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  1. 14221
    “…MS activity was dependent upon methylcobalamin (MeCbl) or the combination of hydroxocobalamin (OHCbl) and S-adenosylmethionine (SAM). OHCbl-based activity was eliminated by depletion of the antioxidant glutathione (GSH) but could be rescued by provision of either glutathionylcobalamin (GSCbl) or MeCbl. …”
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    Alternatively Spliced Methionine Synthase in SH-SY5Y Neuroblastoma Cells: Cobalamin and GSH Dependence and Inhibitory Effects of Neurotoxic Metals and Thimerosal
  2. 14222
    “…It is uniquely found in Rossmann enzymes that use different cofactors, primarily SAM (S-adenosyl methionine), NAD (nicotinamide adenine dinucleotide), and FAD (flavin adenine dinucleotide). …”
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    An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors
  3. 14223
    “…Support for the contribution of altered epigenetic mechanisms in the down-regulation of RELN expression in corticolimbic structures of psychotic patients includes the concomitant increase of DNA-methyltransferases and the increased levels of the methyl donor S-adenosylmethionine (SAM). It is hypothesized that these conditions lead to RELN promoter hypermethylation and a reduction in RELN protein amounts in psychotic patients. …”
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    Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders
  4. 14224
    por Du, Zhiyong, Wu, Changli
    Publicado 2016
    “…Immunohistochemistry: Vimentin (+), CK7 (+), Pax8 (−), SAM partial (+), P504s weak (+), TFE3 partial (+), ER (−), PR (+), Ki67 <1% positive tumor cells. …”
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    AB181. Analysis of clinical and pathological features of mixed epithelial and stromal tumor of the kidney
  5. 14225
    “…The stem cells in the shoot apical meristem (SAM) are the origin of all above ground tissues in plants. …”
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    OBE3 and WUS Interaction in Shoot Meristem Stem Cell Regulation
  6. 14226
    por Lee, Seo Yeon, Ko, Kwang Suk
    Publicado 2016
    “…METHODS: RAW 264.7 macrophage cells and seven-week-old male C57BL/6 mice were pretreated with SAMe (SAM or AdoMet), taurine, and/or betaine. In order to mimic hepatic injury like endotoxemia or viral infection, cells and mice were treated with LPS or polyI:C. …”
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    Protective Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine Against Lipopolysaccharide or Polyinosinic-polycytidylic Acid-induced Acute Hepatotoxicity
  7. 14227
    “…Here, we investigated molecular mechanism of androgen-dependent expression of AIbZIP and its physiological function in prostate cancer cells. Our data showed that SAM pointed domain-containing ETS transcription factor (SPDEF), which is upregulated by androgen treatment, directly activates transcription of AIbZIP. …”
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    The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression
  8. 14228
    “…Here we report a hierarchical surface modification strategy, first by coating a gold surface with a self-assembled monolayer (SAM) designed to attract or probe for analytes and then by grafting a non-fouling zwitterionic polymer brush layer to effectively repel protein fouling. …”
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    Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
  9. 14229
    “…The present study uses a CRISPR/Cas9-based synergistic activation mediator (SAM) system to identify potential lncRNAs capable of regulating AKT activity. …”
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    LncRNA AK023948 is a positive regulator of AKT
  10. 14230
    “…Orthogonal partial least squares discriminant analysis (OPLS-DA), significance analysis of microarray (SAM) and Mann-Whitney U test are used for data analysis. …”
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    A characteristic biosignature for discrimination of gastric cancer from healthy population by high throughput GC-MS analysis
  11. 14231
    “…For instance, methionine (i) is the N-terminal amino acid of every newly translated protein; (ii) acts as the central donor of methyl groups through S-adenosyl methionine (SAM) during methylation reactions of proteins, DNA or RNA; and (iii) provides the sulfhydryl groups for FeS-cluster formation and redox detoxification via transsulfuration to cysteine. …”
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    Autophagy extends lifespan via vacuolar acidification
  12. 14232
    “…Self-assembled monolayers (SAM) of 3-mercaptopropionic acid (MPA) were employed to covalently immobilize the anti-T-Tau (T-Tau antibody) on the gold working electrode. …”
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    A Single-Use, In Vitro Biosensor for the Detection of T-Tau Protein, A Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using Differential Pulse Voltammetry (DPV)
  13. 14233
    “…We prepared DNA self-assembled monolayers (DNA-SAMs) on gold substrates and found that the sequence-specific orientation of DNA-SAMs played an important role in modulating cell adhesion. …”
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    DNA orientation-specific adhesion and patterning of living mammalian cells on self-assembled DNA monolayers
  14. 14234
    “…While these shifts result from an increasing tilt angle from penetration of the SAM by the AFM tip for the latter, we ascribe them to distortions of the π system present in T4C4, which is more mechanically robust than alkanethiolates of comparable length; SAMs comprising T4C4 shows about five times higher Young’s modulus than alkanethiolates. …”
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    Mechanically and Electrically Robust Self-Assembled Monolayers for Large-Area Tunneling Junctions
  15. 14235
    “…The methylation of natural products by S-adenosyl methionine (AdoMet, also known as SAM)-dependent methyltransferase enzymes is a common tailoring step in many biosynthetic pathways. …”
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    Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase
  16. 14236
    “…We compared significant genotype-specific GO-BP term results for overlap and rank order across three replicate pairs per genotype, and cross-methods to reference standards (limma+FET, SAM+FET, and GSEA). All single-subject analytics findings were robust and highly reproducible (median area under the ROC curve=0.96, n=24 genotypes × 3 replicates), providing confidence and validation of this approach for analyses in single subjects. …”
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    Single subject transcriptome analysis to identify functionally signed gene set or pathway activity
  17. 14237
    “…By characterizing the PA2444 enzyme in vitro, we determined the physiological function of PA2444 protein by relating it to S-adenosylmethionine (SAM) concentrations and methylation of a membrane bound methyl-accepting chemotaxis protein WspA. …”
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    Serine Hydroxymethyltransferase ShrA (PA2444) Controls Rugose Small-Colony Variant Formation in Pseudomonas aeruginosa
  18. 14238
    por Li, Long, Zhou, Xiaoxiao
    Publicado 2018
    “…The proposed method paves a reconfigurable way to generate multiple OAM vortex waves with spin angular momentum (SAM) in radio and microwave satellite communication applications.…”
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    Mechanically Reconfigurable Single-Arm Spiral Antenna Array for Generation of Broadband Circularly Polarized Orbital Angular Momentum Vortex Waves
  19. 14239
    “…The methods of nasal absorption (NA) and bronchial absorption (BA) use synthetic absorptive matrices (SAM) to absorb the mucosal lining fluid (MLF) of the human respiratory tract. …”
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    Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
  20. 14240
    por Sun, Anqi, Ban, Zhan, Mu, Li, Hu, Xiangang
    Publicado 2018
    “…A metabolomics analysis of cells exposed to nanosilver (nAg) integrates volcano plots (t‐tests and fold change analysis), partial least squares‐discriminant analysis (PLS‐DA), and significance analysis of microarrays (SAM) and identifies six metabolites (l‐aspartic acid, l‐malic acid, myoinositol, d‐sorbitol, citric acid, and l‐cysteine). …”
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    Screening Small Metabolites from Cells as Multifunctional Coatings Simultaneously Improves Nanomaterial Biocompatibility and Functionality
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