“…This is a rare and much-needed book: a concise but comprehensive account of quantum mechanics for popular science readers written by a respected physicist. Sam Treiman--internationally renowned for his work in particle physics--makes quantum mechanics accessible to nonspecialists. …”
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“…Preoperative administration of S‐adenosylmethionine (SAM) could hypomethylate the NR2B gene, upregulate NR2B expression and improve LTP, exerting a dose‐dependent therapeutic effect against PND. …”
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“…In silico protein modeling shows that these mutations may affect the affinity of PRMT5 for S-adenosylmethionine (SAM), which is required as a methyl donor. Electrostatic analysis of the enzyme active site shows that one of these mutations creates a tunnel in the vicinity of the SAM binding site, which may allow interfering molecules to enter the enzyme active site and decrease its activity. …”
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“…Here, we report biotransformation of the most abundant C6 sulfonamido precursors in 3M AFFF with available commercial standards (FHxSA, PFHxSAm, and PFHxSAmS) in microcosms representative of the groundwater/surface water boundary. …”
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“…The results showed that NO decreased the activity of S-adenosylmethionine synthase and S-adenosylhomocysteine hydrolase and increased the activity of methionine sulfoxide reductase A, as well as the content of N5-methyl-THF, the ratio of tetrahydrofolate (THF), homocysteine, methionine, S-adenosylmethionine (SAM), and SAM to S-adenosylhomocysteine compared with the control, indicating that NO effectively increased FOCM flux by affecting the activity of FOCM enzymes. …”
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“…Sequence and structural analyses of the two encoded proteins identified a conserved S-adenosyl methionine (SAM) binding domain, showing they are SAM-dependent MTases phylogenetically related to human METTL16 and Arabidopsis thaliana FIONA1. …”
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“…BACKGROUND: The reduction in severe and moderate acute malnutrition (SAM and MAM) rates in Pakistan has been sub-optimal compared to other low-and middle-income countries (LMICs). …”
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“…NNMT acts on either the SAM-methylation balance or both NAD(+) metabolism, depending on the tissue involved or pathological settings where metabolic demand is increased. …”
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“…Benefiting from SAM, multi-level semantics can be selectively propagated to predict precise salient objects. …”
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“…The nuclear METTL3-METTL14 enzyme complex transfers a methyl group from S-adenosyl-L-methionine (SAM) to the N(6) amino group of an adenosine (A) base in RNA to convert it to m(6)A and in ssDNA to 6mA. m(6)A marks are prevalent in eukaryotic mRNAs and lncRNAs and modulate their stability and fate in a context-dependent manner. …”
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“…Second, we mine a family of bacterial HMTs from Pseudomonas species sharing less than 50% sequence identities with known HMTs and evaluated their activities in SAM regeneration. Our best performing HMT from P. aeruginosa, PaHMT, displays the highest SAM regeneration efficiencies (TTN up to 7,700) among HMTs characterized to date. …”
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“…PRMT5 utilises the universal methyl donor S-adenosylmethionine (SAM) to methylate arginine residues of protein substrates and regulate their activity, notably histones to regulate transcription. …”
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“…To date, validations have primarily targeted the hypothalamic–pituitary–adrenal axis, when the sympathetic–adrenal–medullary (SAM) system is likely the primary driver of vasomotor activity during acute stress. …”
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“…We report the growth of N-polar InGaN layers on misoriented ScAlMgO(4) (SAM) substrates with offset of 0.3 to 5.8° toward the m-plane. …”
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“…Structural characterization demonstrated that the P450 catalyzed a biaryl C-C crosslink formation between two Tyr residues. The B12-rSAM generated β-methyltyrosine, while the MNIO transformed a C-terminal Asp residue into a C-terminal aminopyruvic acid. …”
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“…Scanning acoustic microscopy (SAM) detects the attenuation of sound (AOS) through sections. …”
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“…Using Significance Analysis of Microarrays (SAM), we further searched for genes that show correlating expression with PIK3CA. …”
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“…Sera obtained from senescence-accelerated mouse (SAM) and normal mice contained a substance that reacted with antiserum raised against ASSAM, a novel senile amyloid fibril protein isolated from the liver of SAM. …”
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“…The identification of three enzymes involved in S-adenosylmethionine (SAM) metabolism furthermore suggests that redox control is required to balance the metabolic fluxes of SAM between methyl-group transfer reactions and polyamine synthesis. …”
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