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12101por Liaci, Emanuela, Bach, Michael, Tebartz van Elst, Ludger, Heinrich, Sven P., Kornmeier, Jürgen“…METHODS: We presented tactile SAM stimuli and varied the ARs, while participants reported the perceived motion directions. …”
Publicado 2016
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12102“…BACKGROUND: Severe acute malnutrition (SAM) affects nearly 20 million children worldwide and is responsible for up to 1 million deaths per year in children under the age of 5 years. …”
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12103por Froese, D. Sean, Kopec, Jolanta, Rembeza, Elzbieta, Bezerra, Gustavo Arruda, Oberholzer, Anselm Erich, Suormala, Terttu, Lutz, Seraina, Chalk, Rod, Borkowska, Oktawia, Baumgartner, Matthias R., Yue, Wyatt W.“…The folate and methionine cycles are crucial for biosynthesis of lipids, nucleotides and proteins, and production of the methyl donor S-adenosylmethionine (SAM). 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a key regulatory connection between these cycles, generating 5-methyltetrahydrofolate for initiation of the methionine cycle, and undergoing allosteric inhibition by its end product SAM. …”
Publicado 2018
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12104por Corrigan, Damion K., Vezza, Vincent, Schulze, Holger, Bachmann, Till T., Mount, Andrew R., Walton, Anthony J., Terry, Jonathan G.“…To successfully and consistently functionalize the sensors, it was necessary to dilute the constituent molecules by a factor of ten thousand to support adequate SAM formation on microelectrodes. The use of this multi-electrode device therefore demonstrates in a high throughput manner irreproducibility in the SAM formation process at the higher concentration, even though these electrodes are apparently functionalized simultaneously in the same film formation environment, confirming that the often seen significant electrode-to-electrode variation in label-free SAM biosensing films formed under such conditions is not likely to be due to variation in film deposition conditions, but rather kinetically controlled variation in the SAM layer formation process at these microelectrodes.…”
Publicado 2018
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12105por Murphy, Sean V., Skardal, Aleksander, Song, Lujie, Sutton, Khiry, Haug, Rebecca, Mack, David L., Jackson, John, Soker, Shay, Atala, Anthony“…The solubilized amnion membrane (SAM) combined with the carrier hyaluronic acid (HA) hydrogel (HA‐SAM) is easy to produce, store, and apply to wounds. …”
Publicado 2017
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12106“…Community health workers (CHWs) play an important role in the detection and referral of children with severe acute malnutrition (SAM) in many countries. However, distance to health facilities remains a significant obstacle for caregivers to attend treatment services, resulting in SAM treatment coverage rates below 40% in most areas of intervention. …”
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12107por Schulze, Katharina V., Swaminathan, Shanker, Howell, Sharon, Jajoo, Aarti, Lie, Natasha C., Brown, Orgen, Sadat, Roa, Hall, Nancy, Zhao, Liang, Marshall, Kwesi, May, Thaddaeus, Reid, Marvin E., Taylor-Bryan, Carolyn, Wang, Xueqing, Belmont, John W., Guan, Yongtao, Manary, Mark J., Trehan, Indi, McKenzie, Colin A., Hanchard, Neil A.“…Edematous severe acute childhood malnutrition (edematous SAM or ESAM), which includes kwashiorkor, presents with more overt multi-organ dysfunction than non-edematous SAM (NESAM). …”
Publicado 2019
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12108por Wakita, Maiko, Yamagata, Atsushi, Shiroshima, Tomoko, Izumi, Hironori, Maeda, Asami, Sendo, Mizuki, Imai, Ayako, Kubota, Keiko, Goto-Ito, Sakurako, Sato, Yusuke, Mori, Hisashi, Yoshida, Tomoyuki, Fukai, Shuya“…Here, we report the crystal structure of the complex between mouse PTPδ D2 and Liprin-α3 tSAM at 1.91 Å resolution. PTPδ D2 interacts with the N-terminal helix and the first and second SAMs (SAM1 and SAM2, respectively) of Liprin-α3. …”
Publicado 2020
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12109“…CONTEXT: Musculoskeletal injuries are prevalent in sports, and the application of Sustain Acoustic Medicine (SAM) as a home-use add-on therapy to reduce pain and to increase the probability of athletes returning to sports was evaluated in a case series. …”
