Mostrando 1 - 20 Resultados de 734 Para Buscar '"Riboswitch"', tiempo de consulta: 0.40s Limitar resultados
  1. 1
    “…The glycine riboswitch often occurs in a tandem architecture, with two ligand-binding domains (aptamers) followed by a single expression platform. …”
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    Singlet glycine riboswitches bind ligand as well as tandem riboswitches
  2. 2
    por Xu, Jiansong, Cotruvo, Joseph A.
    Publicado 2022
    “…[Image: see text] Recent work has proposed a new mechanism of bacterial iron regulation: riboswitches that undergo a conformational change in response to Fe(II). …”
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    Reconsidering the czcD (NiCo) Riboswitch as an Iron Riboswitch
  3. 3
    por Grojean, Jeremy, Downes, Brian
    Publicado 2010
    “…BACKGROUND: Riboswitches are mRNA elements that change conformation when bound to small molecules. …”
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    Riboswitches as hormone receptors: hypothetical cytokinin-binding riboswitches in Arabidopsis thaliana
  4. 4
    “…Riboswitches are commonly used by bacteria to detect a variety of metabolites and ions to regulate gene expression. …”
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    Riboswitch diversity and distribution
  5. 5
    por Tabuchi, Takeshi, Yokobayashi, Yohei
    Publicado 2021
    “…In this article, we review synthetic cell-free riboswitches that function in both prokaryotic and eukaryotic cell-free systems reported to date to provide a current perspective on the state of cell-free riboswitch technologies and their limitations.…”
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    Cell-free riboswitches
  6. 6
    “…Our results explain for the first time the molecular mechanism of an engineered riboswitch.…”
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    Mechanistic insights into an engineered riboswitch: a switching element which confers riboswitch activity
  7. 7
    “…Riboswitches are RNA sensors affecting post-transcriptional processes through their ability to bind to small molecules. …”
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    In silico investigation of riboswitches in fungi: structural and dynamical insights into TPP riboswitches in Aspergillus oryzae
  8. 8
    por Kavita, Kumari, Breaker, Ronald R.
    Publicado 2023
    “…Riboswitches are structured noncoding RNA domains used by many bacteria to monitor the concentrations of their target ligands and regulate gene expression accordingly. …”
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    Discovering riboswitches: the past and the future
  9. 9
    “…Riboswitches are functional RNA elements that regulate gene expression by directly detecting metabolites. …”
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    Riboswitches, from cognition to transformation
  10. 10
    por Hammann, Christian, Westhof, Eric
    Publicado 2007
    “…New regulatory RNAs with complex structures have recently been discovered, among them the first catalytic riboswitch, a gene-regulatory RNA sequence with catalytic activity. …”
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    Searching genomes for ribozymes and riboswitches
  11. 11
    “…While characterization of natural and synthetic riboswitches has revealed that riboswitch function can be modulated through sequence alteration, no quantitative frameworks exist to investigate or guide riboswitch tuning. …”
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    Design Principles for Riboswitch Function
  12. 12
    por Huang, Lin, Wang, Jia, Lilley, David M.J.
    Publicado 2017
    “…The guanidine-II (mini-ykkC) riboswitch is the smallest of the guanidine-responsive riboswitches, comprising two stem loops of similar sequence. …”
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    The Structure of the Guanidine-II Riboswitch
  13. 13
    “…Thus, this framework allows studying the function of natural riboswitches in silico. Moreover, it enables rationally designing artificial switches, combining essentially arbitrary sensors with a broad choice of read-out systems. …”
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    Design of Artificial Riboswitches as Biosensors
  14. 14
    “…Riboswitches are structural elements found in mRNA molecules that couple small-molecule binding to regulation of gene expression, usually by controlling transcription or translation. …”
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    Structure of the Guanidine III Riboswitch
  15. 15
    por Panchal, Vipul, Brenk, Ruth
    Publicado 2021
    “…Riboswitches reside in the untranslated region of RNA and regulate genes involved in the biosynthesis of essential metabolites through binding of small molecules. …”
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    Riboswitches as Drug Targets for Antibiotics
  16. 16
    por Breaker, Ronald R.
    Publicado 2022
    “…Over 55 distinct classes of riboswitches that respond to small metabolites or elemental ions have been experimentally validated to date. …”
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    The Biochemical Landscape of Riboswitch Ligands
  17. 17
    “…Knowledge of these regulatory mechanisms allowed us to develop synthetic corrinoid riboswitches that convert repressing riboswitches to riboswitches that robustly induce gene expression in response to corrinoids. …”
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    Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches
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    “…Knowledge of these regulatory mechanisms allowed us to develop synthetic corrinoid riboswitches that convert repressing riboswitches to riboswitches that robustly induce gene expression in response to corrinoids. …”
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    Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches
  19. 19
    “…OBJECTIVE: The purpose of this project was to use an in vivo method to discover riboswitches that are activated by new ligands. We employed phage-assisted continuous evolution (PACE) to evolve new riboswitches in vivo. …”
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    Attempted use of PACE for riboswitch discovery generates three new translational theophylline riboswitch side products
  20. 20
    “…The development of synthetic riboswitches has always been a challenge. Although a number of interesting proof-of-concept studies have been published, almost all of these were performed with the theophylline aptamer. …”
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    Next-level riboswitch development—implementation of Capture-SELEX facilitates identification of a new synthetic riboswitch
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