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Mostrando 901 - 920 Resultados de 292,959 Para Buscar '"Receptor"', tiempo de consulta: 1.16s Limitar resultados
  1. 901
    “…BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year survival rate of 6% following a diagnosis, and novel therapeutic modalities are needed. Protease-activated receptor 1 (PAR1) is abundantly overexpressed by both tumor cells and multiple stroma cell subsets in the tumor microenvironment (TME), thereby offering a suitable immunotherapy target. …”
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    Effect of chimeric antigen receptor T cells against protease-activated receptor 1 for treating pancreatic cancer
  2. 902
    “…BACKGROUND: The extent to which the risk of estrogen receptor (ER)–specific breast cancer is associated with ER status of breast cancer and other cancers among first-degree relatives is unclear. …”
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    Risk of estrogen receptor–specific breast cancer by family history of estrogen receptor subtypes and other cancers
  3. 903
    “…Bradykinin (BK) reduces fibrosis in renal and cardiac damage models through the B2 receptor. The B1 receptor expression is induced by damage, and blocking of the kallikrein-kinin system seems to affect the progression of muscular dystrophy. …”
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    Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors
  4. 904
    “…METHODS: In this study, we addressed the impact of the receptor tyrosine kinase Axl binding to its ligand Gas6 in acquiring refractoriness to TKIs. …”
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    Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma
  5. 905
    “…Estrogen receptors (ERs) play a multitude of roles in brain function and are implicated in various brain disorders. …”
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    Peering into the Brain’s Estrogen Receptors: PET Tracers for Visualization of Nuclear and Extranuclear Estrogen Receptors in Brain Disorders
  6. 906
    “…BACKGROUND: The renin‐angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G‐protein–coupled receptors, the angiotensin type‐1 and type‐2 receptors, in almost every organ. …”
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    Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors
  7. 907
    “…This comprehensive review thoroughly explores the intricate involvement of insulin receptor (IR) isoforms and insulin-like growth factor receptors (IGFRs) in the context of the insulin and insulin-like growth factor (IGF) signaling (IIS) pathway. …”
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    Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance
  8. 908
    “…BACKGROUND: Steroid receptor-associated and regulated protein (SRARP) suppresses tumor progression and modulates steroid receptor signaling by interacting with estrogen receptors and androgen receptors in breast cancer. …”
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    Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer
  9. 909
    “…BACKGROUND: Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility, and stimulation of endocrine and exocrine gland secretion. …”
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    Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor
  10. 910
    “…RSNOs are capable of very targeted regulation, as they potentiate the signaling of some receptors (exemplified by the M2/M4 muscarinic cholinergic receptors), inhibit others (P2Y(12 )purinergic, LPA(1)lysophosphatidic acid, and cannabinoid CB(1 )receptors), but may only marginally affect signaling of others, such as adenosine A(1), μ-opioid, and opiate related receptors. …”
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    S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner
  11. 911
    “…Estrogen receptors are members of the nuclear receptor steroid family that exhibit specific structural features, ligand-binding domain sequence identity and dimeric interactions, that single them out. …”
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    Estrogen receptor transcription and transactivation: Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors
  12. 912
    “…BACKGROUND: Mammalian receptors that couple to effectors via heterotrimeric G proteins (e.g., beta (2)-adrenergic receptors) and receptors with intrinsic tyrosine kinase activity (e.g., insulin and IGF-I receptors) constitute the proximal points of two dominant cell signaling pathways. …”
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    Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking
  13. 913
    “…They represent an important group of physiologically active signalling molecules that bind intracellular receptor proteins and regulate genes involved in developmental, reproductive and metabolic processes. …”
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    Natural disordered sequences in the amino terminal domain of nuclear receptors: lessons from the androgen and glucocorticoid receptors
  14. 914
    por Cunha, Rodrigo A.
    Publicado 2005
    “…Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A(1) receptors (A(1)Rs) and the less abundant, but widespread, facilitatory A(2A)Rs. …”
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    Neuroprotection by adenosine in the brain: From A(1) receptor activation to A(2A) receptor blockade
  15. 915
    “…We report that isoforms of endothelin-converting enzyme-1 (ECE-1a–d) are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors. Calcitonin gene-related peptide (CGRP) co-internalizes with calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), β-arrestin2, and ECE-1 to early endosomes, where ECE-1 degrades CGRP. …”
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    Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and β-arrestins
  16. 916
    Publicado 1984
    “…We have used biochemical and morphological techniques to demonstrate that hepatocytes in the perfused liver bind, internalize, and degrade substantial amounts of murine epidermal growth factor (EGF) via a receptor-mediated process. Before ligand exposure, about 300,000 high- affinity receptors were detectable per cell, displayed no latency, and co-distributed with conventional plasma membrane markers. …”
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    Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics
  17. 917
    Publicado 1986
    “…The structure and processing of low density lipoprotein (LDL) receptors in wild-type and LDL receptor-deficient mutant Chinese hamster ovary cells was examined using polyclonal anti-receptor antibodies. …”
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    Unusual forms of low density lipoprotein receptors in hamster cell mutants with defects in the receptor structural gene
  18. 918
    Publicado 1987
    “…Platelet aggregation requires the binding of fibrinogen to its receptor, a heterodimer consisting of the plasma-membrane glycoproteins (GP) IIb and IIIa. …”
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    The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering
  19. 919
    Publicado 1987
    “…In this report we examine the relationship between this carbohydrate-binding receptor and the putative homing receptor identified by the MEL-14 antibody. …”
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    Receptors involved in lymphocyte homing: relationship between a carbohydrate-binding receptor and the MEL-14 antigen
  20. 920
    “…Immunoglobulin (Ig)α and Igβ initiate B cell receptor (BCR) signaling through immune receptor tyrosine activation motifs (ITAMs) that are targets of SH2 domain–containing kinases. …”
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    Igβ tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization
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