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1081por Cortés-Montero, Elsa, Rodríguez-Muñoz, María, Ruiz-Cantero, M. Carmen, Cobos, Enrique J., Sánchez-Blázquez, Pilar, Garzón-Niño, Javier“…Transient receptor potential ankyrin member 1 (TRPA1) belongs to the family of thermo TRP cation channels that detect harmful temperatures, acids and numerous chemical pollutants. …”
Publicado 2020
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1082Toll‐like receptors (TLRs): An old family of immune receptors with a new face in cancer pathogenesispor Mokhtari, Yazdan, Pourbagheri‐Sigaroodi, Atieh, Zafari, Parisa, Bagheri, Nader, Ghaffari, Seyed H., Bashash, Davood“…But this is not everything about these receptors as they could orchestrate several downstream signalling pathways leading to the formation or suppression of cancer cells. …”
Publicado 2020
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1083por Tanahashi, Yasuyuki, Komori, Seiichi, Matsuyama, Hayato, Kitazawa, Takio, Unno, Toshihiro“…Parasympathetic signalling via muscarinic acetylcholine receptors (mAChRs) regulates gastrointestinal smooth muscle function. …”
Publicado 2021
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1084por Arroyo, Eliott, Laudato, Joseph A., Gibson, Brandon M., Dulaney, Cody S., Vaughan, Jeremiah A., Followay, Brittany N., Glickman, Ellen L., Jajtner, Adam R.“…The purpose of this study was to evaluate the effects of aerobic exercise in the heat on circulating concentrations of tumor necrosis factor (TNF)-α, soluble TNF receptors (STNFR1&2), and surface expression of TNFR1&2 on monocyte subpopulations. …”
Publicado 2020
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1085por Kaufman, Nichole E. M., Dhingra, Simran, Jois, Seetharama D., Vicente, Maria da Graça H.“…Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins that are frequently overexpressed in many cancers. …”
Publicado 2021
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1086por Imbastari, Francesca, Dahlmann, Mathias, Sporbert, Anje, Mattioli, Camilla Ciolli, Mari, Tommaso, Scholz, Florian, Timm, Lena, Twamley, Shailey, Migotti, Rebekka, Walther, Wolfgang, Dittmar, Gunnar, Rehm, Armin, Stein, Ulrike“…We unveiled a MACC1-dependent routing of internalized transferrin receptor towards recycling. Elevated MACC1 expression caused also the activation and internalization of EGFR, a higher rate of receptor recycling, as well as earlier and stronger receptor activation and downstream signaling. …”
Publicado 2021
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1087por Kulik, Marina, Bothe, Melissa, Kibar, Gözde, Fuchs, Alisa, Schöne, Stefanie, Prekovic, Stefan, Mayayo-Peralta, Isabel, Chung, Ho-Ryun, Zwart, Wilbert, Helsen, Christine, Claessens, Frank, Meijsing, Sebastiaan H“…The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet have nearly identical DNA binding specificities. …”
Publicado 2021
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1088por Valdés-Rives, Silvia Anahi, Arcos-Montoya, Denisse, de la Fuente-Granada, Marisol, Zamora-Sánchez, Carmen J., Arias-Romero, Luis Enrique, Villamar-Cruz, Olga, Camacho-Arroyo, Ignacio, Pérez-Tapia, Sonia M., González-Arenas, Aliesha“…A downstream target of PKC, involved in GBM progression, is the intracellular progesterone receptor (PR), which can be phosphorylated by this enzyme, increasing its transcriptional activity. …”
Publicado 2021
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1089por Shen, Chia-Hsing, Chou, Chih-Chang, Lai, Ting-Yu, Hsu, Jer-En, Lin, You-Sheng, Liu, Huai-Yu, Chen, Yan-Kai, Ho, I-Lin, Hsu, Pang-Hung, Chuang, Tsung-Hsien, Lee, Chih-Yuan, Hsu, Li-Chung“…Activation of the epidermal growth factor receptor (EGFR) is crucial for development, tissue homeostasis, and immunity. …”
Publicado 2021
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1090por Piltonen, Marjo, Krokhotin, Andrey, Parisien, Marc, Bérubé, Pierre, Djambazian, Haig, Sladek, Rob, Dokholyan, Nikolay V., Shabalina, Svetlana A., Diatchenko, Luda“…The opioid receptor (OPR) family comprises the mu-, delta-, and kappa-opioid, and nociceptin receptors that belong to the superfamily of 7-transmembrane spanning G protein-coupled receptors (GPCRs). …”
