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14621“…However, the healthy controls held higher gut metabolic modules (GMMs) including glycolysis, homoacetogenesis, and GBMs including quinolinic acid degradation and S-adenosyl methionine (SAM) synthesis. The differences in gut microbiota composition and function between the migraine and healthy groups provided new information as well as novel therapeutic targets and strategies for migraine treatment, which could help to improve the early diagnosis of the disease, as well as the long-term prognosis and the life quality of patients suffering from migraine.…”
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14622por Meyer, Britta, Immer, Carina, Kaiser, Steffen, Sharma, Sunny, Yang, Jun, Watzinger, Peter, Weiß, Lena, Kotter, Annika, Helm, Mark, Seitz, Hans-Michael, Kötter, Peter, Kellner, Stefanie, Entian, Karl-Dieter, Wöhnert, Jens“…Here we identify the so far functionally uncharacterized YfiP protein as the SAM-dependent 3-amino-3-carboxypropyl transferase catalyzing this modification and thereby extend the list of known tRNA modification enzymes in E. coli. …”
Publicado 2020
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14623por Lu, Mengjiang, He, Yan, Gong, Meirong, Li, Qian, Tang, Qianqian, Wang, Xuan, Wang, Yaling, Yuan, Mengqian, Yu, Zhi, Xu, Bin“…Compared to HFD rats, EA can decrease sympathetic associated macrophage (SAM) and the level of norepinephrine transporter protein (Slc6a2). …”
Publicado 2020
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14624“…Homocysteine biosynthesis from methionine forms S-adenosyl methionine (SAM), which is a major methyl donor critical in DNA methylation. …”
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14625por Matthews, Graham J.“…In the face of continuing post-war reconstruction and the rising tide of urbanization, British science fiction writers such as John Wyndham (a pseudonym for John Beynon Harris) and John Christopher (Sam Youd) portrayed post-apocalyptic scenarios in which the vegetal directly determines the fate of human civilization. …”
Publicado 2016
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14626por Rettberg, Lee A., Wilcoxen, Jarett, Jasniewski, Andrew J., Lee, Chi Chung, Tanifuji, Kazuki, Hu, Yilin, Britt, R. David, Ribbe, Markus W.“…NifB is a radical S-adenosyl-L-methionine (SAM) enzyme that is essential for nitrogenase cofactor assembly. …”
Publicado 2020
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14627por Finnegan, Alex I, Kim, Somang, Jin, Hu, Gapinske, Michael, Woods, Wendy S, Perez-Pinera, Pablo, Song, Jun S“…Time-course expression measurements captured dynamic network-level adaptation of cells to DNMT3B1-induced DNA methylation stress and showed that coordinately modulating the availability of S-adenosyl methionine (SAM), the essential metabolite for DNMT-catalyzed methylation, is an evolutionarily conserved epigenetic stress response, also implicated in several human diseases. …”
Publicado 2020
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14628por Bajkowska, Karolina, Sumardika, I. Wayan, Tomonobu, Nahoko, Chen, Youyi, Yamamoto, Ken-ichi, Kinoshita, Rie, Murata, Hitoshi, Gede Yoni Komalasari, Ni Luh, Jiang, Fan, Yamauchi, Akira, Winarsa Ruma, I. Made, Kasano-Camones, Carlos Ichiro, Inoue, Yusuke, Sakaguchi, Masakiyo“…The molecular mechanism of the signal pathway downstream of NPTNβ is a serial activation of the key molecules we identified: tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) adaptor, nuclear factor (NF)IA/NFIB heterodimer transcription factor, and SAM pointed-domain containing ETS transcription factor (SPDEF). …”
Publicado 2020
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14629por Kim, Sunho, Mun, Chaewon, Choi, Dae-Geun, Jung, Ho Sang, Kim, Dong-Ho, Kim, Shin-Hyun, Park, Sung-Gyu“…A self-assembled monolayer (SAM) of perfluorodecanethiol (PFDT) was coated on the Au surface, on which Au was further deposited. …”
