Mostrando 261 - 280 Resultados de 734 Para Buscar '"Riboswitch"', tiempo de consulta: 0.30s Limitar resultados
  1. 261
    por Miao, Zhichao, Adamiak, Ryszard W., Antczak, Maciej, Batey, Robert T., Becka, Alexander J., Biesiada, Marcin, Boniecki, Michał J., Bujnicki, Janusz M., Chen, Shi-Jie, Cheng, Clarence Yu, Chou, Fang-Chieh, Ferré-D'Amaré, Adrian R., Das, Rhiju, Dawson, Wayne K., Ding, Feng, Dokholyan, Nikolay V., Dunin-Horkawicz, Stanisław, Geniesse, Caleb, Kappel, Kalli, Kladwang, Wipapat, Krokhotin, Andrey, Łach, Grzegorz E., Major, François, Mann, Thomas H., Magnus, Marcin, Pachulska-Wieczorek, Katarzyna, Patel, Dinshaw J., Piccirilli, Joseph A., Popenda, Mariusz, Purzycka, Katarzyna J., Ren, Aiming, Rice, Greggory M., Santalucia, John, Sarzynska, Joanna, Szachniuk, Marta, Tandon, Arpit, Trausch, Jeremiah J., Tian, Siqi, Wang, Jian, Weeks, Kevin M., Williams, Benfeard, Xiao, Yi, Xu, Xiaojun, Zhang, Dong, Zok, Tomasz, Westhof, Eric
    Publicado 2017
    “…Five puzzles, 4, 8, 12, 13, 14, all structures of riboswitch aptamers and puzzle 7, a ribozyme structure, are included in this round of the experiment. …”
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    RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme
  2. 262
    “…In bacteria, the regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformational refolding. …”
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    Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation
  3. 263
    “…The full-length translation-regulating add adenine riboswitch (Asw) from Vibrio vulnificus has a more complex conformational space than its isolated aptamer domain. …”
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    Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy
  4. 264
    “…In this review, we describe software and web servers currently available for riboswitch aptamer identification and secondary and tertiary structure prediction, including applications.…”
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    Using RNA Sequence and Structure for the Prediction of Riboswitch Aptamer: A Comprehensive Review of Available Software and Tools
  5. 265
    “…A flow cytometry high-throughput screening system was developed based on the btuB riboswitch with high efficiency to identify positive mutants. …”
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    Engineering a vitamin B(12) high-throughput screening system by riboswitch sensor in Sinorhizobium meliloti
  6. 266
    “…We conclude that this riboswitch activity leads to both student-reported increases in confidence in the ASM curriculum dimension of gene regulation, including central dogma concepts, and demonstrated student ability to diagram riboswitches, predict outcomes of riboswitches, and connect riboswitches to evolutionary roles.…”
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    Riboflavin Riboswitch Regulation: Hands-On Learning about the Role of RNA Structures in the Control of Gene Expression in Bacteria
  7. 267
    “…Many bacteria use flavin mononucleotide (FMN) riboswitches to control the expression of genes responsible for the biosynthesis and transport of this enzyme cofactor or its precursor, riboflavin. …”
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    Rare variants of the FMN riboswitch class in Clostridium difficile and other bacteria exhibit altered ligand specificity
  8. 268
    “…Thiamine pyrophosphate (TPP) riboswitch class is the most widespread riboswitch occurring in all three domains of life. …”
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    Unraveling RNA dynamical behavior of TPP riboswitches: a comparison between Escherichia coli and Arabidopsis thaliana
  9. 269
    “…We recently implemented a bioinformatics pipeline that can uncover novel, but rare, riboswitch candidates as well as other noncoding RNA structures in bacteria. …”
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    A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer
  10. 270
    “…Riboswitches can regulate gene expression by direct and specific interactions with ligands and have recently attracted interest as potential drug targets for antibacterial. …”
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    Effect of mutations on binding of ligands to guanine riboswitch probed by free energy perturbation and molecular dynamics simulations
  11. 271
    “…We present the crystal structure of the aptamer domain of this atypical cobalamin riboswitch and a model for the complete riboswitch, including its expression platform domain. …”
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    Crystal structure of an atypical cobalamin riboswitch reveals RNA structural adaptability as basis for promiscuous ligand binding
  12. 272
    por Yu, Diane, Breaker, Ronald R.
    Publicado 2020
    “…Dozens of candidate orphan riboswitch classes have been discovered previously by using comparative sequence analysis algorithms to search bacterial genomic sequence databases. …”
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    A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation
  13. 273
    “…RNAs begin to fold and function during transcription. Riboswitches undergo cotranscriptional switching in the context of transcription elongation, RNA folding, and ligand binding. …”
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    Real-time monitoring of single ZTP riboswitches reveals a complex and kinetically controlled decision landscape
  14. 274
    “…Knowledge of both apo and holo states of riboswitches aid in elucidating the various mechanisms of ligand-induced conformational “switching” that underpin their gene-regulating capabilities. …”
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    FMN riboswitch aptamer symmetry facilitates conformational switching through mutually exclusive coaxial stacking configurations
  15. 275
    “…Riboswitches are important gene regulatory elements frequently encountered in bacterial mRNAs. …”
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    Structural distinctions between NAD(+) riboswitch domains 1 and 2 determine differential folding and ligand binding
  16. 276
    “…[Image: see text] In this study, we provide experimental (Protein Data Bank (PDB) inspection) and theoretical (RI-MP2/def2-TZVP level of theory) evidence of the involvement of charge assisted chalcogen bonding (ChB) interactions in the recognition and folding mechanisms of S-adenosylmethionine (SAM) riboswitches. Concretely, an initial PDB search revealed several examples where ChBs between S-adenosyl methionine (SAM)/adenosyl selenomethionine (EEM) molecules and uracil (U) bases belonging to RNA take place. …”
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    Charge Assisted S/Se Chalcogen Bonds in SAM Riboswitches: A Combined PDB and ab Initio Study
  17. 277
    por Bao, Lei, Kang, Wen-Bin, Xiao, Yi
    Publicado 2022
    “…Riboswitches normally regulate gene expression through structural changes in response to the specific binding of cellular metabolites or metal ions. …”
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    Potential effects of metal ion induced two-state allostery on the regulatory mechanism of add adenine riboswitch
  18. 278
    “…To investigate this process, here we study the structure and function of the Bacillus subtilis yxjA purine riboswitch, a transcriptional riboswitch that downregulates a nucleoside transporter in response to binding guanine. …”
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    Cotranscriptional RNA strand exchange underlies the gene regulation mechanism in a purine-sensing transcriptional riboswitch
  19. 279
    “…Riboswitches are RNA elements involved in regulating genes that participate in the biosynthesis or transport of essential metabolites. …”
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    Antisense-acting riboswitches: A poorly characterized yet important model of transcriptional regulation in prokaryotic organisms
  20. 280
    “…Growing RNAs fold differently as they are transcribed, which modulates their finally adopted structures. Riboswitches regulate gene expression by structural change, which are sensitive to co-transcriptionally structural biology. …”
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    Observation of structural switch in nascent SAM-VI riboswitch during transcription at single-nucleotide and single-molecule resolution
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