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439481por Marini, Sandro, Crawford, Katherine, Morotti, Andrea, Lee, Myung J., Pezzini, Alessandro, Moomaw, Charles J., Flaherty, Matthew L., Montaner, Joan, Roquer, Jaume, Jimenez-Conde, Jordi, Giralt-Steinhauer, Eva, Elosua, Roberto, Cuadrado-Godia, Elisa, Soriano-Tarraga, Carolina, Slowik, Agnieszka, Jagiella, Jeremiasz M., Pera, Joanna, Urbanik, Andrzej, Pichler, Alexander, Hansen, Björn M., McCauley, Jacob L., Tirschwell, David L., Selim, Magdy, Brown, Devin L., Silliman, Scott L., Worrall, Bradford B., Meschia, James F., Kidwell, Chelsea S., Testai, Fernando D., Kittner, Steven J., Schmidt, Helena, Enzinger, Christian, Deary, Ian J., Rannikmae, Kristiina, Samarasekera, Neshika, Salman, Rustam Al-Shahi, Sudlow, Catherine L., Klijn, Catharina J. M., van Nieuwenhuizen, Koen M., Fernandez-Cadenas, Israel, Delgado, Pilar, Norrving, Bo, Lindgren, Arne, Goldstein, Joshua N., Viswanathan, Anand, Greenberg, Steven M., Falcone, Guido J., Biffi, Alessandro, Langefeld, Carl D., Woo, Daniel, Rosand, Jonathan, Anderson, Christopher D.“…Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. …”
Publicado 2019
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439482por Healy, Genevieve Nissa, Goode, Ana D, Abbott, Alison, Burzic, Jennifer, Clark, Bronwyn K, Dunstan, David W, Eakin, Elizabeth G, Frith, Matthew, Gilson, Nicholas D, Gao, Lan, Gunning, Lynn, Jetann, Jodie, LaMontagne, Anthony D, Lawler, Sheleigh P, Moodie, Marjory, Nguyen, Phuong, Owen, Neville, Straker, Leon, Timmins, Perri, Ulyate, Lisa, Winkler, Elisabeth A H“…Recruitment will target sectors (small business, rural or regional, call center, blue collar, and government) that are of priority to the policy and practice partners. …”
Publicado 2020
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439483por Imamura, Fumiaki, Fretts, Amanda M., Marklund, Matti, Ardisson Korat, Andres V., Yang, Wei-Sin, Lankinen, Maria, Qureshi, Waqas, Helmer, Catherine, Chen, Tzu-An, Virtanen, Jyrki K., Wong, Kerry, Bassett, Julie K., Murphy, Rachel, Tintle, Nathan, Yu, Chaoyu Ian, Brouwer, Ingeborg A., Chien, Kuo-Liong, Chen, Yun-yu, Wood, Alexis C., del Gobbo, Liana C., Djousse, Luc, Geleijnse, Johanna M., Giles, Graham G., de Goede, Janette, Gudnason, Vilmundur, Harris, William S., Hodge, Allison, Hu, Frank, Koulman, Albert, Laakso, Markku, Lind, Lars, Lin, Hung-Ju, McKnight, Barbara, Rajaobelina, Kalina, Riserus, Ulf, Robinson, Jennifer G., Samieri, Cecilia, Senn, Mackenzie, Siscovick, David S., Soedamah-Muthu, Sabita S., Sotoodehnia, Nona, Sun, Qi, Tsai, Michael Y., Tuomainen, Tomi-Pekka, Uusitupa, Matti, Wagenknecht, Lynne E., Wareham, Nick J., Wu, Jason H. Y., Micha, Renata, Lemaitre, Rozenn N., Mozaffarian, Dariush, Forouhi, Nita G.“…Heterogeneity was seen across cohorts (I(2) = 51.1%–73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94–1.13). …”
Publicado 2020
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439484por Chen, Yalei, Sadasivan, Sudha M., She, Ruicong, Datta, Indrani, Taneja, Kanika, Chitale, Dhananjay, Gupta, Nilesh, Davis, Melissa B., Newman, Lisa A., Rogers, Craig G., Paris, Pamela L., Li, Jia, Rybicki, Benjamin A., Levin, Albert M.“…Six race-differentiated SCNAs common to breast and prostate found at chromosomes 5q11.2-q14.1, 5q15-q21.1, 8q21.11-q21.13, 8q21.3-q24.3, 11q22.3, and 13q12.3-q21.3 had consistent differences by race across both tumor types, and all six were of higher magnitude in AAs, with the chromosome 8q regions being the only amplifications. Higher magnitude copy number differences in AAs were also identified at two of these race-differentiated SCNAs in two additional hormonally-driven tumor types: endometrial (8q21.3-q24.3 and 13q12.3-q21.3) and ovarian (13q12.3-q21.3) cancers. …”
