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  1. 21601
    “…Thalamocortical neurons are involved in the generation and maintenance of brain rhythms associated with global functional states. …”
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    Analysis of the role of the low threshold currents I(T) and I(h) in intrinsic delta oscillations of thalamocortical neurons
  2. 21602
    “…With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease.…”
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    Widespread seasonal gene expression reveals annual differences in human immunity and physiology
  3. 21603
    “…The circadian (~24 h) clock is continuously entrained (reset) by ambient light so that endogenous rhythms are synchronized with daily changes in the environment. …”
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    Light-regulated translational control of circadian behavior by eIF4E phosphorylation
  4. 21604
    “…The observed differences in circadian rhythms need to be further assessed not only in classical CSF biomarkers but also in novel forthcoming biomarkers. …”
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    Preanalytical Confounding Factors in the Analysis of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: The Issue of Diurnal Variation
  5. 21605
    “…This proposition is based on studies that indicate feed-back of vigorous wheel-running on the period and phase of circadian clocks that time daily activity rhythms. Tuco-tucos (Ctenomys aff. knighti) are subterranean rodents that are diurnal in the field but are robustly nocturnal in laboratory, with or without access to running wheels. …”
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    Nocturnal to Diurnal Switches with Spontaneous Suppression of Wheel-Running Behavior in a Subterranean Rodent
  6. 21606
    “…Whereas frequency processing starts at the level of the hearing organs, temporal features of the sound amplitude such as rhythms or pulse rates require processing by central auditory neurons. …”
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    An auditory feature detection circuit for sound pattern recognition
  7. 21607
    por Kohyama, Jun
    Publicado 2016
    “…There is a wealth of evidence that disrupted sleep and circadian rhythms, which are common in modern society even during the early stages of life, have unfavorable effects on brain function. …”
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    Neural Basis of Brain Dysfunction Produced by Early Sleep Problems
  8. 21608
    “…We found that CR significantly affected the rhythms in the expression of circadian clock genes in mice on the mRNA and protein levels, suggesting that CR reprograms the clocks both transcriptionally and post-transcriptionally. …”
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    Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms
  9. 21609
    “…An important step in understanding biological rhythms is the control of period. A multicellular, rhythmic patterning system termed the segmentation clock is thought to govern the sequential production of the vertebrate embryo's body segments, the somites. …”
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    Faster embryonic segmentation through elevated Delta-Notch signalling
  10. 21610
    “…We find that factors conventionally determining the region of tissue to resect, such as the location of focal brain lesions or the presence of epileptiform rhythms, do not necessarily predict the best resection strategy. …”
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    Estimation of brain network ictogenicity predicts outcome from epilepsy surgery
  11. 21611
    “…This is an outstanding example of how biological diel rhythms affect biogeochemical processes.…”
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    A high-resolution time-depth view of dimethylsulphide cycling in the surface sea
  12. 21612
    por Fyfe, Aileen, Moxham, Noah
    Publicado 2016
    “…Using two case studies from the Royal Society of London—Jan Ingen-Housz in 1782 and John Tyndall in 1857 to 1858—we reveal how different individuals navigated and exploited the power structures, social activities and seasonal rhythms of learned societies, all necessary precursors to gaining admission to the editorial processes of society journals, and trace the shifting significance of meetings in the increasingly competitive and diverse realm of Victorian scientific publishing. …”
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    Making public ahead of print: Meetings and publications at the Royal Society, 1752–1892
  13. 21613
    “…Using a technique that merges simultaneous multi-patch-clamp and multi-electrode array recordings of neural networks in-vitro, we show that the membrane potential of a single neuron is a reliable and super-sensitive probe for monitoring such cooperative activities and their detailed rhythms. Specifically, the membrane potential and the spiking activity of a single neuron are either highly correlated or highly anti-correlated with the time-dependent macroscopic activity of the entire network. …”
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    Simultaneous multi-patch-clamp and extracellular-array recordings: Single neuron reflects network activity
  14. 21614
    “…Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. …”
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    BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
  15. 21615
    “…Dendritic cell numbers peaked in phase with lymphocytes, with diurnal oscillations being present in disease severity after immunization to induce experimental autoimmune encephalomyelitis (EAE). These rhythms were abolished by genetic disruption of T cell clocks, demonstrating a circadian regulation of lymphocyte migration through lymph nodes with time-of-day of immunization being critical for adaptive immune responses weeks later.…”
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    Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses
  16. 21616
    por Shostak, Anton
    Publicado 2017
    “…Disruption of circadian rhythms has a profound impact on cell division and cancer development and, vice versa, malignant transformation causes disturbances of the circadian clock. …”
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    Circadian Clock, Cell Division, and Cancer: From Molecules to Organism
  17. 21617
    “…In this study, we found that learning and memory abilities were significantly reduced in rats under a simulated long-duration spaceflight environment (SLSE), which includes microgravity, isolation confinement, noises, and altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products of ginsenosides, can enhance cognition function by regulating brain neurotransmitter levels and inhibiting SLSE-induced neuronal injury. …”
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    Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight
  18. 21618
    “…To identify the precise location involved in photoperiodic response in the SCN, we analyzed circadian Period1 and PERIOD2 rhythms in horizontally sectioned SCN of mice exposed to a long or short day. …”
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    Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
  19. 21619
    “…The omics data were discussed in light of circadian rhythms and fasting/feeding. The obtained data suggest that branched-chain amino acids played a role in energy generation in the fish muscle tissues during fasting. …”
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    Trans-omics approaches used to characterise fish nutritional biorhythms in leopard coral grouper (Plectropomus leopardus)
  20. 21620
    “…It plays a role in the entrainment of the circadian rhythms of an organism by producing melatonin, a functionally important hormone. …”
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    Pineal Gland Tumor but not Pinealoma: A Case Report
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