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641por Juraszek, Jarek, Rutten, Lucy, Blokland, Sven, Bouchier, Pascale, Voorzaat, Richard, Ritschel, Tina, Bakkers, Mark J. G., Renault, Ludovic L. R., Langedijk, Johannes P. M.“…We identify regions critical for stability: the heptad repeat region 1, the SD1 domain and position 614 in SD2. We combine a minimal selection of mostly interprotomeric mutations to create a stable S-closed variant with a 6.4-fold higher expression than the parental construct while no longer containing a heterologous trimerization domain. …”
Publicado 2021
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642“…There is an urgent need in the Middle East to increase care and support for adults with dementia and their carers, enhance research efforts and improve the dissemination of information related to dementia in the region. One possible way to do so is to begin to promote a knowledge-based culture throughout the Middle East. …”
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643“…Data reveal three themes relevant to improving engagement with HIV services in this endemic region: (1) healers have positive attitudes towards biomedicine; (2) healers advocate for their sick clients and (3) clients are reticent to present to biomedical facilities. …”
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644por Amaral, Catarina, Vicente, Cristina Teixeira, Caetano, Soraia Marques, Gaspar-Cordeiro, Ana, Yang, Yang, Cloetens, Peter, Romão, Célia V., Rodrigues-Pousada, Claudina, Pimentel, Catarina“…This work reveals that CCC1 is equipped with a complex transcriptional structure comprising several regulatory regions. One of these is located inside the coding sequence of the gene and drives the expression of a short transcript encoding an N-terminally truncated protein, designated as s-Ccc1. s-Ccc1, though less efficiently than Ccc1, is able to promote metal accumulation in the vacuole, protecting cells against iron toxicity. …”
Publicado 2021
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645“…The pipeline consists of a stepwise analysis process to extract riding behavior from a region (i.e., the fence) in a video camera feed. In the first step, the riders are identified by an Alphapose skeleton detector and tracked with a spatiotemporally aware pose tracker. …”
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646por Soukarieh, Omar, Meguerditchian, Caroline, Proust, Carole, Aïssi, Dylan, Eyries, Mélanie, Goyenvalle, Aurélie, Trégouët, David-Alexandre“…So far, they have led to numerous successes in identifying rare disease-causing mutations in coding regions, but few in non-coding regions that include introns, untranslated (UTR), and intergenic regions. One class of neglected non-coding variations is that of 5′UTR variants that alter upstream open reading frames (upORFs) of the coding sequence (CDS) of a natural protein coding transcript. …”
Publicado 2022
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647“…These genotypes practically corresponded to those defined in Japan, namely Mass, Gray, JP-II, 4/91, JP-I, JP-III, and JP-IV, which have been identified through their partial nucleotide sequences containing hypervariable regions 1 and 2. In addition, three exceptive strains were considered to be derived from recombination within the S1 gene of IBV strains G1-13 and GI-19. …”
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648por Muthusamy, Anand K., Kim, Charlene H., Virgil, Scott C., Knox, Hailey J., Marvin, Jonathan S., Nichols, Aaron L., Cohen, Bruce N., Dougherty, Dennis A., Looger, Loren L., Lester, Henry A.“…We evolved a previously reported nicotine-binding PBP to become a selective S-methadone-binding sensor, via three mutations in the PBP’s second shell and hinge regions. iS-methadoneSnFR displays the necessary sensitivity, kinetics, and selectivity—notably enantioselectivity against R-methadone—for biological applications. …”
Publicado 2022
