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  1. 21521
    “…Neuroimmune endocrine impairment is found in depressed patients; high levels of circulating corticosteroids along with hyperactivation of the immune system, high levels of proinflammatory cytokines, low levels of melatonin in plasma and urine, and disentrainment of circadian rhythms have been demonstrated. Moreover, antidepressant treatment seems to correct or at least to interfere with these alterations. …”
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    Neuroimmune endocrine effects of antidepressants
  2. 21522
    “…Integrated within neural circuits, astrocytes have recently been shown to modulate brain rhythms thought to mediate sleep function. Experimental evidence suggests that local impact of astrocytes on single synapses translates into global modulation of neuronal networks and behavior. …”
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    Astrocyte regulation of sleep circuits: experimental and modeling perspectives
  3. 21523
    “…The environmental conditions that could lead to an increased risk for the development of an infection during prolonged space flight include: microgravity, stress, radiation, disturbance of circadian rhythms, and altered nutritional intake. A large body of literature exists on the impairment of the immune system by space flight. …”
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    Effect of Solar Particle Event Radiation and Hindlimb Suspension on Gastrointestinal Tract Bacterial Translocation and Immune Activation
  4. 21524
    “…It may be used in the form of differential dosing, as preparations designed to deliver sustained or pulsatile drug delivery or in the form of ‘zeitgebers’ that shift endogenous rhythms. Early trials in epilepsy suggest that chronopharmacology may provide improved seizure control compared with conventional treatment in some patients. …”
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    Chronopharmacology of Anti-Convulsive Therapy
  5. 21525
    “…Recent years have seen exciting advances in the understanding of the mechanisms that underlie circadian rhythms in a variety of organisms, including mammals. …”
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    Molecular chronobiology
  6. 21526
    “…It is evident that the knowledge that has been accumulated through chronobiology and the use of tools derived from bioinformatics has contributed to the recognition and understanding of the patterns and biological rhythms found in living organisms. The current work aims to develop new and important applications in the near future through chronobiology research.…”
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    Application of Bioinformatics in Chronobiology Research
  7. 21527
    “…This has raised the possibility that pharmacological manipulation of melanopsin can modulate several CNS responses including photophobia, sleep, circadian rhythms and neuroendocrine function. Here we describe the identification of a potent synthetic melanopsin antagonist with in vivo activity. …”
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    Small molecule antagonists of melanopsin-mediated phototransduction
  8. 21528
    “…We find that Aβ expression results in an age-related loss of circadian behavioural rhythms despite ongoing normal molecular oscillations in the central clock neurons. …”
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    The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease
  9. 21529
    “…Relations among hormone serum concentrations are complex and depend on various factors, including gender, age, body mass index, diurnal rhythms and secretion stochastics. Therefore, endocrine deviations from healthy homeostasis are not easily detected or understood. …”
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    Network Identification of Hormonal Regulation
  10. 21530
    por Secrier, Maria, Schneider, Reinhard
    Publicado 2014
    “…Furthermore, an understanding of the basic dynamics of biological phenomena that are often strictly time regulated (e.g. circadian rhythms) is needed to make accurate inferences about the evolution of biological processes. …”
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    Visualizing time-related data in biology, a review
  11. 21531
    por Laudon, Moshe, Frydman-Marom, Anat
    Publicado 2014
    “…Several melatonin receptors agonists (ramelteon, prolonged-release melatonin, agomelatine and tasimelteon) have recently become available for the treatment of insomnia, depression and circadian rhythms sleep-wake disorders. The efficacy and safety profiles of these compounds in the treatment of the indicated disorders are reviewed. …”
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    Therapeutic Effects of Melatonin Receptor Agonists on Sleep and Comorbid Disorders
  12. 21532
    por Fernando, Shavi, Rombauts, Luk
    Publicado 2014
    “…Melatonin, a pineal hormone that regulates circadian rhythms, has also been shown to exhibit unique oxygen scavenging abilities. …”
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    Melatonin: shedding light on infertility? - a review of the recent literature
  13. 21533
    “…We suggest that the inconsistencies in its presence/absence under both systematic and ecological lenses may indicate that when present it has various roles relating to behavioural and physiological rhythms.…”
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    External morphology of eyes and Nebenaugen of caridean decapods–ecological and systematic considerations
  14. 21534
    “…Robust sleep/wake rhythms are important for health and cognitive function. …”
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    Misaligned feeding impairs memories
  15. 21535
    “…These neurons are called “clock neurons” and control behavioral activity rhythms. Many clock neurons express the Cryptochrome (CRY) protein, which is sensitive to UV and blue light, and thus enables clock neurons deep in the brain to directly perceive light. …”
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    Circadian light-input pathways in Drosophila
  16. 21536
    “…These functions include circadian activities such as temperature rhythms, melatonin release and rest-activity cycles. …”
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    Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)
  17. 21537
    por Jeon, Sang Won, Kim, Yong-Ku
    Publicado 2016
    “…Beyond neuroanatomy and monoamine theory, we discuss cells and molecules, neural plasticity, neurotrophisms, endocrine mechanisms, immunological mechanisms, genetics, circadian rhythms, and metabolic regulation in depression. In addition, we introduce the possibility of new antidepressant drug development using protein translation signaling (mTOR) pathways.…”
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    Molecular Neurobiology and Promising New Treatment in Depression
  18. 21538
    por Lee, Ji Eun
    Publicado 2016
    “…Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms. Neuropeptides bind to post-synaptic receptors and elicit cellular effects like classical neurotransmitters. …”
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    Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides
  19. 21539
    “…Few models exist that accurately reproduce the complex rhythms of the thalamocortical system that are apparent in measured scalp EEG and at the same time, are suitable for large-scale simulations of brain activity. …”
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    A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation
  20. 21540
    “…Some cyanobacteria exhibit compaction of DNA in synchrony with their circadian rhythms accompanying cell division. Since the structure is transient, it has not yet been described in detail. …”
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    Ultrastructure of compacted DNA in cyanobacteria by high-voltage cryo-electron tomography
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