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  1. 149761
    “…Remarkably, when we examined first-episode patients with antipsychotic exposure of less than 6 months, we found an extremely high correlation in the non-responsive group R(5)=0.95, P=0.01, compared to the responsive-group,R(20)=0.44, P<0.05, which reflected a large effect size of d=0.99. Chronically-ill resistant patients showed a significant correlation R(21)=0.48, P<0.05 and responsive trend-level correlation R(21)=0.41, P=0.07, but neither group differed from healthy controls. …”
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    O6.8. GLUTAMATERGIC DYSFUCTION AND TREATMENT RESPONSE IN MINIMALLY TREATED AND CHRONIC SCHIZOPHRENIA PATIENTS
  2. 149762
    “…However, examination of microRNAs in cerebrospinal fluid (CSF) might provide an in vivo biomarker, more accurately reflecting expression level changes in the brain. To date, there are no studies that have investigated miRNA expression in CSF in patients with schizophrenia using small RNA-seq. …”
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    F10. DIFFERENTIAL EXPRESSION OF MICRORNAS IN CEREBROSPINAL FLUID AND PLASMA SAMPLES IN SCHIZOPHRENIA
  3. 149763
    “…There was a general improvement in function between baseline and follow-up, reflected in the CGI-S score reduction from 5.17 (SD .619) to 3.70 (SD 1.09) and symptom reduction in PANSS positive: mean change - 6.68 (SD 5.00). …”
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    S57. TREATMENT SATISFACTION IN ACUTE PHASE PSYCHOSIS: COMPARISON BETWEEN ANTIPSYCHOTIC NAïVE AND PREVIOUSLY MEDICATED PATIENTS
  4. 149764
    “…In the SCZ group there was a significant correlation between the total SSPI score reflecting overall illness severity (□ = -.322, p < 0.05) and the mean GS. …”
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    T143. NOT A NUISANCE ANY MORE: GLOBAL FMRI SIGNAL AT REST, PROCESSING SPEED AND SYMPTOM SEVERITY IN SCHIZOPHRENIA
  5. 149765
    “…Despite the evidence of alterations in both dopamine and glutamate in schizophrenia, the degree to which these alterations are trait markers linked to genetic risk for psychosis or reflects state changes is not clear from previous studies. …”
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    S181. THE STATE OR TRAIT COMPONENT OF DOPAMINE AND GLUTAMATE DYSFUNCTION IN THE RISK FOR PSYCHOSIS: AN IN VIVO MULTIMODAL IMAGING STUDY OF INDIVIDUALS WITH 22Q11.2 DELETION
  6. 149766
    “…The different direction of the genetic effects among patients and controls reflects the complex relationship between genetic factors and cognitive performance variability. …”
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    T80. CALCIUM AND POTASSIUM VOLTAGE-GATED CHANNELS GENES ASSOCIATION ANALYSIS: EVIDENCE ON THEIR ROLE IN COGNITIVE PERFORMANCE OF SCHIZOPHRENIA PATIENTS AND HEALTHY SUBJECTS
  7. 149767
    “…Pro-social time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance were assessed with the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT). A serial of tests reflecting retrospective memory and executive functions were also administrated. …”
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    S72. PRO-SOCIAL PROSPECTIVE MEMORY PERFORMANCE IS ASSOCIATED WITH PLASMA OXYTOCIN LEVEL IN SEXUALLY DIMORPHIC WAY IN FIRST-DEGREE RELATIVES OF SCHIZOPHRENIA
  8. 149768
    “…Many patients are considered inoperable or at high surgical risk for surgical aortic valve replacement (SAVR), reflecting their age, comorbidities and frailty. The clinical effectiveness and safety of TAVI have not been reviewed systematically for these high levels of surgical risk. …”
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    Transcatheter aortic valve implantation for aortic stenosis in high surgical risk patients: A systematic review and meta-analysis
  9. 149769
    “…Leprosy serology reflects the bacillary load of patients and multidrug therapy (MDT) reduces Mycobacterium leprae-specific antibody titers of multibacillary (MB) patients. …”
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    Mycobacterium leprae-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT
  10. 149770
    “…PURPOSE: We present a novel gamma‐ray‐detector design based on total internal reflection (TIR) of scintillation photons within a crystal that addresses many limitations of traditional PET detectors. …”
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    An edge‐readout, multilayer detector for positron emission tomography
  11. 149771
