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  1. 20301
    por Salavaty, Abbas
    Publicado 2015
    “…Circadian rhythms refer to the endogenous rhythms that are generated to synchronize physiology and behavior with 24-h environmental cues. …”
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    Carcinogenic effects of circadian disruption: an epigenetic viewpoint
  2. 20302
    “…Fortunately, the prognostic value of examining circadian rhythms may prove useful in determining the progression of a kidney-related disease, and chronotherapy is a clinical intervention that requires consideration of circadian and diurnal rhythms in the kidney. …”
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    Circadian regulation of renal function
  3. 20303
    “…Biological rhythms can influence the activity of bioactive compounds, and at the same time, the intake of these compounds can modulate biological rhythms. …”
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    Chrononutrition and Polyphenols: Roles and Diseases
  4. 20304
    “…The circadian clock controls daily rhythms of physiological processes. The presence of the clock mechanism throughout the body is hampering its local regulation by small molecules. …”
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    Reversible modulation of circadian time with chronophotopharmacology
  5. 20305
    “…Circadian rhythms are ∼24 h cycles of organismal and cellular activity ubiquitous to mammalian physiology. …”
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    Understanding circadian regulation of mammalian cell function, protein homeostasis, and metabolism
  6. 20306
    “…We found that circadian rhythms arise following chondrogenic differentiation of miPSCs. …”
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    Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1–induced inflammation
  7. 20307
    “…Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. …”
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    Circadian disruption and sleep disorders in neurodegeneration
  8. 20308
    “…Gene targeting studies have revealed that mammalian circadian clocks generate molecular circadian rhythms through coupled transcription/translation feedback loops which involve 6 core clock genes, namely Period (Per) 1 and 2, Cryptochrome (Cry) 1 and 2, Clock, and Bmal1 and that the roles of individual clock genes in rhythms generation are tissue-specific. …”
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    Divergent Roles of Clock Genes in Retinal and Suprachiasmatic Nucleus Circadian Oscillators
  9. 20309
    por Gutierrez, Daniel, Arbesman, Joshua
    Publicado 2016
    “…Circadian rhythms are core regulators of a variety of mammalian physiologic processes and oscillate in a 24-h pattern. …”
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    Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer
  10. 20310
    “…Several lines of evidence exist demonstrating that disruption of circadian rhythms may interfere with male fertility. Experimental knock-out or knock-down of clock genes, physiologically involved in the regulation of circadian rhythms, are associated with impairments of fertility pathways in both animal and human models. …”
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    Impact of Circadian Desynchrony on Spermatogenesis: A Mini Review
  11. 20311
    por Xu, Wei, Li, Xiaodong
    Publicado 2023
    “…The intrinsic tissue clock and various extrinsic cues drive gene expression rhythms. Transcription regulation is thought to be the main driving force for gene rhythms. …”
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    Regulation of Pol II Pausing during Daily Gene Transcription in Mouse Liver
  12. 20312
    “…In the current study, we investigated the latter assumption in Cry1/2(−/−) mice, which exhibit substantially disrupted endogenous circadian rhythms and marked metabolic and behavioral deficits. …”
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    Rescue of Comorbid Behavioral and Metabolic Phenotypes of Arrhythmic Mice by Restoring Circadian Cry1/2 Expression in the Suprachiasmatic Nucleus
  13. 20313
    “…Circadian rhythms in animals are regulated at the level of individual cells and by systemic signaling to coordinate the activities of multiple tissues. …”
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    Hydrogen Peroxide Stimulates Activity and Alters Behavior in Drosophila melanogaster
  14. 20314
    “…Importantly, ∼12.4 hr cycles of swimming are sustained in constant conditions, they can be entrained by suitable stimuli, and they are temperature compensated, thereby meeting the three criteria that define a biological clock. Unexpectedly, tidal rhythms (like circadian rhythms) are sensitive to pharmacological inhibition of Casein kinase 1, suggesting the possibility of shared clock substrates. …”
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    Dissociation of Circadian and Circatidal Timekeeping in the Marine Crustacean Eurydice pulchra
  15. 20315
    por Johnston, Jonathan D.
    Publicado 2014
    “…Circadian rhythms act to optimise many aspects of our biology and thereby ensure that physiological processes are occurring at the most appropriate time. …”
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    Physiological responses to food intake throughout the day
  16. 20316
    “…It is unknown whether muscle activity and muscle clock rhythms are coupled together, nor whether activity rhythms can drive circadian gene expression in skeletal muscle. …”
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    The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle
  17. 20317
    “…However, our understanding of marine biological rhythms and their underlying molecular basis is mainly confined to a few model organisms in rather simplistic laboratory settings. …”
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    Marine biorhythms: bridging chronobiology and ecology
  18. 20318
    “…We summarize some key findings on gamma rhythms (especially their amplitude) as a biomarker or endophenotype for major depression. …”
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    Gamma oscillations as a biomarker for major depression: an emerging topic
  19. 20319
    “…These rhythms are a hallmark of normal healthy physiology, and disruption of circadian rhythms has implications for cognitive, metabolic, cardiovascular and immune function. …”
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    Telling the Time with a Broken Clock: Quantifying Circadian Disruption in Animal Models
  20. 20320
    “…Circadian rhythms have a deep impact on most aspects of physiology. …”
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    Understanding Quantitative Circadian Regulations Are Crucial Towards Advancing Chronotherapy
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