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  1. 961
    “…G(q)-coupled plasma membrane receptors activate phospholipase C (PLC), which hydrolyzes membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) into the second messengers inositol 1,4,5-trisphosphate (IP(3)) and diacylglycerol (DAG). …”
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    Quantitative properties and receptor reserve of the IP(3) and calcium branch of G(q)-coupled receptor signaling
  2. 962
    “…INTRODUCTION: We investigated the status of estrogen receptor alpha (ERα), progesterone receptor (PR), and epidermal growth factor receptor 2 (HER2) in primary tumor and in the corresponding brain metastases in a consecutive series of breast cancer patients. …”
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    Conversion of epidermal growth factor receptor 2 and hormone receptor expression in breast cancer metastases to the brain
  3. 963
    por Xie, M, Zhang, H, Xu, Y, Liu, T, Chen, S, Wang, J, Zhang, T
    Publicado 2013
    “…As shown by immunohistochemistry, 83.3% (30/36) of the head and neck squamous carcinomas expressed the folate receptor versus none in the control group (0/24). Only the HNE-1 and Hep-2 cell lines expressed the folate receptor, and the other five cell lines did not. …”
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    Expression of folate receptors in nasopharyngeal and laryngeal carcinoma and folate receptor-mediated endocytosis by molecular targeted nanomedicine
  4. 964
    “…BACKGROUND: Directly comparing gene expression profiles of estrogen receptor-positive (ER+) and estrogen receptor-negative (ER−) breast cancers cannot determine whether differentially expressed genes between these two subtypes result from dysregulated expression in ER+ cancer or ER− cancer versus normal controls, and thus would miss critical information for elucidating the transcriptomic difference between the two subtypes. …”
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    Genes Dysregulated to Different Extent or Oppositely in Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancers
  5. 965
    “…The spike glycoprotein (S) of recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) targets the cellular receptor, dipeptidyl peptidase 4 (DPP4). Sequence comparison and modeling analysis have revealed a putative receptor-binding domain (RBD) on the viral spike, which mediates this interaction. …”
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    Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4
  6. 966
    “…These features of an ideal compound are not only dependent upon pharmacokinetics, receptor binding kinetics, potency and pharmacodynamic activity, but also upon a compound’s mechanism of action. …”
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    The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
  7. 967
    “…In the present paper, the model is extended by accounting explicitly for the kinetics of the interaction between the co-receptor and the MHCI molecule. We show that T-cells can modulate the level of degeneracy by varying the density of co-receptors on the cell surface. …”
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    Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy
  8. 968
    “…BACKGROUND: G protein-coupled receptors (GPCRs) are the targets of a large number of drugs currently in therapeutic use. …”
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    HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity
  9. 969
    “…G-protein-coupled receptors (GPCRs) are known to activate both G protein- and β-arrestin-dependent signalling cascades. …”
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    ERK5 Activation by Gq-Coupled Muscarinic Receptors Is Independent of Receptor Internalization and β-Arrestin Recruitment
  10. 970
    por Somvanshi, Rishi K., Kumar, Ujendra
    Publicado 2014
    “…Cotransfected cells display inhibition of cAMP/PKA and co-activation of SSTR4 and δOR oppose receptor trafficking induced by individual receptor activation. …”
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    δ-Opioid Receptor and Somatostatin Receptor-4 Heterodimerization: Possible Implications in Modulation of Pain Associated Signaling
  11. 971
    Publicado 2014
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    Correction: The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity
  12. 972
    “…Sortilin is a type I membrane glycoprotein belonging to the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors and is most abundantly expressed in the central nervous system. …”
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    Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex
  13. 973
    “…We have recently identified protein phosphatase 1β (PP1β) as G protein-coupled receptor (GPCR) phosphatase for the sst(2) somatostatin receptor using siRNA knockdown screening. …”
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    Carboxyl-Terminal Receptor Domains Control the Differential Dephosphorylation of Somatostatin Receptors by Protein Phosphatase 1 Isoforms
  14. 974
    “…G Protein Coupled Receptors (GPCRs) are the largest family of receptors whose ligands constitute nearly a third of prescription drugs in the market. …”
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    Recent Progress in Understanding Subtype Specific Regulation of NMDA Receptors by G Protein Coupled Receptors (GPCRs)
  15. 975
    “…INTRODUCTION: The two isoforms of estrogen receptor (ER) alpha and beta play opposite roles in regulating proliferation and differentiation of breast cancers, with ER-alpha mediating mitogenic effects and ER-beta acting as a tumor suppressor. …”
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    Estrogen receptor beta as a novel target of androgen receptor action in breast cancer cell lines
  16. 976
    “…[Image: see text] Riboflavin receptors are overexpressed in malignant cells from certain human breast and prostate cancers, and they constitute a group of potential surface markers important for cancer targeted delivery of therapeutic agents and imaging molecules. …”
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    Atomic Force Microscopy Probing of Receptor–Nanoparticle Interactions for Riboflavin Receptor Targeted Gold–Dendrimer Nanocomposites
  17. 977
    “…While phagocytosis proceeds, bystander healthy cells protect themselves by sending a “do not eat me” message to phagocytes as CD47 on their surface ligates immune inhibitory receptor SIRPα on the surface of phagocytes and SIRPα then produces the signaling which inhibits phagocytosis. …”
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    Phagocytic receptors activate and immune inhibitory receptor SIRPα inhibits phagocytosis through paxillin and cofilin
  18. 978
    “…The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). …”
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    Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits
  19. 979
    “…G protein-coupled receptors (GPCRs) represent one of the largest families of cell surface receptors, and are the target of at least one-third of the current therapeutic drugs on the market. …”
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    A Rapid and Efficient Immunoenzymatic Assay to Detect Receptor Protein Interactions: G Protein-Coupled Receptors
  20. 980
    “…Upregulation of constitutively-active androgen receptor splice variants (AR-Vs) has been implicated in AR-driven tumor progression in castration-resistant prostate cancer. …”
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    Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy
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