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621por SHIBUYA, TADAMASA, MORI, KENICHI, SUMINO, YASUHIRO, SATO, FUMINORI, MIMATA, HIROMITSU“…Histological analysis revealed small round cells that were positive for MIC-2 expression and fluorescent in situ hybridization analysis detected a translocation involving Ewing sarcoma breakpoint region 1 at chromosome 22q12. Thus, a diagnosis of PNET of the prostate was established. …”
Publicado 2015
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622“…[Results] The BCI-FES group demonstrated significant differences in the frontopolar regions 1 and 2 attention indexes, and frontopolar 1 activation index. …”
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623por Gregoracci, Gustavo Bueno, Soares, Ana Carolina dos Santos, Miranda, Milene Dias, Coutinho, Ricardo, Thompson, Fabiano L.“…Although previous studies have described opposing states in upwelling regions, i.e., the rise of cold nutrient-rich waters and prevalence of surface warm nutrient-poor waters, few have addressed the transition from one state to the other. …”
Publicado 2015
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624por Nishizawa, Nobuyuki, Kumamoto, Yusuke, Igarashi, Kazuharu, Nishiyama, Ryo, Tajima, Hiroshi, Kawamata, Hiroshi, Kaizu, Takashi, Watanabe, Masahiko“…An Ewing sarcoma breakpoint region 1 gene 22q12 rearrangement was proven by a two-color fluorescence in situ hybridization assay. …”
Publicado 2015
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625por Jakobsson, Martin, Nilsson, Johan, Anderson, Leif, Backman, Jan, Björk, Göran, Cronin, Thomas M., Kirchner, Nina, Koshurnikov, Andrey, Mayer, Larry, Noormets, Riko, O'Regan, Matthew, Stranne, Christian, Ananiev, Roman, Barrientos Macho, Natalia, Cherniykh, Denis, Coxall, Helen, Eriksson, Björn, Flodén, Tom, Gemery, Laura, Gustafsson, Örjan, Jerram, Kevin, Johansson, Carina, Khortov, Alexey, Mohammad, Rezwan, Semiletov, Igor“…New and previously mapped glacial landforms together reveal flow of a spatially coherent, in some regions >1-km thick, central Arctic Ocean ice shelf dated to marine isotope stage 6 (∼140 ka). …”
Publicado 2016
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626“…The first prototype reference DNA molecule was constructed to function as a true reference DNA sequence encoding the human mitochondrial hypervariable region 1. The second DNA molecule was designed to be a molecular DNA “tag” for use in the identification of DNA Standard Reference Materials. …”
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627por Kong, Leopold, He, Linling, de Val, Natalia, Vora, Nemil, Morris, Charles D., Azadnia, Parisa, Sok, Devin, Zhou, Bin, Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Zhu, Jiang“…First, we computationally redesign a largely disordered bend in heptad region 1 (HR1) of SOSIP trimers that connects the long, central HR1 helix to the fusion peptide, substantially improving the yield of soluble, well-folded trimers. …”
Publicado 2016
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628“…RESULTS: S100B has successfully been implemented in the clinic regionally (1) to screen mild TBI patients evaluating the need to perform a head computerized tomography, (2) to predict outcome in moderate-to-severe TBI patients, (3) to detect secondary injury development in brain-injured patients and (4) to evaluate treatment efficacy. …”
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629“…Most prominent among them are Cajal-Retzius (CR) cells that emanate mainly from the cortical hem and to a lesser extent from rostrolateral, septal and caudo-medial regions. One additional territory proposed to give rise to CR cells that migrate dorsally into the neocortex lies at the ventral pallium, although contradictory results question this notion. …”
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630por Bläßle, Alexander, Soh, Gary, Braun, Theresa, Mörsdorf, David, Preiß, Hannes, Jordan, Ben M., Müller, Patrick“…These assays measure diffusion by monitoring the return of fluorescence in bleached regions (FRAP), or the dissipation of fluorescence from photoconverted regions (iFRAP). However, current FRAP/iFRAP analysis methods suffer from simplified assumptions about sample geometry, bleaching/photoconversion inhomogeneities, and the underlying reaction-diffusion kinetics. …”
Publicado 2018
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631“…High expression of the nuclear exporter chromosome maintenance region 1 (CRM1) or exportin 1 (XPO1), a common feature of several cancers including pancreatic cancer, results in excessive export of critical TSPs to the incorrect cellular compartment, leading to their functional inactivation. …”
