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Mostrando 481 - 500 Resultados de 292,959 Para Buscar '"Receptor"', tiempo de consulta: 1.29s Limitar resultados
  1. 481
    “…Although bromocriptine is the preferred first line treatment for prolactinoma, resistance frequently occurs, posing a prominent clinical challenge. Both the prolactin receptor (PRLR) and estrogen receptor α (ERα) serve critical roles in the development and progression of prolactinomas, and whether this interaction between PRLR and ERα contributes to bromocriptine resistance remains to be clarified. …”
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    Estrogen receptor α/prolactin receptor bilateral crosstalk promotes bromocriptine resistance in prolactinomas
  2. 482
    “…Protease-activated receptor-2 (PAR2) has been implicated in multiple pathophysiologies but drug discovery is challenging due to low small molecule tractability and a complex activation mechanism. …”
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    Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition
  3. 483
    “…Using a statistical mechanics model and Monte Carlo simulations, we explore how the adhesion of cell membranes affects the stability and coalescence of clusters enriched in receptor proteins. Our results show that intercellular receptor–ligand binding and membrane shape fluctuations can lead to receptor aggregation within the adhering membranes even if large-scale clusters are thermodynamically unstable in nonadhering membranes.…”
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    Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
  4. 484
    “…The current therapeutic modalities yielding encouraging results in clinical trials include the blockade of immune checkpoint receptors to overcome the immune-evasion mechanism used by tumors and the incorporation of tumor-directed chimeric antigen receptors to enhance NK cell antitumor specificity and activity. …”
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    Harnessing NK cells for cancer immunotherapy: immune checkpoint receptors and chimeric antigen receptors
  5. 485
    “…Thus, therapeutics stimulating glucagon receptor (GCGR) signaling are promising for obesity treatment; however, the underlying mechanism(s) have yet to be fully elucidated. …”
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    Glucagon receptor signaling regulates weight loss via central KLB receptor complexes
  6. 486
    “…T cells play an important role in antigen recognition by expressing a diverse repertoire of antigen-specific receptors, which bind epitopes to mount targeted immune responses. …”
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    TCRMatch: Predicting T-Cell Receptor Specificity Based on Sequence Similarity to Previously Characterized Receptors
  7. 487
    “…This evidence has led to the development of small molecules antagonist molecules of the CGRP receptor (“gepants”) and of a new class of medications called “Ditans”. …”
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    CGRP Receptor Antagonists and 5-HT1F Receptor Agonist in the Treatment of Migraine
  8. 488
    Materias: “…Steroid Hormones and Receptors…”
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    One Hormone for Two Receptors: Exploring Glucocorticoid Actions Mediated by the Glucocorticoid and Mineralocorticoid Receptors
  9. 489
    “…BACKGROUND: Oestrogen receptor (ER) status provides invaluable prognostic and therapeutic information in breast cancer (BC). …”
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    The impact of progesterone receptor negativity on oncological outcomes in oestrogen-receptor-positive breast cancer
  10. 490
    “…Confocal and STORM microscopy reveal that strongly agonistic reagents induce clusters characterized by small area and high receptor density. Using antibody pairs differing only in isotype we show that hIgG2 confers significantly more receptor clustering than hIgG1 across all three receptors, explaining its greater agonistic activity, with receptor clustering shielding the receptor-agonist complex from further molecular access. …”
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    TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
  11. 491
    “…Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis dysregulation observed in stress-related psychiatric disorders. …”
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    Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5
  12. 492
    “…BACKGROUND/AIMS: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a major regulator of Wnt signaling, which is involved in fibroblast dysfunction. …”
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    Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis
  13. 493
    “…We focused on identifying the roles of the progesterone receptor (PR) independent of estrogen receptor (ER) status. …”
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    Hormone Receptor Subtype in Ductal Carcinoma in Situ: Prognostic and Predictive Roles of the Progesterone Receptor
  14. 494
    “…Here, we describe a novel method for therapy of hyperinsulinemic hyperglycemia, highly selectively killing β-cells by receptor-targeted photodynamic therapy (rtPDT) with exendin-4-IRDye700DX, targeting the glucagon-like peptide 1 receptor (GLP-1R). …”
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    Receptor-Targeted Photodynamic Therapy of Glucagon-Like Peptide 1 Receptor–Positive Lesions
  15. 495
    “…Adoptive transfer of T-cell-receptor (TCR)-transduced T cells has shown promising results for cancer treatment, but has also produced severe immunotoxicities caused by on-target as well as off-target TCR recognition. …”
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    T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation
  16. 496
    “…The family of trace amine-associated receptors (TAARs) is distantly related to G protein-coupled biogenic aminergic receptors. …”
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    Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors
  17. 497
    “…In this study, we identified an ortholog encoding the odorant receptor co-receptor (Orco) in the Formosan subterranean termite, Coptotermes formosanus, and examined its expression variation across developmental stages and in response to social conditions. …”
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    Molecular characterization and expression variation of the odorant receptor co-receptor in the Formosan subterranean termite
  18. 498
    “…Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. …”
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    Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
  19. 499
    por Tezuka, Yuta, Ito, Sadayoshi
    Publicado 2022
    “…RECENT FINDINGS: Based on the unique structures, the nonsteroidal MRBs have higher selectivity for mineralocorticoid receptors (MRs) and show no agonist activity for major steroid hormone receptors in contrast to steroidal MRBs. …”
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    The Time to Reconsider Mineralocorticoid Receptor Blocking Strategy: Arrival of Nonsteroidal Mineralocorticoid Receptor Blockers
  20. 500
    “…The NMDA receptor (NMDAR) subunit GluN1 is critical for receptor function and plays a pivotal role in synaptic plasticity. …”
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    Regulation of NMDA Receptor Signaling at Single Synapses by Human Anti-NMDA Receptor Antibodies
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