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1“…This article reviews recent research from longitudinal research studies in isolated RBD (iRBD) aiming to describe the most promising progression biomarkers of iRBD and to delineate the current knowledge on the level of prediction of future outcome in iRBD patients at diagnosis. …”
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2por Sun, Shiyu, Cai, Yueqi, Song, Tian-Zhang, Pu, Yang, Cheng, Lin, Xu, Hairong, Sun, Jing, Meng, Chaoyang, Lin, Yifan, Huang, Haibin, Zhao, Fang, Zhang, Silin, Gao, Yu, Han, Jian-Bao, Feng, Xiao-Li, Yu, Dan-Dan, Zhu, Yalan, Gao, Pu, Tang, Haidong, Zhao, Jincun, Zhang, Zheng, Yang, Jiaming, Hu, Zhenxiang, Fu, Yang-Xin, Zheng, Yong-Tang, Peng, Hua“…I-R-F efficiently directs immunity against RBD to DLNs. A low dose of I-R-F induces not only high titers of long-lasting neutralizing antibodies (NAbs) but also more comprehensive T cell responses than RBD. …”
Publicado 2021
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3por Gong, Si-Yi, Shen, Yun, Gu, Han-Ying, Zhuang, Sheng, Fu, Xiang, Wang, Qiao-Jun, Mao, Cheng-Jie, Hu, Hua, Dai, Yong-Ping, Liu, Chun-Feng“…PURPOSE: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is the prodromal marker of α-synuclein degeneration with markedly high predictive value. …”
Publicado 2022
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4por Lanza, Giuseppe, Cosentino, Filomena Irene Ilaria, Lanuzza, Bartolo, Tripodi, Mariangela, Aricò, Debora, Figorilli, Michela, Puligheddu, Monica, Fisicaro, Francesco, Bella, Rita, Ferri, Raffaele, Pennisi, Manuela“…Background: a reduced intracortical facilitation (ICF), a transcranial magnetic stimulation (TMS) measure largely mediated by glutamatergic neurotransmission, was observed in subjects affected by isolated REM sleep behavior disorder (iRBD). However, direct comparison between iRBD and Parkinson’s disease (PD) with RBD is currently lacking. …”
Publicado 2022
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5por Gerez, Guillaume, Martinez, Jerome, Steinbrugger, Christophe, Bouanich, Sandra, Dimino, Johanna, Piegay, Corine, Combe, Maxime, Berthier, Franck, Daniel, Soizic“…SARS-CoV-2 receptor-binding domain (RBD) is a major target for the development of diagnostics, vaccines and therapeutics directed against COVID-19. …”
Publicado 2022
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6“…PKR contains two tandem double-stranded RNA binding domains at the N-terminus, dsRBD1 and dsRBD2, and a C-terminal kinase domain. …”
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7por Sun, Shiyu, Cai, Yueqi, Song, Tian-Zhang, Pu, Yang, Cheng, Lin, Xu, Hairong, Sun, Jing, Meng, Chaoyang, Lin, Yifan, Huang, Haibin, Zhao, Fang, Zhang, Silin, Gao, Yu, Han, Jian-Bao, Feng, Xiao-Li, Yu, Dan-Dan, Zhu, Yalan, Gao, Pu, Tang, Haidong, Zhao, Jincun, Zhang, Zheng, Yang, Jiaming, Hu, Zhenxiang, Fu, Yang-Xin, Zheng, Yong-Tang, Peng, HuaEnlace del recurso
Publicado 2021
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8por Tai, Wanbo, He, Lei, Zhang, Xiujuan, Pu, Jing, Voronin, Denis, Jiang, Shibo, Zhou, Yusen, Du, Lanying“…SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and, hence, attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells, thus inhibiting their infection to host cells. …”
Publicado 2020
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9“…We show that the experimentally measured changes in the ACE2-RBD dissociation constants for a variety of engineered ACE2 glycoforms are in reasonable agreement with our theory, thus supporting our hypothesis. …”
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10por Barone, Daniel A., Sarva, Harini, Hellmers, Natalie, Wang, Fei, Wu, Zhenxing, Krieger, Ana C., Henchcliffe, Claire“…INTRODUCTION: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is linked to Parkinson’s disease and other alpha-synucleinopathies, but various subsets of iRBD may not carry equal risk (i.e., those with depression are at higher risk than those without). …”
Publicado 2023
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11“…Objective: Hyposmia may occur simultaneously with REM sleep behavior disorder (RBD) as a specific phenotype in Parkinson's Diseases (PD), of which the disease progression is fast. …”
