, Gounot, Romain, Roulin, Louise, Belhadj, Karim, Haioun, Corinne, Gallien, Sébastien, Melica, Giovanna, Lemonnier, François“…The seroconversion rate and antibody concentrations increased significantly, especially in patients with plasma cell disorders, where an increment of anti-RBD IgG concentrations was observed in 31 of 44 (70%) patients, with an anti-RBD concentration median-fold increase of 10.6 (IQR 2.4–25.5). …”
Publicado 2022
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1834por Rouhani, Sherin Juliet, Yu, Jovian, Olson, Daniel, Zha, Yuanyuan, Pezeshk, Apameh, Cabanov, Alexandra, Pyzer, Athalia R, Trujillo, Jonathan, Derman, Benjamin A, O'Donnell, Peter, Jakubowiak, Andrzej, Kindler, Hedy L, Bestvina, Christine, Gajewski, Thomas F“…METHODS: Antibodies to the SARS-CoV-2 receptor binding domain (RBD) and spike protein were assessed in patients with cancer (n=118) and healthy donors (HD, n=22) after 1, 2 or 3 mRNA vaccine doses. …”
Publicado 2022
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1835por Mitchell, Kaitlin F., Carlson, Christina M., Nace, Douglas, Wakeman, Brian S., Drobeniuc, Jan, Niemeyer, Glenn P., Werner, Bonnie, Hoffmaster, Alex R., Satheshkumar, Panayampalli S., Schuh, Amy J., Udhayakumar, Venkatachalam, Rogier, Eric“…Human serum specimens (n = 323) with known previous SARS-CoV-2 exposure status were tested on a commercially available multiplex bead assay (MBA) measuring IgG to SARS-CoV-2 spike protein receptor-binding domain (RBD), nucleocapsid protein (NP), and RBD/NP fusion antigens. …”
Publicado 2022
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1836por Li, Ruofan, Mor, Michael, Ma, Bingting, Clark, Alex E., Alter, Joel, Werbner, Michal, Lee, Jamie Casey, Leibel, Sandra L., Carlin, Aaron F., Dessau, Moshe, Gal-Tanamy, Meital, Croker, Ben A., Xiang, Ye, Freund, Natalia T.“…We solve the structures of the Delta-neutralizing ACE2bs mAb TAU-2303 with the SARS-CoV-2 spike trimer and RBD at 4.5 Å and 2.42 Å resolutions, respectively, revealing a similar mode of binding to that between the RBD and ACE2. …”
Publicado 2022
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1837por Ailsworth, Samuel M., Keshavarz, Behnam, Richards, Nathan E., Workman, Lisa J., Murphy, Deborah D., Nelson, Michael R., Platts-Mills, Thomas A.E., Wilson, Jeffrey M.“…We also compared S-RBD IgG levels after BNT162b2 and mRNA-1273 boosters and explored effects of age and prior infection. …”
Publicado 2023
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1838por Chen, Wei-Hung, Hajduczki, Agnes, Martinez, Elizabeth J., Bai, Hongjun, Matz, Hanover, Hill, Thomas M., Lewitus, Eric, Chang, William C., Dawit, Layla, Peterson, Caroline E., Rees, Phyllis A., Ajayi, Adelola B., Golub, Emily S., Swafford, Isabella, Dussupt, Vincent, David, Sapna, Mayer, Sandra V., Soman, Sandrine, Kuklis, Caitlin, Corbitt, Courtney, King, Jocelyn, Choe, Misook, Sankhala, Rajeshwer S., Thomas, Paul V., Zemil, Michelle, Wieczorek, Lindsay, Hart, Tricia, Duso, Debora, Kummer, Larry, Yan, Lianying, Sterling, Spencer L., Laing, Eric D., Broder, Christopher C., Williams, Jazmean K., Davidson, Edgar, Doranz, Benjamin J., Krebs, Shelly J., Polonis, Victoria R., Paquin-Proulx, Dominic, Rolland, Morgane, Reiley, William W., Gromowski, Gregory D., Modjarrad, Kayvon, Dooley, Helen, Joyce, M. Gordon“…Here we show that nurse sharks immunized with SARS-CoV-2 recombinant receptor binding domain (RBD), RBD-ferritin (RFN), or spike protein ferritin nanoparticle (SpFN) immunogens elicit a set of new antigen receptor antibody (IgNAR) molecules that target two non-overlapping conserved epitopes on the spike RBD. …”
Publicado 2023
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1839por Shi, Meng, Zhao, Jiaqi, Zhang, Simin, Huang, Wei, Li, Mengfei, Bai, Xue, Zhang, Wenxue, Zhang, Kai, Chen, Xuefeng, Xiang, Song“…Here, we present crystal structure of the Bre1 RBD–Rad6 complex and structure-guided functional studies. …”
Publicado 2023
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1840por Quagliata, Michael, Stincarelli, Maria Alfreda, Papini, Anna Maria, Giannecchini, Simone, Rovero, Paolo“…The infection pathway starts when the receptor binding domain of the viral spike protein interacts with the angiotensin converting enzyme 2 (ACE2), which acts as a host receptor for the RBD expressed on the host cell surface. In this scenario, ACE2 analogs binding to the RBD and preventing the cell entry can be promising antiviral agents. …”
Publicado 2023
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