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1881por Mercurio, Ivan, Tragni, Vincenzo, Busto, Francesco, De Grassi, Anna, Pierri, Ciro Leonardo“…More in general, our analysis provides indications for the set-up of the right biological molecular context for investigating spike RBD–ACE2 interactions for the development of new vaccines, diagnostic kits, and other treatments based on the targeting of SARS-CoV-2 spike protein. …”
Publicado 2020
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1882por Robbiani, Davide F., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. C., Wang, Zijun, Cho, Alice, Agudelo, Marianna, Barnes, Christopher O., Gazumyan, Anna, Finkin, Shlomo, Hägglöf, Thomas, Oliveira, Thiago Y., Viant, Charlotte, Hurley, Arlene, Hoffmann, Hans-Heinrich, Millard, Katrina G., Kost, Rhonda G., Cipolla, Melissa, Gordon, Kristie, Bianchini, Filippo, Chen, Spencer T., Ramos, Victor, Patel, Roshni, Dizon, Juan, Shimeliovich, Irina, Mendoza, Pilar, Hartweger, Harald, Nogueira, Lilian, Pack, Maggi, Horowitz, Jill, Schmidt, Fabian, Weisblum, Yiska, Michailidis, Eleftherios, Ashbrook, Alison W., Waltari, Eric, Pak, John E., Huey-Tubman, Kathryn E., Koranda, Nicholas, Hoffman, Pauline R., West, Anthony P., Rice, Charles M., Hatziioannou, Theodora, Bjorkman, Pamela J., Bieniasz, Paul D., Caskey, Marina, Nussenzweig, Michel C.“…Virus entry into cells depends on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S). Although there is no vaccine, it is likely that antibodies will be essential for protection. …”
Publicado 2020
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1883por Bušková, Jitka, Miletínová, Eva, Kliková, Monika, Bareš, Martin, Novák, Tomáš, Kosová, Jiřina, Stopková, Pavla, Kopřivová, Jana“…BACKGROUND: Isolated REM sleep without atonia (RSWA) as a main polysomnograhic feature of REM sleep behaviour disorder (RBD) is thought to be a prodromal or subclinical state of the disease. …”
Publicado 2020
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1884por Ripperger, Tyler J., Uhrlaub, Jennifer L., Watanabe, Makiko, Wong, Rachel, Castaneda, Yvonne, Pizzato, Hannah A., Thompson, Mallory R., Bradshaw, Christine, Weinkauf, Craig C., Bime, Christian, Erickson, Heidi L., Knox, Kenneth, Bixby, Billie, Parthasarathy, Sairam, Chaudhary, Sachin, Natt, Bhupinder, Cristan, Elaine, El Aini, Tammer, Rischard, Franz, Campion, Janet, Chopra, Madhav, Insel, Michael, Sam, Afshin, Knepler, James L., Capaldi, Andrew P., Spier, Catherine M., Dake, Michael D., Edwards, Taylor, Kaplan, Matthew E., Scott, Serena Jain, Hypes, Cameron, Mosier, Jarrod, Harris, David T., LaFleur, Bonnie J., Sprissler, Ryan, Nikolich-Žugich, Janko, Bhattacharya, Deepta“…Testing 5,882 members of the local community revealed only 1 sample with seroreactivity to both RBD and S2 that lacked neutralizing antibodies. …”
Publicado 2020
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1885por Glasgow, Anum, Glasgow, Jeff, Limonta, Daniel, Solomon, Paige, Lui, Irene, Zhang, Yang, Nix, Matthew A., Rettko, Nicholas J., Zha, Shoshana, Yamin, Rachel, Kao, Kevin, Rosenberg, Oren S., Ravetch, Jeffrey V., Wiita, Arun P., Leung, Kevin K., Lim, Shion A., Zhou, Xin X., Hobman, Tom C., Kortemme, Tanja, Wells, James A.“…We first computationally designed the ACE2–RBD interface using a two-stage flexible protein backbone design process that improved affinity for the RBD by up to 12-fold. …”
Publicado 2020
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1886por Zhou, Tongqing, Tsybovsky, Yaroslav, Gorman, Jason, Rapp, Micah, Cerutti, Gabriele, Chuang, Gwo-Yu, Katsamba, Phinikoula S., Sampson, Jared M., Schön, Arne, Bimela, Jude, Boyington, Jeffrey C., Nazzari, Alexandra, Olia, Adam S., Shi, Wei, Sastry, Mallika, Stephens, Tyler, Stuckey, Jonathan, Teng, I-Ting, Wang, Pengfei, Wang, Shuishu, Zhang, Baoshan, Friesner, Richard A., Ho, David D., Mascola, John R., Shapiro, Lawrence, Kwong, Peter D.“…In the absence of ACE2, single-RBD-up conformations dominated at pH 5.5, resolving into a solitary all-down conformation at lower pH. …”
