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Mostrando 581 - 600 Resultados de 17,537 Para Buscar '"SAM"', tiempo de consulta: 0.40s Limitar resultados
  1. 581
    “…In Caenorhabditis elegans, the N(6)-methyladenosine (m(6)A) modification by METT10, at the 3'-splice sites in S-adenosyl-l-methionine (SAM) synthetase (sams) precursor mRNA (pre-mRNA), inhibits sams pre-mRNA splicing, promotes alternative splicing coupled with nonsense-mediated decay of the pre-mRNAs, and thereby maintains the cellular SAM level. …”
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    Structure of the Caenorhabditis elegans m(6)A methyltransferase METT10 that regulates SAM homeostasis
  2. 582
    “…The dried tuber of Alisma orientale (Sam.) Juzep. (AOJ) is a traditional Chinese medicine with high medicinal value. …”
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    Diversity, chemical constituents and biological activities of endophytic fungi from Alisma orientale (Sam.) Juzep.
  3. 583
    por Namkoong, Gil, Suess, Daniel L. M.
    Publicado 2023
    “…Through a combination of inductively coupled plasma mass spectrometric and (57)Fe Mössbauer spectroscopic analysis, we show that, of the two [Fe(4)S(4)] clusters in BtrN (a Twitch-domain-containing radical S-adenosyl-l-methionine (SAM) enzyme), the Fe ions in the SAM-binding cluster undergo faster exchange with exogenous Fe(2+); the auxiliary cluster is essentially inert under the reaction conditions. …”
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    Cluster-selective (57)Fe labeling of a Twitch-domain-containing radical SAM enzyme
  4. 584
    “…In-silico analysis of radical SAM proteins is sufficient to identify novel putative sactibiotic clusters.…”
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    Genome Mining for Radical SAM Protein Determinants Reveals Multiple Sactibiotic-Like Gene Clusters
  5. 585
    “…When used to express seasonal influenza hemagglutinin (HA), a SAM vaccine elicited potent immune responses, comparable to those elicited by a licensed influenza subunit vaccine preparation. …”
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    Rapidly produced SAM(®) vaccine against H7N9 influenza is immunogenic in mice
  6. 586
    “…The structure of CmoA, a member of the SAM-dependent methyltransferase superfamily, revealed a ligand in the catalytic site consistent with Cx-SAM. …”
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    Structure-guided discovery of carboxy-SAM as a novel metabolite modulating tRNA function
  7. 587
    “…We find that ANKS3-SAM polymerizes and ANKS6-SAM can bind to one end of the polymer. …”
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    Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3
  8. 588
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    Inactivation of SAM-Methyltransferase is the Mechanism of Attenuation of a Historic Louse Borne Typhus Vaccine Strain
  9. 589
    “…The present study was designed to evaluate the antihypertensive effect of GaMiSamHwangSaSimTang (HVC1), a 30% ethanol extract of a mixture comprising Pruni Cortex, Scutellariae Radix, Coptidis Rhizoma, and Rhei Rhizoma, on spontaneous hypertensive rats (SHRs). …”
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    Antihypertensive Effect of the GaMiSamHwangSaSimTang in Spontaneous Hypertensive Rats
  10. 590
    “…Among them, seven RNA-binding proteins commonly localized in the Sam68 nuclear body (SNB), which was disrupted by RNase treatment. …”
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    The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL
  11. 591
    “…With serial cellular and biochemical assays, we demonstrated that Sam68 is recruited to and significantly overlaps with PARP1 at DNA lesions and that the interaction between Sam68 and PARP1 is crucial for DNA damage-initiated and PARP1-conferred PAR production. …”
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    Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation
  12. 592
    “…This stable carboxylic acid SAM formation could be a useful alternative to phosphonic acid SAMs for corrosion and other applications.…”
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    Effect of Alkyl Chain Length on Carboxylic Acid SAMs on Ti-6Al-4V
  13. 593
    “…Here, we study the molecular recognition mechanism of the S-adenosylmethionine SAM-I riboswitch by characterizing the formation of a helical stacking interaction involving the ligand-binding process. …”
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    Ligand recognition and helical stacking formation are intimately linked in the SAM-I riboswitch regulatory mechanism
  14. 594
    “…Among them, the emerging superfamily of radical SAM enzymes has been shown to play a major role. …”
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    Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)
  15. 595
    “…The splicing factor Sam68 is upregulated in many human cancers, including prostate cancer (PCa) where it promotes cell proliferation and survival. …”
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    c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer
  16. 596
    “…Adherence to medication was assessed using the German Stendal Adherence to Medication Score (SAMS). The SAMS questionnaire includes 18 questions forming a cumulative scale (0 – 72) in which 0 indicates complete adherence and 72 complete non-adherence. …”
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    Data on adherence to medication in neurological patients using the German Stendal Adherence to Medication Score (SAMS)
  17. 597
    “…LepI is an S-adenosylmethionine (SAM)-dependent pericyclase that catalyzes the formation of 2-pyridone natural product leporin C. …”
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    Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI
  18. 598
    “…Bioinformatics analyses revealed the presence of ultra-conserved Sam68 binding sites in SMN IRAlus. Cross-link-immunoprecipitation (CLIP), mutagenesis and silencing experiments showed that Sam68 binds in proximity of intronic Alus in the SMN pre-mRNA, thus favouring circRNA biogenesis in vitro and in vivo. …”
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    Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization
  19. 599
    por Miller, Sven A., Bandarian, Vahe
    Publicado 2019
    “…[Image: see text] S-Adenosyl-l-methionine (SAM) is the central cofactor in the radical SAM enzyme superfamily, responsible for a vast number of transformations in primary and secondary metabolism. …”
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    Analysis of Electrochemical Properties of S-Adenosyl-l-methionine and Implications for Its Role in Radical SAM Enzymes
  20. 600
    “…BACKGROUND: Sam68, an RNA-binding protein, exerts oncogenic functions in several types of cancer. …”
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    Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing
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