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12110por Schober, Florian A., Moore, David, Atanassov, Ilian, Moedas, Marco F., Clemente, Paula, Végvári, Ákos, Fissi, Najla El, Filograna, Roberta, Bucher, Anna-Lena, Hinze, Yvonne, The, Matthew, Hedman, Erik, Chernogubova, Ekaterina, Begzati, Arjana, Wibom, Rolf, Jain, Mohit, Nilsson, Roland, Käll, Lukas, Wedell, Anna, Freyer, Christoph, Wredenberg, Anna“…Here, we show that the one-carbon metabolite and methyl group donor S-adenosylmethionine (SAM) is pivotal for energy metabolism. A gradual decline in mitochondrial SAM (mitoSAM) causes hierarchical defects in fly and mouse, comprising loss of mitoSAM-dependent metabolites and impaired assembly of the oxidative phosphorylation system. …”
Publicado 2021
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12111por Zhong, Heju, Yuan, Peiqiang, Li, Yunxia, Batonon-Alavo, Dolores, Deschamps, Caroline, Feng, Bin, Zhang, Xiaoling, Che, Lianqiang, Lin, Yan, Xu, Shengyu, Li, Jian, Zhuo, Yong, Tian, Gang, Tang, Jiayong, Jiang, Xuemei, Huang, Lingjie, Wu, Caimei, Wu, De, Fang, Zhengfeng“…Likewise, H(2)O(2) promoted SAM synthesis and reduced SAM utilization for methylation depending on H(2)O(2) levels and treatment time in vitro. …”
Publicado 2021
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12112por Savar, Nastaran Sadat, Vallet, Thomas, Arashkia, Arash, Lundstrom, Kenneth, Vignuzzi, Marco, Mahmoudzadeh Niknam, Hamid“…The main aim was to present optimized and rapid methods for SFV-PD SAM preparation, its packaging, and titer determination. …”
Publicado 2022
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12113por Uegaki, Tesshin, Takei, Taisei, Yamaguchi, Shuhei, Fujiyama, Keisuke, Sato, Yusuke, Hino, Tomoya, Nagano, Shingo“…Here, we report the crystal structure of a SAM-dependent methyltransferase from anammox bacteria (AmxMT1) that has a substrate and active site pocket between a class I SAM methyltransferase-like core domain and an additional α-helix inserted into the core domain. …”
Publicado 2023
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12114“…Only one study replicated the WHO VA protocol in children with SAM. Indirectness was a critical limitation, as studies were not exclusive to children with SAM. …”
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12115por Kristensen, Kia Hee Schultz, Wiese, Maria, Rytter, Maren Johanne Heilskov, Özçam, Mustafa, Hansen, Lars Hestbjerg, Namusoke, Hanifa, Friis, Henrik, Nielsen, Dennis Sandris“…BACKGROUND: Severe acute malnutrition (SAM) among children remains a major health problem in many developing countries. …”
Publicado 2016
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12116por Di Giovanni, Valeria, Bourdon, Celine, Wang, Dominic X, Seshadri, Swapna, Senga, Edward, Versloot, Christian J, Voskuijl, Wieger, Semba, Richard D, Trehan, Indi, Moaddel, Ruin, Ordiz, M Isabel, Zhang, Ling, Parkinson, John, Manary, Mark J, Bandsma, Robert HJ“…Background: Mortality in children with severe acute malnutrition (SAM) remains high despite standardized rehabilitation protocols. …”
Publicado 2016
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12117por Sheppard, Allan, Ngo, Sherry, Li, Xiaoling, Boyne, Michael, Thompson, Debbie, Pleasants, Anthony, Gluckman, Peter, Forrester, Terrence“…BACKGROUND: Severe acute malnutrition (SAM) in infants may present as one of two distinct syndromic forms: non-edematous (marasmus), with severe wasting and no nutritional edema; or edematous (kwashiorkor) with moderately severe wasting. …”
Publicado 2017
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12118por Doocy, Shannon, Tappis, Hannah, Villeminot, Nicolas, Suk, Ann, Kumar, Deepak, Fazal, Shahid, Grant, Angeline, Pietzsch, Silke“…OBJECTIVE: To evaluate effectiveness of point-of-use water treatment in improving treatment of children affected by severe acute malnutrition (SAM). DESIGN: Programme sites were randomized to one of four intervention arms: (i) standard SAM treatment; (ii) SAM treatment plus flocculent/disinfectant water treatment; (iii) SAM treatment plus chlorine disinfectant; or (iv) SAM treatment plus ceramic water filter. …”
Publicado 2018
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12119por Lai, Jana, Nguyen, Cattram, Tabwaia, Beia, Nikuata, Agnes, Baueri, Nikarawa, Timeon, Eretii, Diaaldeen, Mohammed, Iuta, Tinai, Ozturk, Murat Hakan, Moore, Aaron, Hall, Alice, Nyambat, Batmunkh, Davis, Stephanie, Rahman, Ataur, Erasmus, Wendy, Fox, Kimberley, Russell, Fiona“…To estimate the impact of rotavirus vaccine on acute gastroenteritis (AGE) and severe acute malnutrition (SAM) among children under 5 in Kiribati, a retrospective review of inpatient and outpatient AGE and hospitalized SAM was undertaken. …”
Publicado 2020
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12120“…The recovery rate of children from SAM to full recovery was 75% (95% CI = 69%-81%). …”
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