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641por Cronstein, Bruce N.“…Recent studies have demonstrated that application of topical adenosine A(2A) receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A(2A) adenosine receptor agonists in the therapy of diabetic foot ulcers. …”
Publicado 2004
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642“…Receptor-mediated gene delivery capitalises on the presence of specific cell surface molecules for DNA uptake into cells and represents a particularly appealing approach for targeting vector DNA to specific cell types in vivo and in vitro. …”
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643“…However, whether KA activates KA receptors (KARs) as an agonist to mediate the induction of acute seizures and/or the chronic phase of epilepsy, or whether epileptogenic effects of the neurotoxin are indirect and/or mediated by other types of receptors, has yet to be satisfactorily elucidated. …”
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644“…Taste receptors were named for their originally-identified expression on the tongue and role in the sensation of taste (gustation). …”
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645por Gardiner, Elizabeth E.“…Shedding is critically important for normal cell function in the vasculature. Levels of platelet receptors GPIb‐IX‐V and GPVI are regulated by metalloproteolytic shedding. …”
Publicado 2018
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646por Sexton, Patrick M.“…Our understanding of G protein-coupled receptor function has recently expanded to encompass novel protein interactions that underlie both cell surface receptor expression and the exhibited phenotype. …”
Publicado 2001
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647“…The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, most notably white blood cells (leukocytes). …”
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648“…Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. …”
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649por Giovannelli, Pia, Di Donato, Marzia, Galasso, Giovanni, Di Zazzo, Erika, Bilancio, Antonio, Migliaccio, Antimo“…Although AR expression is often associated with a favorable prognosis in EREstradiol Receptorα-positive (ERα +) BC, many findings suggest that, in some instances, high levels of AR can contribute to the therapy-resistance. …”
Publicado 2018
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650por Cha, Dae RyongEnlace del recurso
Publicado 2018
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652“…Glucocorticoids convey their signals through an intracellular glucocorticoid receptor (GR), which is a transcriptional regulator. …”
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653“…The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. …”
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654por Vella, Veronica, Milluzzo, Agostino, Scalisi, Nunzio Massimo, Vigneri, Paolo, Sciacca, Laura“…The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. …”
Publicado 2018
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655“…Autoantibodies (Ab) against the thyroid-stimulating hormone receptor (TSHR) are frequently found in autoimmune thyroid disease (AITD). …”
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656“…A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.…”
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658“…The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, called α and β, to recognize pathogens. …”
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659“…Attachment of viruses to cell-surface receptors is the initial step in infection. Many mammalian viruses have evolved to recognize receptors that are glycans on cell-surface glycoproteins or glycolipids. …”
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660“…In this mini-review, we surveyed the current knowledge about semaphorins and their receptors in leukemias, lymphomas, and multiple myeloma. …”
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