“…She presented with a diffuse slightly urticated indurated plaques over the face, scalp, neck, back, abdomen and axillary/upper arm regions, with some minimal surface scale. A suspicion of a connective tissue disease (CTD) was raised; a skin biopsy was taken. …”
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“…This suggests that in the DG the most sensitive targets may be GABA-ergic inhibitory neurons that regulate granular cell excitability. (28)Si ion effects appear to be associated with dendro-somatic coupling expected to affect signaling of the hippocampal neurons to other brain structures and vary between rostral and ventral hippocampal regions. Observations on MCATtg mice show attenuation of radiation-elicited responses, which implicates reactive oxygen species as mediators of the biological responses. …”
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“…Because of the high accuracy of host identification for about 80% of the wasp species studied, it was possible to analyze host relationships at a regional level. The ACG species of Apanteles attack mainly species of Hesperiidae, Elachistidae and Crambidae (Lepidoptera). …”
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“…Among 66 families from several regions in Poland with a strong aggregation of breast/ovarian cancer, founder mutation of the BRCA1 gene were disclosed in 34 families and of the BRCA2 gene in on family. …”
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“…It is now clear that human sperm express several different phosphodiesterases and these are compartmentalized at different regions of the cells. By using type-specific PDEIs, differential modulation of sperm motility may be achieved without adversely affecting other functions such as the acrosome reaction (AR). …”
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“…Electrophysiology experiments on sperm from Patient 1 showed a near absence of CatSper current and exon screening demonstrated no mutations in the coding regions of the CatSper complex. There was no increase in penetration of viscous media when the spermatozoa were stimulated with progesterone and importantly there was failed fertilization at IVF. …”
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“…. •  Standardized seroepidemiological surveys to assess the impact of influenza in a population could help to establish well‐characterized banks of age‐stratified representative sera as a national, regional and global resource, while providing direct evidence of the specific benefits of vaccination. •  Advances in high‐throughput genetic sequencing coupled with advanced bioinformatics tools, together with more X‐ray crystallographic data, should accelerate understanding of the genetic and phenotypic changes that underlie virus evolution and more specifically help to predict the influence of amino acid changes on virus antigenicity. •  Complex mathematical modelling techniques are increasingly being used to gain insights into the evolution and epidemiology of influenza viruses. …”
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“…Subgroup analysis showed that eradication rates were significantly improved in both adults (RR = 1.14, 95% CI: 1.09–1.19, P<0.00001) and children (RR = 1.24, 95% CI: 1.05–1.47, P = 0.01) in the probiotic supplementation group and that no regional differences between Europe (RR = 1.17, 95% CI: 1.09–1.24, P<0.00001) and Asia were present (RR = 1.14, 95% CI: 1.06–1.22, P = 0.0002). …”
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“…METHODS: After IRB approval, a retrospective study of patients 45 years and older was performed using our Regional Level 1 Trauma Center registry data between June 2003 and December 2013. …”
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“…LIMITATIONS, REASONS FOR CAUTION: Overall evidence is generally low to moderate quality, requiring significantly greater research in this neglected, yet common condition, especially around refining specific diagnostic features in PCOS. Regional health system variation is acknowledged and a process for guideline and translation resource adaptation is provided. …”
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“…METHODS AND FINDINGS: In a 2×2×2 factorial open-label parallel-group trial, treatment-naive adults, adolescents, and children >5 years old infected with HIV, with cluster of differentiation 4 (CD4) <100 cells/mm(3), from eight urban/peri-urban HIV clinics at regional hospitals in Kenya, Malawi, Uganda, and Zimbabwe were randomised 1:1 to initiate standard triple-drug ART, with or without 12-week raltegravir intensification, and followed for 48 weeks. …”
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“…He was started on methotrexate alongside prednisolone and referred to the regional GCA centre for tocilizumab therapy.  DISCUSSION: The frequency of ophthalmic complications in GCA is quoted to be as high as 30%. …”
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“…Multi-level bilateral vertebral artery stenosis was seen on CT angiogram at the regional hyper-acute stroke unit and diagnosed as atheromatous in origin due to: a negative right-sided temporal artery biopsy, no GCA symptoms and modest inflammatory markers (CRP in the 30s and ESR in the 20s).  …”
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“…Such a framework could be potentially used in cities worldwide, including those of less developed regions or countries. Data availability, taking into account equity issues, strenghtening the communication between experts, decision makers and citizens, and the involvement of all major stakeholders are crucial elements for the HiAP approach to translate knowledge into SDG implementation.…”
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“…The 5th percentile for SpO(2) was in reasonable agreement with the WHO definition of hypoxaemia in all regions except for Peru (the highest altitude site). …”
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“…SUMMARY ANSWER: We found no statistically significant differences in the mean DNA methylation status of differentially methylated regions (DMRs) associated with parentally imprinted genes in placentas derived from IVF conceptions cultured in HTF versus G5 culture medium. …”
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“…MATÉRIELS ET MÉTHODES: Cette étude de cohorte rétrospective a été conduite durant le mois d’avril 2020 dans 2 CHU métropolitains de 2 régions différentes. Les critères d’inclusion étaient un âge > 18 ans, une infection documentée à SARS-CoV-2 et l’absence de contre-indication à la prise de TMX. …”
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“…Parmi eux, 6 patients présentaient un foyer bactérien (pulmonaire, digestif ou urinaire) objectivé ; 4 présentaient une pneumopathie interstitielle bilatérale, pour laquelle une antibiothérapie était recommandée par notre centre expert régional ; 1 patient de 17 ans était à risque d’immunodépression, traité par adalimumab. …”
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“…More nuanced 90–90–90 estimates within provinces, specifically looking at more granular sub-national level (e.g. districts), are needed to identify gaps in specific regions and to inform provincial interventions.…”
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“…Since 2010, sub-Saharan Africa showed accelerated gains on the UHC effective coverage index (at an average increase of 2·6% [1·9–3·3] per year up to 2019); by contrast, most other GBD super-regions had slowed rates of progress in 2010–2019 relative to 1990–2010. …”
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