    “…CONCLUSIONS: This study underlines the importance of employing integrative approaches of diseases prevention and control in which existing NCD programs in underserved communities (ie, rural and refugee camps settings) are coupled with innovative, low-cost approaches such as mHealth to provide an effective and amplified effect of traditional NCD-targeted care that can be reflected by improved NCD-related health indicators among the population. …”
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    Using Mobile Health to Enhance Outcomes of Noncommunicable Diseases Care in Rural Settings and Refugee Camps: Randomized Controlled Trial
  12. 149772
    “…Discordant coding resulted from several reasons but mostly reflected a difference in purpose. The MTS:PTC coding principles aim to capture the most specific reported information about an ADE, whereas PatientsLikeMe may code patient-reported symptoms and ADEs to more general MedDRA terms to support patient engagement among a larger group of patients. …”
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    Validating a Framework for Coding Patient-Reported Health Information to the Medical Dictionary for Regulatory Activities Terminology: An Evaluative Study
  13. 149773
    “…Discussion: Through identification of elements that overlap and diverge between existing models and frameworks, this review will provide a starting point for the critical reflection on our collective understanding of what patient engagement in health services research is and/or could be. …”
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    Models and frameworks of patient engagement in health services research: a scoping review protocol
  14. 149774
    “…These data provide evidence of greater systemic oxidative stress in severe asthma smokers as reflected by a significant changes of NOX2 mRNA expression in the airways, together with elevated urinary 8-iso-PGF(2α) in the smokers/ex-smokers group. …”
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    Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort
  15. 149775
    “…The SP method has limitations: it cannot account for patient mix or care-management practices reflecting more than one patient–provider interaction. …”
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    Variations in the quality of tuberculosis care in urban India: A cross-sectional, standardized patient study in two cities
  16. 149776
    “…The evaluation of individual responses revealed that participants with higher prescription of generics—reflected by a higher GBS—had higher incident risk of TI (mean GBS 3.61 for TI vs. 2.96 for no TI; p < 0.001). …”
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    The Role of Prescribing Generic (Non-proprietary) Drugs in the Prevalence of Therapeutic Inertia in Multiple Sclerosis Care
  17. 149777
    “…This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 634 270. This article reflects only the authors' view and the Commission is not responsible for any use that may be made of the information it contains. …”
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    Cost-effectiveness of exercise referral schemes enhanced by self-management strategies to battle sedentary behaviour in older adults: protocol for an economic evaluation alongside the SITLESS three-armed pragmatic randomised controlled trial
  18. 149778
    “…Serum miR-99a-5p expression levels were significantly decreased after EOC surgeries (1.8 to 1.3, p = 0.002), indicating that miR-99a-5p reflects tumor burden. Treatment with EOC-derived exosomes significantly increased miR-99a-5p expression in HPMCs. …”
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    Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells
  19. 149779
    “…The reduction of ryanodine receptor 2 (RyR2) stable subunits (Casq2, triadin, and junctin) rather than RYR2 and the increase in CaMKII, phosphor-CaMKII, phosphor-RyR2 (Ser 2814), SERCA, and NCX1.1 was reflected in the R33Q group. Conclusion: This study demonstrates that the increase in spontaneous calcium elevations corresponding to ITi that may trigger the oscillation in membrane potentials in the R33Q group, thereby increasing the risk of AF. …”
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    Calcium-Mediated Oscillation in Membrane Potentials and Atrial-Triggered Activity in Atrial Cells of Casq2(R33Q/R33Q) Mutation Mice
  20. 149780
    “…Eighteen studies were rated as high quality, although heterogeneity was high (I(2) = 99.7%, P < 0.001) reflecting variable data sources and study designs. …”
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    Global and regional child deaths due to injuries: an assessment of the evidence
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