Publicado 2020
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439485por Sun, Cheng-Cao, Zhu, Wei, Li, Shu-Jun, Hu, Wei, Zhang, Jian, Zhuo, Yue, Zhang, Han, Wang, Juan, Zhang, Yu, Huang, Shao-Xin, He, Qi-Qiang, Li, De-Jia“…RNA pull-down followed by dot-blot, protein domain mapping, and RNA electrophoresis mobility shift assay (EMSA) were conducted to identify the detailed binding regions between LINC00301 and EZH2. Alpha assay was conducted to quantitatively assess the interaction between LINC00301 and EZH2. …”
Publicado 2020
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439486por Argaw, Mesele Damte, Desta, Binyam Fekadu, Kibret, Mengistu Asnake, Abebe, Melkamu Getu, Heyi, Wubishet Kebede, Mamo, Elias, Gebru, Tesfaye, Gelan, Chala, Tefera, Bekele Belayhun, Bele, Temesgen Ayehu“…METHODS: This explanatory sequential mixed method study design was conducted from October 2018 to September 2019, in Amhara, Oromia, Southern, Nations, Nationalities and Peoples’ (SNNP) and Tigray regions. The quantitative research approach used an observational design which consists of three measurements: at baseline (October 2018), midterm (March 2019) and end-line (September 2019), and the qualitative approach employed a case study. …”
Publicado 2020
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439487por Eleje, George Uchenna, Mbachu, Ikechukwu Innocent, Ogwaluonye, Uchenna Chukwunonso, Kalu, Stephen Okoroafor, Onubogu, Chinyere Ukamaka, Nweje, Sussan Ifeyinwa, Uzochukwu, Chinwe Elizabeth, Nwankwo, Chike Henry, Fiebai, Preye Owen, Loto, Olabisi Morebise, Akaba, Godwin Otuodichinma, Usman, Hadiza Abdullahi, Rabiu, Ayyuba, Egeonu, Richard Obinwanne, Igue, Odion Emmanuel, Adesoji, Bukola Abimbola, Jibuaku, Chiamaka Henrietta, Aja, Prince Ogbonnia, Chidozie, Chiamaka Perpetua, Ibrahim, Hadiza Sani, Aliyu, Fatima Ele, Numan, Aisha Ismaila, Okoro, Ogbonna Dennis, Omoruyi, Solace Amechi, Oppah, Ijeoma Chioma, Anyang, Ubong Inyang, Ahmed, Aishat, Chukwurah, Shirley Nneka, Umeononihu, Osita Samuel, Chukwuanukwu, Rebecca Chinyelu, Umeh, Eric Okechukwu, Emeka, Ekene Agatha, Ogbuagu, Chukwuanugo Nkemakonam, Yakasai, Ibrahim Adamu, Ezechi, Oliver Chukwujekwu, Ikechebelu, Joseph Ifeanyichukwu“…BACKGROUND: Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. …”
Publicado 2020
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439488por Tamiru, Animut Tagele, Rade, Bayew Kelkay, Taye, Eden Bishaw, Azene, Zelalem Nigussie, Merid, Mehari Woldemariam, Muluneh, Atalay Goshu, Kassa, Getahun Molla, Yenit, Melaku Kindie, Taddese, Asefa Adimasu, Gelaye, Kassahum Alemu, Geberu, Demiss Mulatu, Tilahun, Sewbesew Yitayih, Mekonnen, Habtamu Sewunet, Azagew, Abere Woretaw, Webneh, Chalachew Adugna, Belay, Getaneh Mulualem, Assimamaw, Nega Tezera, Agegnehu, Chilot Desta, Azale, Telake, Andualem, Zewudu, Dagne, Henok, Gashaye, Kiros Terefe, Kabito, Gebisa Guyasa, Mekonnen, Tesfaye Hambisa, Daba, Sintayehu, Azanaw, Jember, Adane, Tsegaye, Alemayehu, Mekuriaw“…Therefore, efforts on community mobilization through regional/national mass media and other information conveying platforms are recommended.…”
Publicado 2020