Publicado 2020
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1887por Liu, Kefang, Tan, Shuguang, Niu, Sheng, Wang, Jia, Wu, Lili, Sun, Huan, Zhang, Yanfang, Pan, Xiaoqian, Qu, Xiao, Du, Pei, Meng, Yumin, Jia, Yunfei, Chen, Qian, Deng, Chuxia, Yan, Jinghua, Wang, Hong-Wei, Wang, Qihui, Qi, Jianxun, Gao, George Fu“…The structure of the SARS-CoV-2 RBD with the bACE2-Rm complex was determined, revealing a binding mode similar to that of hACE2. …”
Publicado 2021
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1888por Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Hartwell, Brittany L., Tostanoski, Lisa H., Biedermann, Andrew M., Crowell, Laura E., Kaur, Kawaljit, Kumru, Ozan, Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A., Rodrigues, Kristen A., Silva, Murillo, Johnston, Ryan S., Naranjo, Christopher A., Tracey, Mary Kate, Brady, Joseph R., Whittaker, Charles A., Yun, Dongsoo, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G., Love, Kerry R., Camp, Danielle L., Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B., Volkin, David B., Dubois, Patrice M., Collin, Nicolas, King, Neil P., Barouch, Dan H., Irvine, Darrell J., Love, J. Christopher“…Presentation of the engineered RBD on a designed virus-like particle (VLP) also reduced weight loss in hamsters upon viral challenge.…”
Publicado 2021
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1889por Hwang, William C., Lin, Yaqiong, Santelli, Eugenio, Sui, Jianhua, Jaroszewski, Lukasz, Stec, Boguslaw, Farzan, Michael, Marasco, Wayne A., Liddington, Robert C.“…Here we report the crystal structure of the S1 receptor binding domain (RBD) in complex with a neutralizing antibody, 80R, at 2.3 Å resolution, as well as the structure of the uncomplexed S1 RBD at 2.2 Å resolution. …”
Publicado 2006
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1890por Liu, Kefang, Pan, Xiaoqian, Li, Linjie, Yu, Feng, Zheng, Anqi, Du, Pei, Han, Pengcheng, Meng, Yumin, Zhang, Yanfang, Wu, Lili, Chen, Qian, Song, Chunli, Jia, Yunfei, Niu, Sheng, Lu, Dan, Qiao, Chengpeng, Chen, Zhihai, Ma, Dongli, Ma, Xiaopeng, Tan, Shuguang, Zhao, Xin, Qi, Jianxun, Gao, George F., Wang, Qihui“…Here we obtained the complex structure of the RaTG13 receptor binding domain (RBD) with human ACE2 (hACE2) and evaluated binding of RaTG13 RBD to 24 additional ACE2 orthologs. …”
Publicado 2021
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1891por Salvagno, Gian Luca, Henry, Brandon M., di Piazza, Giovanni, Pighi, Laura, De Nitto, Simone, Bragantini, Damiano, Gianfilippi, Gian Luca, Lippi, Giuseppe“…Background: This study monitored total anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) RBD (receptor-binding domain) antibodies levels in a large population of healthcare workers undergoing mRNA COVID-19 vaccination. …”
Publicado 2021
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1892por Becker, Matthias, Dulovic, Alex, Junker, Daniel, Ruetalo, Natalia, Kaiser, Philipp D., Pinilla, Yudi T., Heinzel, Constanze, Haering, Julia, Traenkle, Bjoern, Wagner, Teresa R., Layer, Mirjam, Mehrlaender, Martin, Mirakaj, Valbona, Held, Jana, Planatscher, Hannes, Schenke-Layland, Katja, Krause, Gérard, Strengert, Monika, Bakchoul, Tamam, Althaus, Karina, Fendel, Rolf, Kreidenweiss, Andrea, Koeppen, Michael, Rothbauer, Ulrich, Schindler, Michael, Schneiderhan-Marra, Nicole“…SARS-CoV-2 is evolving with mutations in the receptor binding domain (RBD) being of particular concern. It is important to know how much cross-protection is offered between strains following vaccination or infection. …”
Publicado 2021
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1893por Zhang, Yuzhao, He, Xibing, Zhai, Jingchen, Ji, Beihong, Man, Viet Hoang, Wang, Junmei“…The virus infects human using its spike glycoprotein mediated by a crucial area, receptor-binding domain (RBD), to bind to the human ACE2 (hACE2) receptor. …”
Publicado 2021
