“…Transcriptional riboswitches involve RNA aptamers that are typically found in the 5′ untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures upon binding to cognate ligands. …”
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“…The riboswitch is sufficiently stable in both cell types to allow for detection of binding of the ligand to the riboswitch. …”
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“…Incapable of acquiring intermediates, the key initiations of ligand recognition in the adenine riboswitch have not been characterized. In this work, stopped-flow fluorescence was used to track structural switches in the full-length adenine riboswitch in real time. …”
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“…Importantly, the inducible plants displayed wild-type–like growth properties and riboswitch induction resulted in a further increase in astaxanthin accumulation. …”
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“…These sequences potentially harbor cis-acting riboswitches. One of the identified extended 5′ UTRs is a putative thiamine pyrophosphate (TPP) riboswitch. …”
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“…In this work, we developed a set of riboswitch-inspired riboregulators in Escherichia coli that combine the concept of toehold-mediated strand displacement (TMSD) with the switching principles of naturally occurring transcriptional and translational riboswitches. …”
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“…Likewise, only Na(+) triggers riboswitch-mediated transcription and gene expression changes. …”
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“…The expression of several Ag resistance genes has been reported to be controlled by a riboswitch mechanism encoded in a conserved sequence. …”
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“…[Image: see text] The conformational transitions of the adenosine deaminase A-riboswitch aptamer both with and without ligand binding are investigated within the tenets of the generalized Langevin equation in a complex viscoelastic cellular environment. …”
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“…The thiM riboswitch contains an aptamer domain that adaptively binds the coenzyme thiamine pyrophosphate (TPP). …”
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“…The cyclic diguanylate [bis-(3'–5')-cyclic dimeric guanosine monophosphate, c-di-GMP] riboswitch is the first known example of a gene-regulatory RNA that binds to a second messenger. …”
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“…The glmS riboswitch belongs to the family of regulatory RNAs that provide feedback regulation of metabolic genes. …”
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“…To develop the poorly explored area of RNA-ligand docking, we have conducted a virtual screening exercise for a purine riboswitch to probe the strengths and weaknesses of RNA-ligand docking. …”
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“…Riboswitches are RNAs that modulate gene expression by ligand-induced conformational changes. …”
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“…Riboswitches are a newly discovered large family of structured functional RNA elements that specifically bind small molecule targets out of a myriad of cellular metabolites to modulate gene expression. …”
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“…The ever-changing environment of a bacterial cell requires sophisticated mechanisms to adjust gene expression in response to changes in nutrient availability. L box riboswitch RNAs regulate gene expression in response to cellular lysine (lys) concentrations in the absence of additional regulatory factors. …”
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“…Riboswitches are novel RNA regulatory elements. Each riboswitch molecule consists of two domains: aptamer and express platform. …”
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“…Riboswitches are regulatory RNA elements typically located in the 5′-untranslated region of certain mRNAs and control gene expression at the level of transcription or translation. …”
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“…Riboswitches sense cellular concentrations of small molecules and use this information to adjust synthesis rates of related metabolites. …”
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