Mostrando 281 - 300 Resultados de 734 Para Buscar '"Riboswitch"', tiempo de consulta: 0.32s Limitar resultados
  1. 281
    “…Our results show that, first, the Tte riboswitch is more thermotolerant than the Bsu riboswitch, despite only subtle sequence differences. …”
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    Single-molecule FRET observes opposing effects of urea and TMAO on structurally similar meso- and thermophilic riboswitch RNAs
  2. 282
    “…Riboswitches are genetic control elements within non-coding regions of mRNA. …”
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    Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach
  3. 283
    “…Long-range tertiary interactions determine the three-dimensional structure of a number of metabolite-binding riboswitch RNA elements and were found to be important for their regulatory function. …”
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    Dissecting the influence of Mg(2+) on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain
  4. 284
    “…[Image: see text] Riboswitches regulate gene expression via specific recognition of cognate metabolites by their aptamer domains, which fold into stable conformations upon ligand binding. …”
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    Comparison of Solution and Crystal Structures of PreQ(1) Riboswitch Reveals Calcium-Induced Changes in Conformation and Dynamics
  5. 285
    “…Riboswitch RNAs fold into complex tertiary structures upon binding to their cognate ligand. …”
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    Influence of ground-state structure and Mg(2+) binding on folding kinetics of the guanine-sensing riboswitch aptamer domain
  6. 286
    “…Here, we report the collaborative application of nuclear magnetic resonance (NMR) and replica exchange molecular dynamics (REMD) simulations to characterize the 12 nt ssRNA tail derived from the prequeuosine riboswitch. NMR carbon spin relaxation data and residual dipolar coupling measurements reveal a flexible yet stacked core adopting an A-form-like conformation, with the level of order decreasing toward the terminal ends. …”
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    Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch
  7. 287
    “…PreQ(1) riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ(1) during biosynthesis of the essential tRNA base queuosine. …”
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    Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold
  8. 288
    “…Furthermore, a series of fusions comprised of a constitutive promoter and sequences encoding variants of the synthetic tetracycline-responsive riboswitch (tc-RS) was created to characterize its influence on translation initiation in M. acetivorans. …”
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    Development of β-Lactamase as a Tool for Monitoring Conditional Gene Expression by a Tetracycline-Riboswitch in Methanosarcina acetivorans
  9. 289
    “…Riboswitches are RNA genetic control elements that were originally discovered in bacteria and provide a unique mechanism of gene regulation. …”
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    An Efficient Minimum Free Energy Structure-Based Search Method for Riboswitch Identification Based on Inverse RNA Folding
  10. 290
    “…Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. …”
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    Mechanistic Insights into Cofactor-Dependent Coupling of RNA Folding and mRNA Transcription/Translation by a Cobalamin Riboswitch
  11. 291
    por Lin, Ya-Hui, Chang, Kung-Yao
    Publicado 2016
    “…Metabolite-responsive RNA pseudoknots derived from prokaryotic riboswitches have been shown to stimulate −1 programmed ribosomal frameshifting (PRF), suggesting −1 PRF as a promising gene expression platform to extend riboswitch applications in higher eukaryotes. …”
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    Rational design of a synthetic mammalian riboswitch as a ligand-responsive -1 ribosomal frame-shifting stimulator
  12. 292
    “…Sequence and secondary structure comparisons indicated that the streptococcal riboswitch belongs to the class of tandem aptamer glycine riboswitches.…”
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    A Glycine Riboswitch in Streptococcus pyogenes Controls Expression of a Sodium:Alanine Symporter Family Protein Gene
  13. 293
    “…Riboswitches contain structured aptamer domains that, upon ligand binding, facilitate helical switching in their downstream expression platforms to alter gene expression. …”
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    Gene regulation by a glycine riboswitch singlet uses a finely tuned energetic landscape for helical switching
  14. 294
    “…In this work, we adopted a theophylline-responsive riboswitch to engineer and control glgC expression in Synechococcus elongatus PCC7942 and achieved flexible regulation of intracellular GlgC abundance and glycogen storage. …”
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    Adopting a Theophylline-Responsive Riboswitch for Flexible Regulation and Understanding of Glycogen Metabolism in Synechococcus elongatus PCC7942
  15. 295
    “…Riboswitches are naturally occurring RNA aptamers that regulate gene expression by binding to specific small molecules. …”
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    Synthetic ligands for PreQ(1) riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
  16. 296
    “…In other bacteria, Mn homeostasis is controlled by yybP-ykoY family riboswitches. Here, we characterize a yybP-ykoY family riboswitch upstream of the mgtA gene encoding a P(II)-type ATPase in S. pneumoniae, suggested previously to function in Ca(2+) efflux. …”
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    A Mn-sensing riboswitch activates expression of a Mn(2+)/Ca(2+) ATPase transporter in Streptococcus
  17. 297
    “…The widespread ykkC-I riboswitch class exemplifies divergent riboswitch evolution. …”
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    An uncommon [K(+)(Mg(2+))(2)] metal ion triad imparts stability and selectivity to the Guanidine-I riboswitch
  18. 298
    “…Here, we compared a small library of promoter–riboswitch constructs for synthetic biology applications in Anabaena sp. …”
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    Evaluation of inducible promoter–riboswitch constructs for heterologous protein expression in the cyanobacterial species Anabaena sp. PCC 7120
  19. 299
    por Hu, Guodong, Zhou, Huan-Xiang
    Publicado 2021
    “…Riboswitches are naturally occurring RNA elements that control bacterial gene expression by binding to specific small molecules. …”
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    Binding free energy decomposition and multiple unbinding paths of buried ligands in a PreQ(1) riboswitch
  20. 300
    “…Riboswitches are regulatory noncoding RNAs found in bacteria, fungi and plants, that modulate gene expressions through structural changes in response to ligand binding. …”
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    The Second Class of Tetrahydrofolate (THF-II) Riboswitches Recognizes the Tetrahydrofolic Acid Ligand via Local Conformation Changes
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