Mostrando 301 - 320 Resultados de 734 Para Buscar '"Riboswitch"', tiempo de consulta: 0.26s Limitar resultados
  1. 301
    “…The SAM-I riboswitch controls not only the biosynthesis but also the transport of SAM. …”
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    Targeting SAM-I Riboswitch Using Antisense Oligonucleotide Technology for Inhibiting the Growth of Staphylococcus aureus and Listeria monocytogenes
  2. 302
    “…Antimicrobial drug resistance has emerged as a significant challenge in contemporary medicine due to the proliferation of numerous bacterial strains resistant to all existing antibiotics. Meanwhile, riboswitches have emerged as promising targets for discovering antibacterial drugs. …”
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    Targeting FMN, TPP, SAM-I, and glmS Riboswitches with Chimeric Antisense Oligonucleotides for Completely Rational Antibacterial Drug Development
  3. 303
    “…The S-adenosylmethionine-1 (SAM-I) riboswitch mediates expression of proteins involved in sulfur metabolism via formation of alternative conformations in response to binding by SAM. …”
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    A mechanism for S-adenosyl methionine assisted formation of a riboswitch conformation: a small molecule with a strong arm
  4. 304
    “…Our experiments demonstrate that the ribB FMN riboswitch of S. davawensis (in contrast to the corresponding riboswitch of S. coelicolor) is able to discriminate between the two very similar flavins FMN and RoFMN and shows opposite responses to the latter ligands.…”
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    A highly specialized flavin mononucleotide riboswitch responds differently to similar ligands and confers roseoflavin resistance to Streptomyces davawensis
  5. 305
    “…We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. …”
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    The importance of helix P1 stability for structural pre-organization and ligand binding affinity of the adenine riboswitch aptamer domain
  6. 306
    “…Cyclic di-GMP is a ubiquitous second messenger that regulates diverse cellular processes in bacteria by binding to various protein or riboswitch effectors. In Bacillus thuringiensis BMB171, a c-di-GMP riboswitch termed Bc2 RNA resides in the 5′-untranslated region (5′-UTR) of an mRNA that encodes a collagen adhesion protein (Cap). …”
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    Cyclic di-GMP contributes to adaption and virulence of Bacillus thuringiensis through a riboswitch-regulated collagen adhesion protein
  7. 307
    “…Bacterial riboswitches are non-coding RNA structural elements that direct gene expression in numerous metabolic pathways. …”
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    Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch
  8. 308
    “…Molecular dynamics simulations and free energy calculations on the aptamer domain of the 3′,3′-cGAMP riboswitch in the ligand-free, cognate-bound and noncognate-bound states were performed to investigate the structural features of the 3′,3′-cGAMP riboswitch induced by the 3′,3′-cGAMP ligand and the specificity of ligand recognition. …”
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    Structural Studies of the 3′,3′-cGAMP Riboswitch Induced by Cognate and Noncognate Ligands Using Molecular Dynamics Simulation
  9. 309
    “…For this study, we utilized class-I and class-II preQ(1)-sensing riboswitches as model systems to decipher the structure-activity relationship of rationally designed ligand derivatives in vitro and in vivo. …”
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    Superior cellular activities of azido- over amino-functionalized ligands for engineered preQ(1) riboswitches in E.coli
  10. 310
    “…Riboswitches are structured cis-regulators mainly found in the untranslated regions of messenger RNA. …”
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    Conformational flexibility of adenine riboswitch aptamer in apo and bound states using NMR and an X-ray free electron laser
  11. 311
    “…SAM-I, SAM-I/IV, and SAM-IV are the three most commonly found SAM riboswitches, but the structure of SAM-IV is still unknown. …”
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    Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution
  12. 312
    “…Riboswitches are important model systems for the development of approaches to search for RNA-targeting therapeutics. …”
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    High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch
  13. 313
    “…Among the many in vitro-selected aptamers derived from SELEX protocols, only a small fraction has the potential to be applied for synthetic riboswitch engineering. Here, we present a comparative study of the binding properties of three different aptamers that bind to ciprofloxacin with similar K(D) values, yet only two of them can be applied as riboswitches. …”
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    What defines a synthetic riboswitch? – Conformational dynamics of ciprofloxacin aptamers with similar binding affinities but varying regulatory potentials
  14. 314
    por Xue, Yanyan, Liu, Yu
    Publicado 2022
    “…Riboswitches are natural biosensors that can regulate gene expression by sensing small molecules. …”
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    Incorporation of a FRET Pair into a Riboswitch RNA to Measure Mg(2+) Concentration and RNA Conformational Change in Cell
  15. 315
    “…Riboswitch disruption negatively impacts plant fitness. …”
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    Clock and riboswitch control of THIC in tandem are essential for appropriate gauging of TDP levels under light/dark cycles in Arabidopsis
  16. 316
    “…The yybP-ykoY family of bacterial riboswitches shares a conserved aptamer domain that binds manganese (Mn(2+)). …”
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    A riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn(2+) concentration in E. coli at alkaline pH
  17. 317
    “…Here, we have studied neomycin B binding to neomycin-sensing riboswitch aptamer constructs by native top-down mass spectrometry (MS) using electrospray ionization (ESI) and collisionally activated dissociation (CAD). …”
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    Native Top-Down Mass Spectrometry Uncovers Two Distinct Binding Motifs of a Functional Neomycin-Sensing Riboswitch Aptamer
  18. 318
    “…In contrast to other Bacillales which employ S-box riboswitches to control methionine biosynthesis, the S. aureus metICFE-mdh mRNA is preceded by a 5′-untranslated met leader RNA harboring a T-box riboswitch. …”
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    Methionine Biosynthesis in Staphylococcus aureus Is Tightly Controlled by a Hierarchical Network Involving an Initiator tRNA-Specific T-box Riboswitch
  19. 319
    “…In Staphylococcus aureus, a T-box riboswitch exists upstream of the glyS gene to regulate transcription of the sole glycyl-tRNA synthetase, which aminoacylates five tRNA(Gly) isoacceptors bearing GCC or UCC anticodons. …”
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    A glyS T-box riboswitch with species-specific structural features responding to both proteinogenic and nonproteinogenic tRNA(Gly) isoacceptors
  20. 320
    “…In bacteria, these molecules bind to RNA riboswitches and several protein receptors ultimately leading to phenotypic changes such as biofilm formation, ion transport and secretion of virulence factors. …”
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    Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches
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