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  1. 12561
    “…BACKGROUND: elPrep is an established multi-threaded framework for preparing SAM and BAM files in sequencing pipelines. To achieve good performance, its software architecture makes only a single pass through a SAM/BAM file for multiple preparation steps, and keeps sequencing data as much as possible in main memory. …”
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    A comparison of three programming languages for a full-fledged next-generation sequencing tool
  2. 12562
    “…During +SAM/La Niña periods, the at-depth overwintering period is shorter compared to −SAM/El Niño periods, and return to the surface layers starts earlier in the year. …”
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    Zooplankton and micronekton respond to climate fluctuations in the Amundsen Sea polynya, Antarctica
  3. 12563
    “…BACKGROUND: A combination of olanzapine and samidorphan (OLZ/SAM) is in development to provide the established antipsychotic efficacy of olanzapine while mitigating olanzapine-induced weight gain. …”
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    Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet
  4. 12564
    “…Our findings provide support for further investigation into the development of highly specific allosteric inhibitors of enzymatic mediators of Met/SAM metabolism or dietary manipulation of methionine levels. …”
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    Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia
  5. 12565
    “…BACKGROUND: Our aim was to investigate whether self-administration of medication (SAM) during hospitalization affects the number of dispensing errors, perceptions regarding medication, and participant satisfaction when compared with nurse-led medication dispensing. …”
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    Self-administration of medication: a pragmatic randomized controlled trial of the impact on dispensing errors, perceptions, and satisfaction
  6. 12566
    “…The data provide a preclinical proof of concept that a SAM (CNE) vaccine candidate can rapidly elicit protective immunity against ZIKV.…”
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    Development of a potent Zika virus vaccine using self-amplifying messenger RNA
  7. 12567
    “…A simple scheme of actual lipid metabolism during active SAM production in S. stipitis, grown on glycerol was constructed and shown. …”
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    Lipid Composition of Sheffersomyces stipitis M12 Strain Grown on Glycerol as a Carbon Source
  8. 12568
    “…S-adenosyl-L-methionine (SAM) donates a methyl group to EZH2 which then methylates DNA and histones leading to the abnormal gene expression responsible for AT/RT’s aggressive phenotype. …”
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    ATRT-17. TARGETING GLUTAMINE METABOLISM LOWERS METHYLATION POTENCIALS IN AT/RT AND SYNERGIZE WITH TAZEMETOSTAT
  9. 12569
    “…BACKGROUND: In India, under-five children with Severe Acute Malnutrition (SAM) are referred to Nutritional Rehabilitation Centers (NRCs). …”
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    Poor adherence to TB diagnosis guidelines among under-five children with severe acute malnutrition in central India: A missed window of opportunity?
  10. 12570
    “…By surveying Protein Data Bank with SamCC-Turbo, we generated a comprehensive atlas of ∼50 000 coiled-coil regions. …”
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    A library of coiled-coil domains: from regular bundles to peculiar twists
  11. 12571
    “…A comparison between subacute (SAM) and acute (AM) mastitis cases revealed differences related to the etiological agent (S. epidermidis in SAM; Staphylococcus aureus in AM), milk immunological profile (high content of IL10 and IL13 in SAM and IL2 in AM) and milk HMOs profile (high content of 3FL in SAM and of LNT, LNnT, and LSTc in AM). …”
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    Interactions between human milk oligosaccharides, microbiota and immune factors in milk of women with and without mastitis
  12. 12572
    “…INTRODUCTION: The current standard of care for children with severe acute malnutrition (SAM) involves using ready-to-use therapeutic food (RUTF) to promote growth; however, the precise formulation to achieve optimal recovery remains unclear. …”
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    Optimal iron content in ready-to-use therapeutic foods for the treatment of severe acute malnutrition in the community settings: a protocol for the systematic review and meta-analysis
  13. 12573
    “…We report crystal structures for the SaTrmK apoenzyme as well as in complexes with methyl donor SAM and co-product product SAH. Isothermal titration calorimetry showed that SAM binds to the enzyme with favorable but modest enthalpic and entropic contributions, whereas SAH binding leads to an entropic penalty compensated for by a large favorable enthalpic contribution. …”
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    Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m(1)A22-tRNA methyltransferase TrmK
  14. 12574
    “…Further, supplementation of obese animals with SAM sensitized pancreatic tumors to chemotherapy. …”
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    Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC
  15. 12575
    “…The protein is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes, which use SAM as a precursor to a 5′-deoxyadenosyl 5′-radical (5′-dA·). …”
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    In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1
  16. 12576
    “…These changes result from variability in the Southern Annular Mode (SAM), causing warming along the eastern SPG which affects local ecosystems. …”
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    Natural cycles in South Pacific Gyre strength and the Southern Annular Mode
  17. 12577
    “…Our analysis revealed that the WSCA in the C-BOX has been remotely modulated by the Southern Annular Mode (SAM) since the early 1990s. It is shown that the SAM shifted to its positive phase at this transition and began strongly impacting the WSCA in the C-BOX and the NEC bifurcation. …”
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    Intensified modulation of the Pacific north equatorial current bifurcation by the southern annular mode since the early 1990s
  18. 12578
    “…As these findings reveal, RquA provides an example of a non-canonical SAM-dependent enzyme that does not catalyze methyl transfer, instead it uses SAM in an atypical amino transfer mechanism.…”
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    Microbial rhodoquinone biosynthesis proceeds via an atypical RquA-catalyzed amino transfer from S-adenosyl-L-methionine to ubiquinone
  19. 12579
    “…Background: Outcomes in children hospitalised with severe acute malnutrition (SAM) remain poor. The current milk-based formulations focus on restoring weight-gain but fail to address modification of the integrity of the gut barrier and may exacerbate malabsorption owing to functional lactase, maltase and sucrase deficiency. …”
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    Development of a legume-enriched feed for treatment of severe acute malnutrition
  20. 12580
    “…We found that CIN cells are particularly sensitive to SAM metabolism at least partly because of its role in generating polyamines. …”
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    Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism
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