“…Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor. High expression of NNMT can alter cellular NAM and SAM levels, which in turn, affects nicotinamide adenine dinucleotide (NAD(+))-dependent redox reactions and signaling pathways, and remodels cellular epigenetic states. …”
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“…In addition, a fecundity index (ratio of new-born pups to adult females at the median pupping date) was positively correlated with current-year Southern Annular Mode (SAM) conditions. Periods of positive SOI and positive SAM conditions are forecast to increase in coming decades, suggesting advantageous conditions for the Kanowna Island AUFS population.…”
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“…Cocrystallization of MET with nicotinamide (NAM), salicylamide (SAM), and 4-hydroxybenzoic acid (HBA) resulted in multicomponent solids that were characterized by PXRD, DSC and single crystal X-ray diffraction. …”
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“…Secondly, SAM-derived compounds are being investigated for their ability to act as inhibitors of RNA MTases. …”
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“…We found that R882H mutation induces a “folded” conformation in the methyl donor S-adenosylmethionine (SAM) through different types of hydrogen bond formation at the terminal carbonyl oxygen atom and the hydroxyl O3′ atom of the ribose ring on SAM, with Arg891 as a mediator. …”
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“…DNA methylation appeared to be involved in the resumption in the SAM-mediated cell cycle because its downstream metabolite S-adenosylhomocysteine failed to cause either cell cycle progression or ferroptosis to be induced. …”
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“…DC., Dioscorea japonica Thunb., Cornus officinalis Siebold and Zucc., Poria cocos Wolf, Paeonia suffruticosa Andrews, Alisma plantago-aquatica subsp. orientale (Sam.) Sam., Achyranthes bidentate Blume, and Plantago asiatica L. …”
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“…Dynamic left ventricular outflow tract obstruction (LVOTO) has classically been observed in patients with hypertrophic obstructive cardiomyopathy (HOCM) where it occurs secondary to asymmetric septal hypertrophy and systolic anterior motion (SAM) of the mitral valve. However, there are some instances that lead to hypercontractility of the myocardium, and with a combination of other physiological conditions, result in SAM of a mitral valve leaflet, leading to LVOTO in the absence of phenotype. …”
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“…Severe Acute Malnutrition (SAM) is a serious public health problem in many low- and middle-income countries (LMICs). …”
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“…CONCLUSIONS: The predisposition to and nature of LVOTO due to SAM were associated with the bioprosthetic valve interstrut distance subtending the fully retained AML and may explain the survival differences in such patients. …”
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“…The unique experimental design allowed for ECM, ISM, and SAM to concurrently determine the contents of cocaine on banknotes collected around Metro‐Detroit. …”
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“…Among them, the Self-Assessment Manikin (SAM) devised by Lang is one of the most popular. …”
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“…Therefore, a comparative study on the surface protection of a quaternary 18K gold alloy and pure gold substrates by SAMs of 6-mercaptopurine (6MP), 1-decanethiol (DT), and 11-mercaptoundecanoic acid (MUA) has been carried out. …”
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“…Most of the fly ash concrete mixtures had a satisfactory air void system immediately after mixing, but the SAM number showed an increasing trend over time, suggesting the coarsening of the air void system with time.…”
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“…It was found that both molecules could bind to the S-Adenosyl methionine (SAM) binding pocket and prevent the SAM entrance co-substrate, which could eventually halt the function of MTase. …”
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“…The data demonstrate the relationships between SAM, glutathione, pectins, and Cu(II) in the induction medium and how they affect GPRE. …”
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“…We explored the solvent-exposed edge of the SAM adenosine moiety and systematically designed 42 analogs of adenosine carrying substituents at the C6-amino group (N6) of adenosine. …”
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“…This case highlights that in low-income countries amoebiasis, especially in children with SAM, may result in life-threatening complications. …”
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