Mostrando 601 - 620 Resultados de 734 Para Buscar '"Riboswitch"', tiempo de consulta: 0.13s Limitar resultados
  1. 601
    “…This new approach has been successfully used to study the binding of ligands to RNA molecules (e.g., SAM- and PreQ(1) riboswitches) and the identification of modifications (e.g., m(6)A) in short RNA oligos which can be written by the RNA methyltransferase METTL3/14.…”
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    Non-covalent dyes in microscale thermophoresis for studying RNA ligand interactions and modifications
  2. 602
    “…First, we describe studies that re-engineered natural riboswitches to generate new dynamic controllers. Next, we summarize RNA-based regulatory mechanisms that have been exploited to build novel artificial dynamic controllers. …”
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    RNA-based dynamic genetic controllers: development strategies and applications
  3. 603
    “…Our RNA targets include representative bacterial riboswitches that naturally bind with nanomolar affinity and high specificity to cellular metabolites of low molecular weight. …”
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    (19)F NMR‐Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter‐Screens
  4. 604
    “…By harnessing fluoride-responsive riboswitches and the orthogonal T7 RNA polymerase, biochemical reactions needed for in vivo biofluorination are wired to the presence of fluoride (i.e. circumventing the need of feeding expensive additives). …”
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    A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
  5. 605
    “…Functional nucleic acids (FNAs), such as aptamers, nucleic acid enzymes and riboswitches play essential roles in various fields of life sciences. …”
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    A versatile strategy for convenient circular bivalent functional nucleic acids construction
  6. 606
    “…Its functionality was proved as a component of hybrid Boolean gates, i.e., logic circuits that mix transcriptional and translational control (the latter reached via tetracycline-responsive riboswitches). Moreover, Cas12c activity can be strongly inhibited by the anti-CRISPR AcrVA1 protein. …”
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    Hybrid Boolean gates show that Cas12c controls transcription activation effectively in the yeast S. cerevisiae
  7. 607
    por Endoh, Tamaki, Sugimoto, Naoki
    Publicado 2013
    “…Recent findings on riboswitches emphasize on the dominative function of RNAs in regulating protein functions through allosteric interactions between RNA and protein. …”
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    Selection of RNAs for Constructing “Lighting-UP” Biomolecular Switches in Response to Specific Small Molecules
  8. 608
    “…We also identified a large number of riboswitches and cis-encoded antisense RNAs, as well as trans-encoded small noncoding RNAs that may play important roles in the gene regulation of Bacillus. …”
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    dRNA-Seq Reveals Genomewide TSSs and Noncoding RNAs of Plant Beneficial Rhizobacterium Bacillus amyloliquefaciens FZB42
  9. 609
    “…Here, we describe a new approach using secondary and tertiary structural scaffolds derived from biologically active riboswitches and small ribozymes. Applied to neurotransmitter precursors 5-hydroxytryptophan and 3,4-dihydroxyphenylalanine, this approach yields easily identifiable and characterizable aptamers predisposed for coupling to readout domains to engineer nucleic acid sensory devices that function in vitro and in the cellular context.…”
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    Recurrent RNA motifs as scaffolds for genetically encodable small molecule biosensors
  10. 610
    por Lebreton, Alice, Cossart, Pascale
    Publicado 2016
    “…We highlight how these studies have brought novel concepts in prokaryotic gene regulation, such as the ‘excludon’ where the 5′-UTR of a messenger also acts as an antisense regulator of an operon transcribed in opposite orientation, or the notion that riboswitches can regulate non-coding RNAs to integrate complex metabolic stimuli into regulatory networks. …”
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    RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression
  11. 611
    “…Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs; 3.. RNA Interactions with Proteins and Other Molecules > Small Molecule–RNA Interactions;…”
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    Natural antisense transcripts in diseases: From modes of action to targeted therapies
  12. 612
    “…It will make it possible to carry out the search for potential riboswitches in the genome of other socially important pathogens. …”
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    Search for the new potential RNA thermometers in the genome of Salmonella enterica
  13. 613
    por Yan, Fangfang, Gao, Feng
    Publicado 2020
    “…At present, many researchers are working on the discovery of viable drug and vaccine targets for bacteria through multiple methods, including the analyses of comparative subtractive genome, core genome, replication-related proteins, transcriptomics and riboswitches, which plays a significant part in the treatment of infectious and pandemic diseases. …”
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    A systematic strategy for the investigation of vaccines and drugs targeting bacteria
  14. 614
    “…We show that when seen in this framework, some naturally occurring RNAs, including ribozymes, riboswitches, viroids, viroid-like retroelements, and PIWI-interacting RNAs (piRNAs), possess several of the characteristic properties of prions.…”
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    RNAs That Behave Like Prions
  15. 615
    por Simon, Anne E., Gehrke, Lee
    Publicado 2009
    “…Unlike well characterized riboswitches in cellular RNAs, the control of infectious RNA activities by altering the configuration of functional RNA domains has only recently been recognized. …”
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    RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs
  16. 616
    “…In addition, the 5′ UTRs of 6 genes contained SAM-IV and Ykok types of riboswitches. 87 antisense RNAs and 10 intergenic small RNAs were mapped. 6 intergenic small RNAs, including 4.5S RNA and rnpB, were transcribed at extremely high levels. …”
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    RNA-Seq Analysis of Mycobacterium avium Non-Coding Transcriptome
  17. 617
    por Gardner, Paul P., Eldai, Hisham
    Publicado 2015
    “…More recent discoveries include the miRNAs and bacterial sRNAs that regulate gene expression, the thermosensors, riboswitches and other cis-regulatory elements that help prokaryotes sense their environment and eukaryotic piRNAs that suppress transposition. …”
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    Annotating RNA motifs in sequences and alignments
  18. 618
    “…The challenges that derive from trying to assign function to structure and vice versa are not trivial. Bacterial riboswitches, viral and eukaryotic IRESes, CITEs, and 3′ UTR elements employ an array of mechanisms to exert their effects. …”
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    Siblings or doppelgängers? Deciphering the evolution of structured cis-regulatory RNAs beyond homology
  19. 619
    por Skeparnias, Ilias, Zhang, Jinwei
    Publicado 2021
    “…We dissect recently structurally elucidated RNA–RNA complexes including RNA triplexes, riboswitches, ribozymes, and reverse transcription complexes. …”
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    Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions
  20. 620
    “…In the complex regulatory RNA network, riboswitches, small RNAs, and RNA thermometers can be identified as some of the key players. …”
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    Key players in regulatory RNA realm of bacteria
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