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1894por Wei, Liwen, Shang, Yuqi, Liu, Xi, Li, Xinghua, Chen, Gongqi, Liang, Siping, Zou, Zhengyu, Ding, Tao, Hong, Zhongsi, Wu, Minhao, Xia, Jinyu“…The IgG and IgM antibodies against receptor binding domain (RBD) and spike protein subunit 1 (S1) of SAS-COV-2 were detected by ELISA. …”
Publicado 2021
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1895por Amraei, Razie, Yin, Wenqing, Napoleon, Marc A., Suder, Ellen L., Berrigan, Jacob, Zhao, Qing, Olejnik, Judith, Chandler, Kevin Brown, Xia, Chaoshuang, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Schmidt, Aaron G., Gummuluru, Suryaram, Mühlberger, Elke, Chitalia, Vipul, Costello, Catherine E., Rahimi, Nader“…Multiple biochemical assays using a purified recombinant SARS-CoV-2 spike receptor-binding domain (S-RBD) or S1 encompassing both N termal domain and RBD and ectopically expressed CD209L and CD209 revealed that CD209L and CD209 interact with S-RBD. …”
Publicado 2021
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1896por Liu, Bo, Yin, Ying, Liu, Yuxiao, Wang, Tiantian, Sun, Peng, Ou, Yangqin, Gong, Xin, Hou, Xuchen, Zhang, Jun, Ren, Hongguang, Luo, Shiqiang, Ke, Qian, Yao, Yongming, Xu, Junjie, Wu, Jun“…SARS-CoV-2 infects the host by binding to the cellular receptor angiotensin converting enzyme 2 (ACE2) via the receptor-binding domain (RBD) of the surface spike (S) glycoprotein. In this study, a candidate vaccine based on a RBD recombinant subunit was prepared by means of a novel glycoengineered yeast Pichia pastoris expression system with characteristics of glycosylation modification similar to those of mammalian cells. …”
Publicado 2022
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1897“…Over one year ago, we foresaw that mutations on RBD residues, 452 and 501, would “both have high chances to mutate into significantly more infectious COVID-19 strains”. …”
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1898por Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Hartwell, Brittany L., Tostanoski, Lisa H., Biedermann, Andrew M., Crowell, Laura E., Kaur, Kawaljit, Kumru, Ozan S., Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A., Rodrigues, Kristen A., Silva, Murillo, Johnston, Ryan S., Naranjo, Christopher A., Tracey, Mary Kate, Brady, Joseph R., Whittaker, Charles A., Yun, Dongsoo, Brunette, Natalie, Wang, Jing Yang, Walkey, Carl, Fiala, Brooke, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G., Love, Kerry R., Camp, Danielle L., Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B., Volkin, David B., Dubois, Patrice M., Collin, Nicolas, King, Neil P., Barouch, Dan H., Irvine, Darrell J., Love, J. Christopher“…Presentation of the engineered RBD on a designed virus-like particle (VLP) also reduced weight loss in hamsters upon viral challenge.…”
Publicado 2021
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1899“…The latter is notable for a loss of binding affinity of DPP4 with MERS-CoV S1 RBD that might affect negatively on cellular entry of the virus. …”
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1900por Dong, Jinhui, Zost, Seth J., Greaney, Allison J., Starr, Tyler N., Dingens, Adam S., Chen, Elaine C., Chen, Rita E., Case, James Brett, Sutton, Rachel E., Gilchuk, Pavlo, Rodriguez, Jessica, Armstrong, Erica, Gainza, Christopher, Nargi, Rachel S., Binshtein, Elad, Xie, Xuping, Zhang, Xianwen, Shi, Pei-Yong, Logue, James, Weston, Stuart, McGrath, Marisa E., Frieman, Matthew B., Brady, Tyler, Tuffy, Kevin, Bright, Helen, Loo, Yueh-Ming, McTamney, Patrick M., Esser, Mark T., Carnahan, Robert H., Diamond, Michael S., Bloom, Jesse D., Crowe, James E.“…Both AZD8895 and AZD1061 have strong neutralizing activity against SARS-CoV-2 and variants of concern with antigenic substitutions in the RBD. We conclude that germline-encoded antibody features enable recognition of the SARS-CoV-2 spike RBD and demonstrate the utility of the cocktail AZD7442 in neutralizing emerging variant viruses.…”
Publicado 2021
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