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23221“…Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY). …”
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23222“…BACKGROUND: The plant circadian clock orchestrates 24-hour rhythms in internal physiological processes to coordinate these activities with daily and seasonal changes in the environment. …”
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23223“…MicroRNAs (miRNAs) interact with 3′ untranslated region (UTR) elements of target genes to regulate mRNA stability or translation and thus play a role in regulating many different biological processes, including circadian rhythms. However, specific miRNAs mediating the regulation of essential clock genes remain largely unknown. …”
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23224por Mao, Liang“…The results suggest that appropriate extensions of the regular two-day weekend can be a potential measure to fight against influenza outbreaks, while minimizing interruptions on normal rhythms of socio-economy. The concept of weekend extension would be particularly useful if there were a lack of vaccine stockpiles, e.g., in countries with limited health resources, or in the case of unknown emerging infectious diseases.…”
Publicado 2011
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23225por Kasukawa, Takeya, Masumoto, Koh-hei, Nikaido, Itoshi, Nagano, Mamoru, Uno, Kenichiro D., Tsujino, Kaori, Hanashima, Carina, Shigeyoshi, Yasufumi, Ueda, Hiroki R.“…The adult mammalian brain is composed of distinct regions with specialized roles including regulation of circadian clocks, feeding, sleep/awake, and seasonal rhythms. To find quantitative differences of expression among such various brain regions, we conducted the BrainStars (B*) project, in which we profiled the genome-wide expression of ∼50 small brain regions, including sensory centers, and centers for motion, time, memory, fear, and feeding. …”
Publicado 2011
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23226“…This article also reviews therapeutic strategies used when initial treatment fails, and describes briefly new concepts in antidepressant therapies such as the regulation of disturbances in circadian rhythms. The treatment of depressive illness does not stop with treatment of acute episodes, and has to be envisaged as a continuous therapeutic intervention, of which we are still not able to determine the optimal duration of treatment and the moment that it should be ceased.…”
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23227por Scheffzük, Claudia, Kukushka, Valeriy I., Vyssotski, Alexei L., Draguhn, Andreas, Tort, Adriano B. L., Brankačk, Jurij“…BACKGROUND: The mammalian brain expresses a wide range of state-dependent network oscillations which vary in frequency and spatial extension. Such rhythms can entrain multiple neurons into coherent patterns of activity, consistent with a role in behaviour, cognition and memory formation. …”
Publicado 2011
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23228por Zoltowski, Brian D., Vaidya, Anand T., Top, Deniz, Widom, Joanne, Young, Michael W., Crane, Brian R.“…It is largely unknown how the animal CRYs that regulate circadian rhythms act on their substrates. CRYs contain a variable C-terminal tail that appends the conserved PL homology domain (PHD) and is important for function (7; 8; 9; 10; 11; 12). …”
Publicado 2011
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23229“…In addition, the neurotransmitters that ensure the intercellular coupling, and thereby the synchronization of the cellular rhythms, differ between the two main regions of the SCN. …”
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23230por Kim, Eun Bae, Fang, Xiaodong, Fushan, Alexey A., Huang, Zhiyong, Lobanov, Alexei V., Han, Lijuan, Marino, Stefano M., Sun, Xiaoqing, Turanov, Anton A., Yang, Pengcheng, Yim, Sun Hee, Zhao, Xiang, Kasaikina, Marina V., Stoletzki, Nina, Peng, Chunfang, Polak, Paz, Xiong, Zhiqiang, Kiezun, Adam, Zhu, Yabing, Chen, Yuanxin, Kryukov, Gregory V., Zhang, Qiang, Peshkin, Leonid, Yang, Lan, Bronson, Roderick T., Buffenstein, Rochelle, Wang, Bo, Han, Changlei, Li, Qiye, Chen, Li, Zhao, Wei, Sunyaev, Shamil R., Park, Thomas J., Zhang, Guojie, Wang, Jun, Gladyshev, Vadim N.“…Here we report sequencing and analysis of the NMR genome, which revealed unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness, altered visual function, circadian rhythms and taste sensing, and insensitivity to low oxygen. …”
