“…Riboswitches are genetic control elements within non-coding regions of mRNA. …”
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“…We have determined the structure of the glutamine-II riboswitch ligand binding domain using X-ray crystallography. …”
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“…[Image: see text] Riboswitches that couple binding of ligands to conformational changes offer sensors and control elements for RNA synthetic biology and medical biotechnology. …”
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“…Glycine riboswitches utilize both single- and tandem-aptamer architectures. …”
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“…Among noncoding RNA sequences, riboswitches and ribozymes have attracted the attention of the synthetic biology community as circuit components for translation regulation. …”
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“…[Image: see text] Riboswitches are structural RNA elements that control gene expression. …”
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“…Riboswitches are structured non-coding RNAs found in the 5′ UTR of important genes for bacterial metabolism, virulence and survival. …”
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“…Riboswitches are conserved non-coding domains in bacterial mRNA with gene regulation function that are essential for maintaining enzyme co-factor metabolism. …”
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“…This effort yielded aptamers for quinine, guanine, and caffeine that appear to maintain structural features of the natural guanine riboswitch aptamer. Quinine and caffeine aptamers were each grafted onto a natural guanine riboswitch expression platform and reporter gene expression was monitored to determine that these aptamers function in cells. …”
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“…One approach that addresses this concern is the design of initial RNA pools for selection that contain structural scaffolds from naturally occurring riboswitch aptamers. Here, we provide guidance on design and experimental principles for developing riboswitch-inspired aptamers for new ligands. …”
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“…Riboswitches regulate gene expression through direct, small molecule–mRNA interactions. …”
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“…BACKGROUND: Riboswitches are a type of noncoding RNA that regulate gene expression by switching from one structural conformation to another on ligand binding. …”
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“…The adenine and guanine riboswitches regulate gene expression in response to their purine ligand. …”
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“…Riboswitches are non-coding RNAs that control gene expression by sensing small molecules through changes in secondary structure. …”
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“…Here we report the application of theophylline-sensitive synthetic riboswitches to induce protein expression in the intracellular pathogen Francisella. …”
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“…This article is part of a Special Issue entitled: Riboswitches.…”
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“…A typical class of riboswitch has its own unique structural and biological complexity, making de novo riboswitch identification a formidable task. …”
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“…In bacteria, the availability of metabolites sometimes directly regulates the expression of enzymes and proteins involved in purine salvage, biosynthesis, and uptake through riboswitches. Riboswitches are located in bacterial mRNAs and can control gene expression by conformational changes in response to ligand binding. …”
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“…Riboswitches have gained attention as tools for synthetic biology, since they enable researchers to reprogram cells to sense and respond to exogenous molecules. …”
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“…The guanidine-II riboswitch, also known as mini-ykkC, is a conserved mRNA element with more than 800 examples in bacteria. …”
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