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439489por Bermejo-Martin, Jesús F., González-Rivera, Milagros, Almansa, Raquel, Micheloud, Dariela, Tedim, Ana P., Domínguez-Gil, Marta, Resino, Salvador, Martín-Fernández, Marta, Ryan Murua, Pablo, Pérez-García, Felipe, Tamayo, Luis, Lopez-Izquierdo, Raúl, Bustamante, Elena, Aldecoa, César, Gómez, José Manuel, Rico-Feijoo, Jesús, Orduña, Antonio, Méndez, Raúl, Fernández Natal, Isabel, Megías, Gregoria, González-Estecha, Montserrat, Carriedo, Demetrio, Doncel, Cristina, Jorge, Noelia, Ortega, Alicia, de la Fuente, Amanda, del Campo, Félix, Fernández-Ratero, José Antonio, Trapiello, Wysali, González-Jiménez, Paula, Ruiz, Guadalupe, Kelvin, Alyson A., Ostadgavahi, Ali Toloue, Oneizat, Ruth, Ruiz, Luz María, Miguéns, Iria, Gargallo, Esther, Muñoz, Ioana, Pelegrin, Sara, Martín, Silvia, García Olivares, Pablo, Cedeño, Jamil Antonio, Ruiz Albi, Tomás, Puertas, Carolina, Berezo, Jose Ángel, Renedo, Gloria, Herrán, Rubén, Bustamante-Munguira, Juan, Enríquez, Pedro, Cicuendez, Ramón, Blanco, Jesús, Abadia, Jesica, Gómez Barquero, Julia, Mamolar, Nuria, Blanca-López, Natalia, Valdivia, Luis Jorge, Fernández Caso, Belén, Mantecón, María Ángeles, Motos, Anna, Fernandez-Barat, Laia, Ferrer, Ricard, Barbé, Ferrán, Torres, Antoni, Menéndez, Rosario, Eiros, José María, Kelvin, David J.“…Viral RNA detection and quantification in plasma was performed using droplet digital PCR, targeting the N1 and N2 regions of the SARS-CoV-2 nucleoprotein gene. The association between SARS-CoV-2 RNAemia and viral RNA load in plasma with severity was evaluated by multivariate logistic regression. …”
Publicado 2020
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439490por Sanchez, Katherine, Kim, Isaac, Chun, Brie, Pucilowska, Joanna, Redmond, William L., Urba, Walter J., Martel, Maritza, Wu, Yaping, Campbell, Mary, Sun, Zhaoyu, Grunkemeier, Gary, Chang, Shu Ching, Bernard, Brady, Page, David B.“…METHODS: Serial tissue was obtained from a recent clinical trial evaluating loco-regional cytokine delivery as a strategy to promote immune cell infiltration and activation in breast tumors. …”
Publicado 2021
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439491por Tumbo, Anneth-Mwasi, Schindler, Tobias, Dangy, Jean-Pierre, Orlova-Fink, Nina, Bieri, Jose Raso, Mpina, Maximillian, Milando, Florence A., Juma, Omar, Hamad, Ali, Nyakarungu, Elizabeth, Chemba, Mwajuma, Mtoro, Ali, Ramadhan, Kamaka, Olotu, Ally, Makweba, Damas, Mgaya, Stephen, Stuart, Kenneth, Perreau, Matthieu, Stapleton, Jack T., Jongo, Said, Hoffman, Stephen L., Tanner, Marcel, Abdulla, Salim, Daubenberger, Claudia“…RESULTS: The prevalence of HPgV-1 was 29.2% (28/96) and sequence analysis of the 5′ UTR and E2 regions revealed the predominance of genotypes 1, 2 and 5. …”
Publicado 2021
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439492por Baumgardt, Johanna, Schwarz, Julian, Bechdolf, Andreas, Nikolaidis, Konstantinos, Heinze, Martin, Hamann, Johannes, Holzke, Martin, Längle, Gerhard, Richter, Janina, Brieger, Peter, Kilian, Reinhold, Timm, Jürgen, Hirschmeier, Constance, Von Peter, Sebastian, Weinmann, Stefan“…METHODS/DESIGN: The presented naturalistic, quasi-experimental cohort study will evaluate IEHT in ten hospitals running IEHT services in different German regions. Within a multi-method research approach, it will evaluate stakeholders’ experiences of care, service use, efficacy, costs, treatment processes and implementation processes of IEHT from different perspectives. …”
Publicado 2021
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439493por Liu, Shuiqiao, Zhou, Mi, Ruan, Zhi, Wang, Yanan, Chang, Calvin, Sasaki, Masayuki, Rajaram, Veena, Lemoff, Andrew, Nambiar, Kalyani, Wang, Jennifer E., Hatanpaa, Kimmo J., Luo, Weibo, Dawson, Ted M., Dawson, Valina L., Wang, Yingfei“…AIF3 splicing in mouse brain caused enlarged ventricles and severe neurodegeneration in the forebrain regions. These AIF3 splicing mice died 2–4 months after birth. …”
Publicado 2021
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439494por Xu, Long, Sun, Haidan, Zhang, Yang, Guo, Zhengguang, Xiao, Xiaoping, Zhou, Xin, Hu, Kun, Sun, Wei, Wang, Bo, Liu, Weiming“…BACKGROUND: The human brain is the most complex organ in the body, and it is important to have a better understanding of how the protein composition in the brain regions contributes to the pathogenesis of associated neurological disorders. …”