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649por Sasaki, Makiko, Tanaka, Mamoru, Asukai, Koki, Koguchi, Hiroki, Inoue, Yusuke, Moriyama, Mizuki, Tsukahara, Tetsuo, Kawahara, Takeo, Hayashi, Eiji, Hattori, Yukinori, Hasegawa, Izumi, Kataoka, Hiromi“…The histological features of GNET overlap with those of clear cell sarcoma, which contain Ewing sarcoma breakpoint region 1 mutation. GNETs lack melanocyte‐specific markers, while clear cell sarcoma exhibits melanocytic differentiation. …”
Publicado 2022
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650“…B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved in regulating cell proliferation, differentiation and senescence, and maintaining the self-renewal of stem cells. …”
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651por Koo, Hae-Won“…She had undergone oriental acupuncture treatment in the posterior lower neck region 1 month before visiting our hospital. After the treatment, she gradually developed tinnitus, accompanied by dizziness. …”
Publicado 2022
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652por Gluschenko, K. P.“…This paper describes the methodology of aggregating the city cost-of-living indices to the regional ones and presents the results obtained for 2016–2020. …”
Publicado 2022
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653por Takagi, Yusuke, Hashimoto, Noriaki, Masuda, Hiroki, Miyoshi, Hiroaki, Ohshima, Koichi, Hontani, Hidekata, Takeuchi, Ichiro“…In medical image diagnosis, identifying the attention region, i.e., the region of interest for which the diagnosis is made, is an important task. …”
Publicado 2023
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654por Zhang, Xiaorui, Zhang, Changquan, Zhou, Di, Zhang, Tianlei, Chen, Xueqin, Ren, Jinlin, He, Caixia, Meng, Fei, Zhou, Qinwei, Yang, Qiaohui, Dai, Congling, Lin, Ge, Zeng, Sicong, Leng, Lizhi“…ATAC sequencing data revealed that the chromatin accessibility peaks on the DUX4 promoter region (i.e., the subtelomere of chromosome 4q) were transiently augmented in human minor ZGA. …”
Publicado 2023
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655por Chalabi Hagkarim, Nafiseh, Ryan, Ellis L., Byrd, Philip J., Hollingworth, Robert, Shimwell, Neil J., Agathanggelou, Angelo, Vavasseur, Manon, Kolbe, Viktoria, Speiseder, Thomas, Dobner, Thomas, Stewart, Grant S., Grand, Roger J.“…In both cases, degradation requires the action of the early region 1B55K (E1B55K) and early region 4 open reading frame 6 (E4orf6) viral proteins and is mediated through the proteasome by the action of cullin-based cellular E3 ligases. …”
Publicado 2018
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656por Vlachopapadopoulou, Elpis Athina, Dikaiakou, Eirini, Panagiotopoulos, Ioannis, Papoulidis, Ioannis, Manolakos, Emannouil, Michalacos, Stefanos“…The genetic material analysis did not show the presence of a deficit in chromosomal region 1p13.2 (chr1: 115,186,092_115,977,647) in neither of the parents, indicating that this finding was created de novo. …”
Publicado 2020
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657“…METHODS: We performed a retrospective chart review of all infants admitted to the neonatal intensive care unit (NICU) at Regional One Health from 1 January 2013 until 15 August 2019, who received diazoxide as a treatment for persistent hypoglycemia secondary to hyperinsulinism. …”
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658“…Devices fabricated using Region 1 parameters (16 Ω/sq) yielded capacitance responses of 0.78 ± 0.04 pF at 0% relative humidity (RH), increasing to 31 ± 7 pF at 85.1% RH. …”
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659por Shi, Shaobo, Tang, Yanhong, Zhao, Qingyan, Yan, Hong, Yu, Bin, Zheng, Qiangsun, Li, Yigang, Zheng, Liangrong, Yuan, Yiqiang, Zhong, Jingquan, Xu, Jian, Wu, Yanqing, Xu, Jing, Chen, Lin, Li, Shufeng, Jiang, Jian, Wang, Jingfeng, Fan, Jie, Chen, Minglong, Tang, Baopeng, Li, Wei, Wu, Qiang, Shi, Bei, Zhou, Shenghua, Zhao, Xingsheng, Yin, Yuehui, Zhang, Zheng, Zhong, Guoqiang, Han, Xuebin, Liu, Fan, Wu, Ming, Gao, Lianjun, Yang, Bo, Huang, He, Huang, Congxin“…The prevalence was higher in the central regions (2·5%, 2·3-2·7%) than in the western regions (1·5%, 1·0-2·0%) and eastern regions (1·1%, 1·0-1·2%) in the overall population, either in the gender or residency subgroups. …”
Publicado 2022
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