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12por Greaney, Allison J., Loes, Andrea N., Gentles, Lauren E., Crawford, Katharine H.D., Starr, Tyler N., Malone, Keara D., Chu, Helen Y., Bloom, Jesse D.“…The neutralizing activity of vaccine-elicited antibodies is even more focused on the spike receptor-binding domain (RBD) than for infection-elicited antibodies. However, within the RBD, binding of vaccine-elicited antibodies is more broadly distributed across epitopes than for infection-elicited antibodies. …”
Publicado 2021
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13por Gomes, Larissa R., Durans, Andressa M., Napoleão-Pêgo, Paloma, Waterman, Jessica A., Freitas, Mariana S., De Sá, Nathalia B. R., Pereira, Lilian V., Furtado, Jéssica S., Aquino, Romário G., Machado, Mario C. R., Fintelman-Rodrigues, Natalia, Souza, Thiago M. L., Morel, Carlos M., Provance, David W., De-Simone, Salvatore G.“…After their similarity to other pathogen sequences was analyzed, 11 epitopes outside of the receptor-binding domain (RBD) of the spike protein that showed high reactivity and uniqueness to the virus. …”
Publicado 2021
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14“…Constant evolution of SARS-CoV-2 generates new mutations across its genome including the coding region for the RBD in the spike protein. In addition to the well-known single mutation in the RBD, the recent new mutation strains with an RBD “double mutation” are causing new outbreaks globally, as represented by the delta strain containing RBD L452R/T478K. …”
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15por Junker, Daniel, Dulovic, Alex, Becker, Matthias, Wagner, Teresa R., Kaiser, Philipp D., Traenkle, Bjoern, Kienzle, Katharina, Bunk, Stefanie, Struemper, Carlotta, Haeberle, Helene, Schmauder, Kristina, Ruetalo, Natalia, Malek, Nisar, Althaus, Karina, Koeppen, Michael, Rothbauer, Ulrich, Walz, Juliane S., Schindler, Michael, Bitzer, Michael, Göpel, Siri, Schneiderhan-Marra, Nicole“…Neutralizing antibodies (Nabs) targeting the receptor binding domain (RBD) of SARS-CoV-2 are promising correlates of protective immunity and have been successfully used for prevention and therapy. …”
Publicado 2022
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16por Kenny, Grace, O’Reilly, Sophie R, Kelly, Neil Wrigley, Negi, Riya, Gaillard, Colette Marie, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, García-León, Alejandro, Tinago, Willard, Feeney, Eoin R, Cotter, Aoife, de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Cox, Rebecca J, O’Shea, Donal, Olesen, Ole, Landay, Alan, Hogan, Andrew, Lelièvre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A, Mallon, Patrick“…[Figure: see text] [Figure: see text] CONCLUSION: Host RBD titres closely correlate with NT50. An RBD threshold of < 456 BAU/ml accurately predicts a clinically relevant neutralising capacity against both WT and common VOC. …”
Publicado 2023
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17por Borgoyakova, Mariya B., Karpenko, Larisa I., Rudometov, Andrey P., Volosnikova, Ekaterina A., Merkuleva, Iuliia A., Starostina, Ekaterina V., Zadorozhny, Alexey M., Isaeva, Anastasiya A., Nesmeyanova, Valentina S., Shanshin, Daniil V., Baranov, Konstantin O., Volkova, Natalya V., Zaitsev, Boris N., Orlova, Lyubov A., Zaykovskaya, Anna V., Pyankov, Oleg V., Danilenko, Elena D., Bazhan, Sergei I., Shcherbakov, Dmitry N., Taranin, Alexander V., Ilyichev, Alexander A.“…The receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 was conjugated to polyglucin:spermidine and mixed with DNA vaccine (pVAXrbd), which led to the formation of particles of combined coronavirus vaccine (CCV-RBD) that contain the DNA vaccine inside and RBD protein on the surface. …”
Publicado 2022
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18“…It is known that the receptor-binding structural domain (SARS-CoV-2 RBD) on the spike protein of the novel coronavirus directly mediates its interaction with the host receptor angiotensin-converting enzyme 2 (ACE2), and thus blocking SARS-CoV-2 RBD–ACE2 interaction is capable of inhibiting SARS-CoV-2 infection. …”
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