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  1. 20441
    “…We suggest that delta rhythms coordinate functional integration between operculo-insular and frontoparietal regions, while gamma rhythms reflect local sensory processing in operculo-insular areas. …”
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    Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation
  2. 20442
    “…BACKGROUND: Circadian rhythms are characterized by approximate 24-hour oscillations in physiological and behavioral processes. …”
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    Temperature as a Circadian Marker in Older Human Subjects: Relationship to Metabolic Syndrome and Diabetes
  3. 20443
    “…However, the role of mRNA surveillance via the nonsense-mediated mRNA decay (NMD) pathway in circadian rhythms remains elusive. Here, we report that Drosophila NMD pathway acts in a subset of circadian pacemaker neurons to maintain robust 24 h rhythms of free-running locomotor activity. …”
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    Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors
  4. 20444
    “…The disruption of circadian rhythms contributes to T2DM development. We investigated the effects of high-energy diet and photoperiod length on visceral and subcutaneous adipose tissue phenotype. …”
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    High-Energy Diet and Shorter Light Exposure Drives Markers of Adipocyte Dysfunction in Visceral and Subcutaneous Adipose Depots of Psammomys obesus
  5. 20445
    “…These 12-h rhythms of gene expression are cell autonomous and evolutionarily conserved in marine animals possessing a circatidal clock. …”
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    12-h clock regulation of genetic information flow by XBP1s
  6. 20446
    “…BACKGROUND & AIMS: Circadian rhythms are daily physiological oscillations driven by the circadian clock: a 24-hour transcriptional timekeeper that regulates hormones, inflammation, and metabolism. …”
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    The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation
  7. 20447
    “…INTRODUCTION: The circadian system coordinates daily rhythms in lipid metabolism, storage and utilization. …”
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    Simulated Night-Shift Schedule Disrupts the Plasma Lipidome and Reveals Early Markers of Cardiovascular Disease Risk
  8. 20448
    “…A circadian clock is present in the liver and in immortalized cell lines and temporally regulates physiological processes by driving transcriptional and metabolic rhythms. Here we investigated metabolic rhythms in HepG2 cells, a human hepatocellular carcinoma–derived cell line, and the link between these rhythms and the circadian clock in control (Bmal1-wildtype) and Bmal1-disrupted (B-D) cells having their molecular clock impaired. …”
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    “Disruption of the molecular clock severely affects lipid metabolism in a hepatocellular carcinoma cell model”
  9. 20449
    “…Additionally, altered sleep and circadian rhythms are common in people on opioid therapy. Opioids impact sleep and circadian rhythms, while disruptions to sleep and circadian rhythms likely mediate the effects of opioids. …”
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    Sex‐specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia
  10. 20450
    “…According to medical experts, these low frequency rhythms have a very important bearing on the human physiology and have potential therapeutic implications. …”
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    Studies in skin perfusion dynamics: photoplethysmography and its applications in medical diagnostics
  11. 20451
    “…Although the issue of adaptive significance of circadian rhythms has always remained central to circadian biology research, it has never been subjected to systematic and rigorous empirical validation. …”
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    Evolution of temporal order in living organisms
  12. 20452
    “…Neurochemical and electrical signaling among these oscillators is important for the normal expression of circadian rhythms. Prokineticin 2 (PK2), encoding a cysteine-rich secreted protein, has been shown to be a critical signaling molecule for the regulation of circadian rhythms. …”
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    Rhythmic Trafficking of TRPV2 in the Suprachiasmatic Nucleus is Regulated by Prokineticin 2 Signaling
  13. 20453
    “…In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. …”
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    PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
  14. 20454
    por Kohyama, Jun
    Publicado 2016
    “…This paper assesses hypothesis that sufficient sleep duration and proper circadian rhythms during the early stages of life are indispensable to a successful life. …”
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    Good daily habits during the early stages of life determine success throughout life
  15. 20455
    “…Moreover, these rhythms are entrainable (i.e. tunable by environmental stimuli), and temperature-compensated, both key features of circadian rhythms. …”
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    Circadian Clocks in Human Red Blood Cells
  16. 20456
    “…In contrast, contributions from G-coupled pathways and cytosolic rhythms to the intercellular control of SCN pacemaking are poorly understood. …”
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    A Gq-Ca(2+) Axis Controls Circuit-Level Encoding of Circadian Time in the Suprachiasmatic Nucleus
  17. 20457
    “…The hippocampal output structure, the subiculum, expresses two major memory relevant network rhythms, sharp wave ripple and gamma frequency oscillations. …”
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    Cell Type-Specific Separation of Subicular Principal Neurons during Network Activities
  18. 20458
    “…The retina and the first optic neuropil (lamina) of Drosophila show circadian rhythms in various processes. To learn about the regulation of circadian rhythms in the retina and lamina and in two cell types, glial and the lamina L2 interneurons, we examined expression of the following clock genes; per, tim, clk, and cry and clock-controlled genes (ccgs); Atpα, nrv2, brp, Pdfr. …”
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    Clock and clock-controlled genes are differently expressed in the retina, lamina and in selected cells of the visual system of Drosophila melanogaster
  19. 20459
    “…Also, systemic signals appear to be required for some transcriptional rhythms in the mammalian liver and the Drosophila fat body. …”
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    Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue
  20. 20460
    por Padmanabhan, Kiran, Billaud, Marc
    Publicado 2017
    “…Circadian clocks are innate oscillators that drive daily rhythms in metabolism, physiology, and behavior. 24-h rhythms in gene expression, driven by core clock transcription factors, reflect the epigenetic state of the cell, which in turn is dictated by the metabolic environment. …”
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    Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection
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