Publicado 2020
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1091“…We develop and analyze mathematical models for receptor-mediated transcytosis of monoclonal antibodies (MAb) targeting the transferrin receptor (TfR) or the insulin receptor (IR), which are expressed at the blood-brain barrier (BBB). …”
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1092por Juntikka, Tiina, Vaittinen, Samuli, Vahlberg, Tero, Jyrkkiö, Sirkku, Minn, Heikki“…BACKGROUND: Somatostatin receptors (SSTR) and chemokine receptor CXCR4 are expressed in lymphomas, while the abundance is known to be heterogeneous in different subtypes of lymphomas. …”
Publicado 2021
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1093por Mustafá, Emilio R., Cordisco González, Santiago, Damian, Marjorie, Cantel, Sonia, Denoyelle, Severine, Wagner, Renaud, Schiöth, Helgi B., Fehrentz, Jean-Alain, Banères, Jean-Louis, Perelló, Mario, Raingo, Jesica“…The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 receptor (D2R). …”
Publicado 2021
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1094por Budzinski, Julian, Maschauer, Simone, Kobayashi, Hiroyuki, Couvineau, Pierre, Vogt, Hannah, Gmeiner, Peter, Roggenhofer, Anna, Prante, Olaf, Bouvier, Michel, Weikert, Dorothee“…Taking advantage of previously described heterobivalent dopamine-neurotensin receptor ligands, we demonstrate specific interactions between dopamine D3 (D(3)R) and neurotensin receptor 1 (NTSR1), two receptors with expression in overlapping brain areas that are associated with neuropsychiatric diseases and addiction. …”
Publicado 2021
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1095por Nair, Jithin D., Braksator, Ellen, Yucel, Busra P., Fletcher-Jones, Alexandra, Seager, Richard, Mellor, Jack R., Bashir, Zafar I., Wilkinson, Kevin A., Henley, Jeremy M.“…Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) endocytosis and induces LTD of AMPARs (KAR-LTD(AMPAR)) in hippocampal neurons. …”
Publicado 2021
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1096por Mehboob, Riffat, Gilani, Syed Amir, Hassan, Amber, Sadaf, Tanvir, Imrana, Javaid, Shaista, Khalid, Sidra, Hasan, Sana, Waseem, Humaira, Alwazzan, Ahmad, Munoz, Miguel“…Expression and immunolocalization of Substance P (SP)/Neurokinin-1 Receptor (NK-1R) in breast carcinoma (BC) patients and its association with routine proliferative markers (ER, PR, HER2/neu, and Ki-67) were evaluated. …”
Publicado 2021
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1097por Borner, Tito, Geisler, Caroline E., Fortin, Samantha M., Cosgrove, Richard, Alsina-Fernandez, Jorge, Dogra, Mridula, Doebley, Sarah, Sanchez-Navarro, Marcos J., Leon, Rosa M., Gaisinsky, Jane, White, Arianna, Bamezai, Ankur, Ghidewon, Misgana Y., Grill, Harvey J., Crist, Richard C., Reiner, Benjamin C., Ai, Minrong, Samms, Ricardo J., De Jonghe, Bart C., Hayes, Matthew R.“…Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity and diabetes. …”
Publicado 2021
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1098por Hakhamaneshi, Mohammad Saeed, Abdolahi, Alina, Vahabzadeh, Zakaria, Abdi, Mohammad, Andalibi, Pedram“…TMAO can cause the endoplasmic reticulum (ER) stress that triggers activation of Toll-Like Receptors (TLRs). In macrophages, this process stimulates the production of proinflammatory cytokines. …”
Publicado 2021
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1099“…The key role in this process plays appropriate action of progesterone through the nuclear receptor isoforms. The action of the receptor is regulated by the attachment of receptor modulators called coregulators which include coactivators and corepressors. …”
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1100“…The subunit composition of these receptors determines their permeability to monovalent and/or divalent cations, but it is not entirely clear how this selectivity arises in native and recombinantly-expressed receptor populations. …”
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