Publicado 2021
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439495por Vignier, Nicolas, Bouchaud, Olivier, Angheben, Andrea, Bottieau, Emmanuel, Calleri, Guido, Salas-Coronas, Joaquín, Martin, Charlotte, Ramos, José Manuel, Mechain, Matthieu, Rapp, Christophe, Nothdurft, Hans-Dieter, Velasco, Maria, Bardají, Azucena, Rojo-Marcos, Gerardo, Visser, Leo G., Hatz, Christoph, Bisoffi, Zeno, Jelinek, Tomas, Duparc, Stephan, Bourhis, Yann, Tommasini, Silva, Iannucelli, Maurizio, Bacchieri, Antonella, Mattera, Giovan Giuseppe, Merlo Pich, Emilio, Behrens, Ronald H.“…BACKGROUND: European travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac issues, of artenimol (previously dihydroartemisinin)–piperaquine (APQ) Eurartesim(®) during treatment of uncomplicated imported falciparum malaria is not adequately described due to the lack of longitudinal studies in this population. …”
Publicado 2021
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439496por Royse, Sarah K., Minhas, Davneet S., Lopresti, Brian J., Murphy, Alice, Ward, Tyler, Koeppe, Robert A., Bullich, Santiago, DeSanti, Susan, Jagust, William J., Landau, Susan M.“…With this pipeline, we derived SUVR-to-CL transformations using the Global Alzheimer’s Association Interactive Network data; we used reference regions for cross-sectional (whole cerebellum) and longitudinal (subcortical white matter, brain stem, whole cerebellum) analyses. …”
Publicado 2021
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439497“…TRIAL REGISTRATION: Norwegian Regional Committee for Medical and Health Research Ethics (REC) 2017/573, Clinical Trials NCT03286374, registered 18. …”
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439498por Doran, Simon J., Kumar, Santosh, Orton, Matthew, d’Arcy, James, Kwaks, Fenna, O’Flynn, Elizabeth, Ahmed, Zaki, Downey, Kate, Dowsett, Mitch, Turner, Nicholas, Messiou, Christina, Koh, Dow-Mu“…From these, 92 patients were identified for whom T2-weighted, diffusion-weighted and contrast-enhanced T1-weighted sequences were available, as well as key clinicopathological variables. Regions-of-interest were drawn on the above image types and, from these, semantic and calculated radiomics features were derived. …”
Publicado 2021
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439499por Mahittikorn, Aongart, Masangkay, Frederick Ramirez, Kotepui, Kwuntida Uthaisar, Milanez, Giovanni De Jesus, Kotepui, Manas“…The results of the study may provide benefits in the management of Plasmodium-mixed infection in co-endemic regions. METHODS: This systematic review and meta-analysis searched the international Prospective Register of Systematic Reviews (PROSPERO; ID = CRD42020199709), MEDLINE, Web of Science, and Scopus for potentially relevant studies in any language published between January 1, 1936, and July 20, 2020, assessing drug efficacy in patients with Plasmodium-mixed infection. …”
Publicado 2021
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439500por Mukherjee, Koel, Sur, Debpali, Singh, Abhijeet, Rai, Sandhya, Das, Neeladrisingha, Sekar, Rakshanya, Narindi, Srinu, Dhingra, Vandana Kumar, Jat, Bhinyaram, Balraam, K. V. Vinu, Agarwal, Satya Prakash, Mandal, Prabhat Kumar“…This particular type of cancer considers one of the most aggressive malignancies to control because of its frequent local invasions to the regional lymph node. Although several biomarkers have been reported, the key marker used to predict the behavior of the disease is largely unknown. …”
Publicado 2021
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