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632“…We previously reported a large collection of structured noncoding RNAs (ncRNAs) that includes many riboswitch candidates identified through comparative sequence analysis of bacterial intergenic regions. One of these candidates, initially named the “folE motif,” adopts a simple architecture commonly found upstream of folE genes. …”
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633por Hamadou, Issa, Moula, Nassim, Siddo, Seyni, Issa, Moumouni, Marichatou, Hamani, Leroy, Pascal, Antoine-Moussiaux, Nicolas“…The Koundoum is the main wool sheep of Niger and shows a remarkable adaptation to the environment of the Niger River valley. In Tillabéri region, i.e. the Koundoum sheep's area of origin, the proportional piling tool is first used in 11 focus group discussions of breeders to determine the main selection criteria of breeding rams. …”
Publicado 2019
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634por Kirchmeier-Young, Megan C., Zwiers, Francis W., Gillett, Nathan P., Cannon, Alex J.“…For the majority of these metrics and during the current decade, the combined effect of anthropogenic and natural forcing is estimated to have made extreme fire risk events in the region 1.5 to 6 times as likely compared to a climate that would have been with natural forcings alone. …”
Publicado 2017
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635“…We show that hydrophobic sidechains at a and d positions only within the short helical segment of the C-terminal heptad-repeat region (I1161, I1165, L1168, A1172, and L1175) are critical for cell–cell fusion. …”
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636por Matsugo, Hiromichi, Kobayashi-Kitamura, Tomoya, Kamiki, Haruhiko, Ishida, Hiroho, Takenaka-Uema, Akiko, Murakami, Shin, Horimoto, Taisuke“…To validate the utility of this system, we used it to generate CAdV2 with the early region 1 gene deleted. This mutant was robustly generated and attenuated in cell culture. …”
Publicado 2020
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637por Basov, Alexander, Drobotenko, Mikhail, Svidlov, Alexandr, Gerasimenko, Eugeny, Malyshko, Vadim, Elkina, Anna, Baryshev, Mikhail, Dzhimak, Stepan“…In this paper, the new convenient approach of the analysis of the abnormal frequency of open states in different parts of the gene encoding interferon alpha 17 was presented, which took into account both rising and decreasing of them that allowed to make a prediction of the functional instability of the specific DNA regions. One advantage of the new algorithm is diminishing the number of both false positive and false negative results in data filtered by this approach compared to the pure fractile methods, such as deciles or quartiles.…”
Publicado 2020
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638por Bhardwaj, Rajesh, Lindinger, Sonja, Neuberger, Arthur, Nadezhdin, Kirill D., Singh, Appu K., Cunha, Micael R., Derler, Isabella, Gyimesi, Gergely, Reymond, Jean-Louis, Hediger, Matthias A., Romanin, Christoph, Sobolevsky, Alexander I.“…We use x-ray crystallography and cryo–electron microscopy to solve the inhibitor-bound structures of TRPV6 and identify two types of inhibitor binding sites in the transmembrane region: (i) modulatory sites between the S1-S4 and pore domains normally occupied by lipids and (ii) the main site in the ion channel pore. …”
Publicado 2020
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639“…Here, we present the characterization of the interaction between a viral protein, the Early region 1A protein from Adenovirus (E1A), and a disordered region of the human CREB-binding protein, namely the fourth intrinsically disordered linker CBP-ID4. …”
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640por Fountain-Jones, Nicholas M., Kraberger, Simona, Gagne, Roderick B., Trumbo, Daryl R., Salerno, Patricia E., Chris Funk, W., Crooks, Kevin, Biek, Roman, Alldredge, Mathew, Logan, Ken, Baele, Guy, Dellicour, Simon, Ernest, Holly B., VandeWoude, Sue, Carver, Scott, Craft, Meggan E.“…Here, we combine high resolution host and viral genomic data with landscape variables to examine the context of viral spread in puma (Puma concolor) from two contrasting regions: one bounded by the wildland urban interface (WUI) and one unbounded with minimal anthropogenic development (UB). …”
Publicado 2021
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