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Mostrando 141 - 160 Resultados de 8,631 Para Buscar '"Ron"', tiempo de consulta: 0.42s Limitar resultados
  1. 141
    “…Ron is a human receptor for the macrophage-stimulating protein (MSP). …”
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    A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene
  2. 142
    “…We report the discovery of a novel RON isoform discovered in human pancreatic cancer. …”
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    A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells
  3. 143
    “…Conversely, RON loss induces sensitivity of CRPC cells to androgen deprivation. …”
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    Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation()()
  4. 144
    “…Here, we investigated the molecular changes that occur downstream of RON activation in macrophages, and whether inhibition of RON can cooperate with checkpoint immunotherapy to eradicate tumors. …”
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    Inhibition of RON kinase potentiates anti-CTLA-4 immunotherapy to shrink breast tumors and prevent metastatic outgrowth
  5. 145
    “…In contrast, MSP, RON, and matriptase are expressed at low levels, if any, in normal pancreas. …”
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    MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC)
  6. 146
    “…Higher levels of OPN, RON and p-RON proteins were observed in tumor tissues. …”
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    OPN promotes the aggressiveness of non-small-cell lung cancer cells through the activation of the RON tyrosine kinase
  7. 147
    por Khojah, Hani MJ, Ahmed, Sameh A
    Publicado 2019
    “…OBJECTIVE: Cigarette smoking generates free radicals, such as reactive oxygen and nitrogen species (RONS) that contribute to many diseases. The aim of this study was to compare the levels of individual RONS in serum from smokers and non-smokers, and to examine their impact on lipid profiles and the endogenous antioxidant status, which is represented by vitamins C and E. …”
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    Comparative assessment of individual RONS in serum of smokers compared with non-smokers and their correlation with the lipid profile and antioxidant status
  8. 148
    “…BACKGROUND: An orally active synthetic adiponectin receptor agonist, AdipoRon has been suggested to ameliorate insulin resistance, and glucose tolerance. …”
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    AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice
  9. 149
    “…The sfRon kinase is an important therapeutic target in ovarian cancer that contributes to prominent tumor growth and disease progression. …”
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    Multi-kinase targeted therapy as a promising treatment strategy for ovarian tumors expressing sfRon receptor
  10. 150
    “…The antidiabetic adiponectin receptor agonist AdipoRon has been shown to suppress the tumour growth of human pancreatic cancer cells. …”
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    Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice
  11. 151
    “…While both AdipoRon and AdipoRonPEG5 substantially attenuate palmitate-induced lipotoxicity in INS-1 cells, only AdipoRonPEG5 treatment is accompanied by a significant reduction in cytotoxic ceramides. …”
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    PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions
  12. 152
    por Llanos, Paola, Palomero, Jesus
    Publicado 2022
    “…Skeletal muscle fibers continuously generate reactive oxygen and nitrogen species (RONS). An excess of RONS produces oxidative distress, which may evoke cellular damage and dysfunction. …”
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    Reactive Oxygen and Nitrogen Species (RONS) and Cytokines—Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle
  13. 153
    “…In this study, we investigated whether an ApN receptor agonist, AdipoRon (AR), could slow muscle dysfunction, myosteatosis and degenerative muscle markers in middle‐aged obese mice. …”
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    AdipoRon enhances healthspan in middle‐aged obese mice: striking alleviation of myosteatosis and muscle degenerative markers
  14. 154
    “…In P. falciparum, AMA1 interaction with rhoptry neck protein 2 (RON2) is known to be crucial for invasion, and PfRON2 peptides (PfRON2p) blocked the invasion of PfAMA1 wild-type parasites. …”
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    The direct binding of Plasmodium vivax AMA1 to erythrocytes defines a RON2-independent invasion pathway
  15. 155
    “…Conclusion: CPs may serve as potential markers for distinguishing between cancer cells regulated by RONS. The combination of aKG + 5-HMF showed induced cell death in high-RONS-generating cancer cells compared to low-RONS-generating cancer cells.…”
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    Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying Antitumoral Effects of Alpha-Ketoglutarate + 5-HMF
  16. 156
    “…Here we show that TgRON2 localizes to the MJ and that two short segments flanking a hydrophobic stretch near its C-terminus (D3 and D4) independently associate with the ectodomain of TgAMA1. …”
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    The C-Terminus of Toxoplasma RON2 Provides the Crucial Link between AMA1 and the Host-Associated Invasion Complex
  17. 157
    “…In contrast to C . albicans, the cluster often contains a gene for an Ndt80‐like transcription factor, which we named RON1 (regulator of N‐acetylglucosamine catabolism 1). …”
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    The N‐acetylglucosamine catabolic gene cluster in Trichoderma reesei is controlled by the Ndt80‐like transcription factor RON1
  18. 158
    “…Recepteur d’origine nantais (RON) receptor is a single-pass transmembrane RTK aberrantly expressed in a number of cancers. …”
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    Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing
  19. 159
    “…Using immunoprecipitation followed by mass spectrometry we describe here a novel protein complex we have named SURGE where SURFIN(4.2) forms interacts with the rhoptry neck protein 4 (RON4) and the Glutamate Rich Protein (GLURP). The N-terminal cysteine-rich–domain (CRD) of SURFIN(4.2) mediates binding to the RBC membrane and its interaction with RON4 suggests its involvement in the contact between the merozoite apex and the RBC at the MJ. …”
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    SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN(4.2)-RON4-GLURP) contributes to merozoite invasion
  20. 160
    “…In this review, we discuss the importance of MET and/or RON in CRAC tumorigenesis and development of anti-MET, anti-RON, and MET and RON-dual targeting antibody-drug conjugates for clinical application. …”
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    MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy
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