Publicado 2011
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23231por Chen, Mengfei, Huang, Jingjing, Yang, Xuejiao, Liu, Bingqian, Zhang, Weizhong, Huang, Li, Deng, Fei, Ma, Jian, Bai, Yujing, Lu, Rong, Huang, Bing, Gao, Qianying, Zhuo, Yehong, Ge, Jian“…As is well known, retroviruses such as the Moloney murine leukemia virus (MoMLV) require cell division to integrate into the host genome and replicate, whereas the target primary cells for reprogramming are a mixture of several cell types with different cell cycle rhythms. Whether cell cycle synchronization has potential effect on retrovirus induced reprogramming has not been detailed. …”
Publicado 2012
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23232por Jepson, James E. C., Shahidullah, Mohammad, Lamaze, Angelique, Peterson, Drew, Pan, Huihui, Koh, Kyunghee“…In a forward-genetic screen, we uncovered a new component of the circadian output pathway, which we have termed dyschronic (dysc). dysc mutants exhibit arrhythmic locomotor behavior, yet their eclosion rhythms are normal and clock protein cycling remains intact. …”
Publicado 2012
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23233“…However, the same clock genes underlying circadian rhythms at the cellular level in SCN cells are also common to target cell populations of the SCN, including the GnRH neuronal network. …”
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23234por Inoue, Masahiro, Ide, Hisamitsu, Kurihara, Koji, Koseki, Tatsuro, Yu, Jingsong, China, Toshiyuki, Saito, Keisuke, Isotani, Shuji, Muto, Satoru, Horie, Shigeo“…All the patients underwent abdominal computed tomography scans and hormonal assays, including assessment of circadian rhythms of plasma cortisol and corticotropin (adrenocorticotropic hormone, ACTH), a corticotropin stimulation test, and low-dose and high-dose dexamethasone tests. …”
Publicado 2012
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23235“…Although distractor frequencies reliably biased response cycle times, this imitation bias was only a small fraction of the modulations in distractor speed, as well as of the modulations produced when participants intentionally imitated the observed rhythms. Importantly, this bias was not only present for compatible actions, but was also found, though numerically reduced, when distractor and executed actions were different (e.g., tooth brushing vs. window wiping), or when the dominant plane of movement was different (horizontal vs. vertical). …”
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23236“…The study of leaf growth movement rhythms in mature plants under biological relevant conditions, e.g. diurnal light and dark conditions, is therefore problematic. …”
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23237por Ingram, Krista K., Kutowoi, Alexander, Wurm, Yannick, Shoemaker, DeWayne, Meier, Rudolf, Bloch, Guy“…This study represents the first characterization of clock genes in an ant and is a key step towards understanding socially-regulated plasticity in circadian rhythms by facilitating comparative studies on the organization of circadian clockwork.…”
Publicado 2012
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23238por Chen, Rui, Yang, Kai, Zhao, Ning-Bo, Zhao, Dan, Chen, Dan, Zhao, Chun-Rong, Tang, Hong“…BACKGROUND: The PER1 circadian-clock gene plays an important role in the regulation of many normal physiological rhythms in vivo. It has been revealed recently that abnormal expression of PER1 correlates closely with the occurrence and development of many cancers. …”
Publicado 2012
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23239por Davies, Wayne I. L., Tay, Boon-Hui, Zheng, Lei, Danks, Janine A., Brenner, Sydney, Foster, Russell G., Collin, Shaun P., Hankins, Mark W., Venkatesh, Byrappa, Hunt, David M.“…Physiologically, this sensory system regulates the photoentrainment of many biological rhythms, such as sleep via the melatonin endocrine system and pupil constriction. …”
Publicado 2012
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23240por de la Peña, Elvira, Mälkiä, Annika, Vara, Hugo, Caires, Rebeca, Ballesta, Juan J., Belmonte, Carlos, Viana, Felix“…A characteristic feature of the hippocampal region is its expression of different electrical population rhythms and activities during different brain states. …”
Publicado 2012
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