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  1. 48261
    “…In this study, we used an optomechanical sensor to investigate the elasticity of auricular cartilage ECM and tested whether sensitivity and measurement reproducibility of the sensor would be sufficient to accurately detect (subtle) differences in matrix compositions in healthy, diseased, or regenerated cartilage. METHODS: As a surrogate model to different cartilage ECM compositions, goat ears (n = 9) were subjected to different degradation processes to remove the matrix components elastin and glycosaminoglycans. …”
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    Noninvasive Measurement of Ear Cartilage Elasticity on the Cellular Level: A New Method to Provide Biomechanical Information for Tissue Engineering
  2. 48262
    “…The catalytic cycle starting from the Cu(II)–Cu(II) dinuclear complex proceeds via (a) one-electron oxidation of the active catalyst by NFSI to generate an imidyl radical and dinuclear Cu(II)–Cu(III) intermediate, (b) turnover-limiting single-electron-transfer (SET1) from the arene to the imidyl radical, (c) fast C–N bond formation with an imidyl anion and an aryl radical cation, (d) reduction of the Cu(II)–Cu(III) dinuclear intermediate by the aryl radical to regenerate the active catalyst and produce an aryl-cation intermediate, and (e) deprotonation and rearomatization of the arene ring to form the imidated product. …”
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    Cu-Catalyzed aromatic C–H imidation with N-fluorobenzenesulfonimide: mechanistic details and predictive models
  3. 48263
    “…Our study has provided new ways to create a variety of self-organized 3D multicellular architectures for regenerating biomaterial and tissues in a Turing mechanism-based approach. …”
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    Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels
  4. 48264
    “…The wound healing process initiates after injury to a tissue and involves a series of orchestrated events to minimize the invasion of foreign matters such as bacteria and efficiently regenerate the damaged tissue. A variety of cells must be recruited to the tissue during wound healing. …”
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    TGF-β1 Pretreatment Improves the Function of Mesenchymal Stem Cells in the Wound Bed
  5. 48265
    por Benzle, Kyle, Cornish, Katrina
    Publicado 2017
    “…In root propagable species transformed roots are able to regenerate into whole plants without the addition of exogenous hormones, thus avoiding somaclonal variation associated with many plant transformation protocols. …”
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    Improved axenic hydroponic whole plant propagation for rapid production of roots as transformation target tissue
  6. 48266
    “…During successive culture, the CD73(high) population regenerated both CD73(high) and CD73(low) cells, whereas the CD73(low) population remained low expression level of CD73. …”
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    Ecto-5′-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells
  7. 48267
    por Liao, Rong-Zhen, Siegbahn, Per E. M.
    Publicado 2015
    “…The deoxygenation of epoxide to regenerate benzoyl-CoA by a diferrous form of the enzyme proceeds via a stepwise mechanism. …”
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    Mechanism and selectivity of the dinuclear iron benzoyl-coenzyme A epoxidase BoxB
  8. 48268
    “…These differentiating keratinocytes progressively stratify and form a self‐regenerating multi‐layered barrier that protects the underlying dermis. …”
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    Modulation of basal cell fate during productive and transforming HPV‐16 infection is mediated by progressive E6‐driven depletion of Notch
  9. 48269
    “…Recombinant IFN-I or IFN-I expression induced by RIG-I promoted growth of intestinal organoids in vitro and production of the antimicrobial peptide regenerating islet–derived protein 3 γ (RegIIIγ). Our findings were not confined to RIG-I/MAVS signaling because targeted engagement of the STING (stimulator of interferon genes) pathway also protected gut barrier function and reduced GVHD. …”
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    RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury
  10. 48270
    “…Regenerating islet-derived protein 3 alpha (REG3A) is a biomarker of lower gastrointestinal graft-versus-host disease (GVHD); however, the biological role of REG3A in the pathophysiology of GVHD is not understood. …”
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    High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype
  11. 48271
    “…X-rays, micro-computed tomography, mechanical testing, histology and immunohischemistry examinations were used to exam the quality of the regenerates. The alkaline phosphatase, calcium deposits, and steogenic markers in the PBE treated rBMSCs were significantly increased. …”
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    Porcine brain extract promotes osteogenic differentiation of bone marrow derived mesenchymal stem cells and bone consolidation in a rat distraction osteogenesis model
  12. 48272
    “…The ability for tumors to regenerate following treatment can be more aggressive, and this may be due to the remaining lung cancer-specific stem cells, which are resistant to chemotherapeutic drugs. …”
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    Expression profile of Oct-4 lung cancer-specific marker prior and subsequent to a salirasib treatment regime
  13. 48273
    “…Neural cells are considered non-regenerable, which highly restrict their application in the treatment for nerve injury. …”
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    Direct reprogramming of mouse fibroblasts into neural cells via Porphyra yezoensis polysaccharide based high efficient gene co-delivery
  14. 48274
    “…Improving the gonadal somatic niche could regenerate non-functional gonads from endogenous VSELs to restore fertility. …”
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    Making gametes from alternate sources of stem cells: past, present and future
  15. 48275
    “…The LGR5(+) stem cells are located in the crypt base and capable of regenerating all intestinal epithelial cell lineages. …”
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    The tankyrase inhibitor G007-LK inhibits small intestine LGR5(+) stem cell proliferation without altering tissue morphology
  16. 48276
    “…Treatment with H(2)O(2) or NaOCl in the presence of BSH resulted in reversible Gap inactivation due to S-bacillithiolation, which could be regenerated by the bacilliredoxin Brx (SAUSA300_1321) in vitro. …”
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    Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress
  17. 48277
    “…SUMMARY OF BACKGROUND DATA: Adult stem cell therapy is expected to definitively cure FI by regenerating damaged sphincter. Preclinical data and results of open-label trials suggest that myoblast therapy may represent a noninvasive treatment option. …”
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    Autologous Myoblasts for the Treatment of Fecal Incontinence: Results of a Phase 2 Randomized Placebo-controlled Study (MIAS)
  18. 48278
    “…The transparent corneal epithelium is regenerated by limbal stem cells (LSCs), whose loss/dysfunction results in LSCs deficiency (LSCD). …”
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    Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial‐Like Cells
  19. 48279
    “…RESULTS: Data showed that nicotine inhibited cartilage repair function by suppressing SRY-type high-mobility group box 9 (Sox9) in regenerated tissues. Further in vitro study demonstrated that nicotine enhanced intracellular Ca(2+) and activity of calcineurin (CaN) through α7-nAChR, increased the nucleic expressions of NFATc2 and the bindings to SOX9 promoter, and thus reduced the acetylation of H3K9 and H3K14 in SOX9 promoter. …”
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    Histone hypo-acetylation of Sox9 mediates nicotine-induced weak cartilage repair by suppressing BMSC chondrogenic differentiation
  20. 48280
    “…The heart of a newborn mouse has an exceptional capacity to regenerate from myocardial injury that is lost within the first week of its life. …”
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    Characterizing the Key Metabolic Pathways of the Neonatal Mouse Heart Using a Quantitative Combinatorial Omics Approach
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