“…Several families of transcription factors (AP2/ERF, NAC, and MADS-box) were differentially expressed. ACO, ACS, and SAM-Mtase genes were upregulated, indicating a high rate of ethylene biosynthesis after ethylene treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The docking of seven million commercially available drug-like compounds and S-adenosylmethionine (SAM) co-substrate analogues against both MTases resulted in 80 virtual screening hits (39 against nsp14 and 41 against nsp16), which were purchased and tested using an enzymatic homogeneous time-resolved fluorescent energy transfer (HTRF) assay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…AMs derive from existing stem cell lineages that exit from SAMs and define new growth axes. AMs are in fact additional rounds of SAMs, and display the same expression patterns and functions as the embryonic SAM, creating a fractal branching pattern. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…GUS staining results showed that LtuJAG was expressed in the shoot apical meristem (SAM). Overexpressing LtuJAG changed A. thaliana leaf shapes, causing a moderate serration and a slight asymmetric distribution in the medio-lateral and proximal-distal axes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We further collected fetal mice brains for metabolome analysis and found that in GDM fetal brains, the metabolites displayed significant changes, in addition to directly inducing cognitive dysfunction, some of which are important to methylation status such as betaine, fumaric acid, L-methionine, succinic acid, 5-methyltetrahydrofolic acid, and S-adenosylmethionine (SAM). These results suggest that GDM affects metabolites in fetal mice brains and further affects hippocampal DNA methylation and gene regulation involved in cognition, which is a potential mechanism for the adverse neurocognitive effects of GDM in offspring.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among the various epigenetic changes, DNA methylation is directly linked to oxidative stress metabolism via critical redox intermediates such as NAD+, S-adenosylmethionine (SAM), and 2-oxoglutarate. Fluctuations in these intermediates directly influence epigenetic signatures, which leads to detectable alterations in gene expression and protein modification. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, GAMT-loaded RBCs were ineffective in GAA consumption and creatine production because of the limiting intra-erythrocytic S-adenosyl methionine (SAM) content unable to support GAMT activity. Therefore, a recombinant form of human methionine adenosyl transferase (MAT) was developed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we identify a radical SAM protein, tetraether synthase (Tes), that participates in the synthesis of GDGTs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These appended amino acids are further sculpted by various enzyme classes such as radical SAM isomerases, PLP-dependent decarboxylases, flavin-dependent lyases and acetyltransferases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additionally, we formulate the robust optimisation problem using standard Gaussian factors so that it can be solved by direct application of popular incremental estimation approaches such as iSAM. Experimental results on publicly available synthetic datasets and real LiDAR-SLAM datasets collected from the 2D and 3D LiDAR systems show the competitiveness of our approach with the state-of-the-art techniques and its superiority on real world scenarios.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, we showed that molecules regulating Dnmts activity were altered; specifically, SAM/SAH ratio reduction. All these results are in concordance with the Dnmts normal function that we show. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In an attempt to protect these nanostructures against NaCl, we modified them with alkanethiols with different lengths in the vapor phase and found that shorter chain alkanethiols such as 1-butanethiol are particularly effective against even 250 mM NaCl, rather than longer-chain alkanethiols more suitable for robust SAM formation. A vapor phase treatment method, in contrast to widely used solution phase treatment methods, was selected with the intention of reducing the solvent effect, i.e. destruction of intricate nanostructures upon contact with a solvent when nanostructures have been prepared in a vacuum system. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…DC_05 and DC_517 have been reported in our previous work, which is non-nucleoside DNMT1 inhibitor with low micromolar IC(50) values and significant selectivity towards other S-adenosyl-(L)-methionine (SAM)-dependent protein methyltransferases. In this study, through a process of similarity-based analog searching, a series of DNMT1 inhibitors were designed, synthesized, and evaluated as anticancer agents. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The analysis is developed through the application of a SAM based CGE and the results are provided in terms of change in production, final demand and disposable income.…”
Enlace del recurso
Enlace del recurso

“…Our prior work revealed that the sterile alpha motif (SAM) domain 14 (Samd14) gene increases the regenerative capacity of the erythroid system in a mouse genetic model and promotes stress-dependent Kit signaling. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In combination with data mining, statistical and metabolic pathway analyses suggest increased S-adenosyl-L-methionine (SAM) levels and changes of amino acid metabolites as important variables for overfeeding. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…S-adenosylmethionine synthetase (SAMS) is a key enzyme for the synthesis of the lone methyl donor S-adenosyl methionine (SAM), which is involved in transmethylation reactions and hence required for cellular processes such as DNA, RNA, and histone methylation, but also polyamine biosynthesis and proteostasis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] Taking advantage of the uniquely constricted active site of SARS-CoV-2 Nsp14 methyltransferase, we have designed bisubstrate inhibitors interacting with the SAM and RNA substrate binding pockets. Our efforts have led to nanomolar inhibitors including compounds 3 and 10. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The interparticle distance between AuNPs was tuned by selecting mercaptocarboxylic acids of various carbon chain lengths when each acid forms a mixed SAM with 2-MOTP. The SERS signal quantification was accomplished by combining maps of SERS intensity from a Raman microscope, optical microscope images (×100), and maps/images from AFM or SEM. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso