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12661“…The S. cerevisiae sake K6 strain, which is a Generally Recognized as Safe (GRAS) strain, was chosen as the host because it produces a significant amount of S-adenosylmethionine (SAM), a precursor of SMM. To increase SMM production in the host, MHT1 and SAM4 genes encoding homocysteine S-methyltransferase were knocked out to prevent SMM degradation. …”
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12662“…We evaluate how the SAM method performs with SNPs, which are increasingly employed due to their high number, low cost and easy of scoring. …”
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12663“…Importantly, injection of mRNA encoding the Elp3 radical SAM domain mutant, but not the HAT domain mutant, into MII oocytes before fertilization also impaired paternal DNA demethylation indicating that the SAM radical domain is involved in the demethylation process. …”
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12664por Petropoulos, George P., Vadrevu, Krishna Prasad, Xanthopoulos, Gavriil, Karantounias, George, Scholze, Marko“…In this study the potential for burnt area mapping of the combined use of Artificial Neural Network (ANN) and Spectral Angle Mapper (SAM) classifiers with Landsat TM satellite imagery was evaluated in a Mediterranean setting. …”
Publicado 2010
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12665por Tsao, Douglas, Wieskopf, Jeffrey S, Rashid, Naim, Sorge, Robert E, Redler, Rachel L, Segall, Samantha K, Mogil, Jeffrey S, Maixner, William, Dokholyan, Nikolay V, Diatchenko, Luda“…Using computational modeling, biochemical tests and cellular assays we show that serotonin actively competes with the methyl donor S-adenosyl-L-methionine (SAM) within the catalytic site. Binding of serotonin to the catalytic site inhibits the access of SAM, thus preventing methylation of COMT substrates. …”
Publicado 2012
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12666por Feng, Jun, Wu, Jun, Dai, Nan, Lin, Shuangjun, Xu, H. Howard, Deng, Zixin, He, Xinyi“…BlsE, a predicted radical S-adenosyl-L-methionine (SAM) protein, was anaerobically purified and reconstituted in vitro to study its function in the blasticidin S biosynthetic pathway. …”
Publicado 2013
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12667por Zhu, Zhenyu, Guan, Shengxi, Robinson, Derek, Fezzazi, Hanna El, Quimby, Aine, Xu, Shuang-yong“…The purified enzyme contains internally-bound S-adenosylmethionine (SAM). When the internal SAM was removed, the endonuclease activity was stimulated by adding SAM or its analog sinefungin. …”
Publicado 2014
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12668“…The Arabidopsis KNOX gene SHOOT MERISTEMLESS (STM) is required for both the development and the sustained function of the shoot apical meristem (SAM) and can induce de novo meristem formation when expressed ectopically. …”
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12669por Tebbutt, Scott J, He, Jian-Qing, Singh, Amrit, Shannon, Casey P, Ruan, Jian, Carlsten, Chris“…Data were analyzed using robust LIMMA and SAM. The cell-specific Significance Analysis of Microarrays (csSAM) algorithm was used to deconvolute the gene expression data according to cell type. …”
Publicado 2012
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12670por Wani, Ajazul H., Boettiger, Alistair N., Schorderet, Patrick, Ergun, Ayla, Münger, Christine, Sadreyev, Ruslan I., Zhuang, Xiaowei, Kingston, Robert E., Francis, Nicole J.“…We manipulated PcG clusters by disrupting the polymerization activity of the sterile alpha motif (SAM) of the PcG protein Polyhomeotic (Ph) or by increasing Ph levels. …”
Publicado 2016
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12671por Chisti, Mohammod Jobayer, Ahmed, Tahmeed, Shahid, Abu S. M. S. B., Shahunja, K. M., Bardhan, Pradip Kumar, Faruque, Abu Syeed Golam, Das, Sumon Kumar, Salam, Mohammed Abdus“…We aimed to evaluate sociodemographic, epidemiological, and clinical risk factors for pulmonary tuberculosis (PTB) in children presenting with severe acute malnutrition (SAM) and pneumonia. Children aged 0 to 59 months with SAM and radiologic pneumonia from April 2011 to July 2012 were studied in Bangladesh. …”
Publicado 2015
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12672por Meyer, Britta, Wurm, Jan Philip, Sharma, Sunny, Immer, Carina, Pogoryelov, Denys, Kötter, Peter, Lafontaine, Denis L. J., Wöhnert, Jens, Entian, Karl-Dieter“…The crystal structure of archaeal Tsr3 homologs revealed the same fold as in SPOUT-class RNA-methyltransferases but a distinct SAM binding mode. This unique SAM binding mode explains why Tsr3 transfers the acp and not the methyl group of SAM to its substrate. …”
Publicado 2016
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12673por Chisti, Mohammod Jobayer, Salam, Mohammed Abdus, Shahid, Abu S. M. S. B., Shahunja, K. M., Das, Sumon Kumar, Faruque, Abu Syed Golam, Bardhan, Pradip Kumar, Ahmed, Tahmeed“…In this prospective study, we enrolled SAM children aged <5 with radiological pneumonia. …”
Publicado 2017
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12674“…In this paper, we present a stable silver-based surface plasmon resonance (SPR) sensor using a self-assembled monolayer (SAM) as a protection layer and investigated its efficiency in water and 0.01 M phosphate buffered saline (PBS). …”
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12675“…The SAM or AS are preferably used in situations where the data for a specific predictor do not lie close to the inflection point of a circular regression curve. …”
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12676por Scofield, Simon, Murison, Alexander, Jones, Angharad, Fozard, John, Aida, Mitsuhiro, Band, Leah R., Bennett, Malcolm, Murray, James A. H.“…The Arabidopsis homeodomain transcription factor SHOOT MERISTEMLESS (STM) is crucial for shoot apical meristem (SAM) function, yet the components and structure of the STM gene regulatory network (GRN) are largely unknown. …”
Publicado 2018
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12677por Potter, Greg, Swart, Chantel W., van Wyk, Pieter W. J., Duvenhage, Mart-Mari, Coetsee, Elizabeth, Swart, Hendrik C., Budge, Suzanne M., Speers, R. Alex“…Nano scanning Auger microscopy (NanoSAM) and time-of-flight secondary ion mass spectrometry (TOF-SIMS) have been used in materials science research for some time, but NanoSAM, in particular, has only recently been applied to biological specimens. …”
Publicado 2018
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12678por Chang, Caitlin A., Wei, Xing‐Chang, Martin, Steven R., Sinasac, David S., Al‐Hertani, Walla“…Metabolic investigations demonstrated elevations in plasma methionine, plasma S‐adenosylmethionine (SAM) and plasma S‐adenosylhomocysteine (SAH), with normal urine adenosine levels. …”
Publicado 2019
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12679por Ge, Chuang-Ye, Rahman, Md. Mahbubur, Zhang, Wei, Lopa, Nasrin Siraj, Jin, Lei, Yoon, Sujin, Jang, Hohyoun, Xu, Guang-Ri, Kim, Whangi“…CYS-SAM was formed onto the FTO electrode by the adsorption of CYS molecules through the head sulfur groups. …”
Publicado 2020
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12680“…Moreover, starvation-induced autophagy was suppressed in renal cortex of Gnmt null mice and amino acid free-induced autophagy was also suppressed by administration of SAM in cultured HK-2 cells. A LPD could exert a renoprotective effect through the suppression of mTORC1 and restoration of autophagy, which is associated with reduced levels of SAM due to low-Met intake, in diabetic kidney.…”
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