Publicado 2020
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14630por Gabardo, Marilisa Carneiro Leão, Kublitski, Prescila Mota de Oliveira, Sette, Isabela Rodrigues, Lauschner, Thaís, Juglair, Mariana Martins, Baratto-Filho, Flares, Brancher, João Armando, Michel-Crosato, Edgard“…The organic components, such as urea (URE), glucose (GLU), total proteins (TPTs), alkaline phosphatase, creatinine (CRE), salivary amylase (SAM), and uric acid (URA), and the inorganic components, such as calcium, iron, and phosphorus, were evaluated by colorimetric techniques in an ultraviolet–visible (UV–vis) spectrophotometer. …”
Publicado 2020
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14631“…The occurrence of siltation is confirmed by the detection of minerals using the VNIR-SWIR bands by the Spectral Angle Mapper (SAM) method. In addition, the siltation of the dam is studied for the years 1987 to 2018 using Landsat satellite images. …”
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14632por Freisleben, Fabian, Behrmann, Lena, Thaden, Vanessa, Muschhammer, Jana, Bokemeyer, Carsten, Fiedler, Walter, Wellbrock, Jasmin“…Knockdown of GLI3 resulted in the upregulation of SAM and HD domain-containing protein 1 (SAMHD1), cytidine deaminase (CDA), and ATP-binding cassette C11 (ABCC11)/multidrug resistance-associated protein 8 (MRP8), each of which has been identified as a predictive marker for Ara-C response in acute myeloid leukemia. …”
Publicado 2020
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14633por Hyeon, Seokhwan, Lee, Myoung Kyu, Kim, Young-Eui, Lee, Gwang Myeong, Ahn, Jin-Hyun“…Sterile alpha motif (SAM) and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) acts as a restriction factor for several RNA and DNA viruses by limiting the intracellular pool of deoxynucleoside triphosphates. …”
Publicado 2020
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14634por Bian, Yingjie, Li, Wei, Kremer, Daniel M., Sajjakulnukit, Peter, Li, Shasha, Crespo, Joel, Nwosu, Zeribe C., Zhang, Li, Czerwonka, Arkadiusz, Pawłowska, Anna, Xia, Houjun, Li, Jing, Liao, Peng, Yu, Jiali, Vatan, Linda, Szeliga, Wojciech, Wei, Shuang, Grove, Sara, Liu, J. Rebecca, McLean, Karen, Cieslik, Marcin, Chinnaiyan, Arul M., Zgodziński, Witold, Wallner, Grzegorz, Wertel, Iwona, Okła, Karolina, Kryczek, Ilona, Lyssiotis, Costas A., Zou, Weiping“…Here, we show that tumor cells disrupt methionine metabolism in CD8(+) T cells, thereby lowering intracellular methionine levels and the methyl donor S-adenosylmethionine (SAM), resulting in loss of H3K79me2. Consequently, loss of H3K79me2 led to low STAT5 expression and impaired T cell immunity. …”
Publicado 2020
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14635por Pignataro, Marcello, Rocco, Giulia Di, Lancellotti, Lidia, Bernini, Fabrizio, Subramanian, Khaushik, Castellini, Elena, Bortolotti, Carlo Augusto, Malferrari, Daniele, Moro, Daniele, Valdrè, Giovanni, Borsari, Marco, Monte, Federica del“…For this purpose, CV measurements were carried out on human cofilin-2 WT and its mutant S3D immobilized on a gold electrode coated by an anionic self-assembled monolayer (SAM), after a pre-oxidation time which was fundamental for observing a CV signal relating to the oxidation/reduction process of the disulfide bridge of the proteins. …”
Publicado 2020
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14636por Arsović, Aleksandar, Halbach, Melanie Vanessa, Canet-Pons, Júlia, Esen-Sehir, Dilhan, Döring, Claudia, Freudenberg, Florian, Czechowska, Nicoletta, Seidel, Kay, Baader, Stephan L., Gispert, Suzana, Sen, Nesli-Ece, Auburger, Georg“…The earliest changes were detected at three months among Ca(2+) channels/transporters (Itpr1, Ryr3, Atp2a2, Atp2a3, Trpc3), IP(3) metabolism (Plcg1, Inpp5a, Itpka), and Ca(2+)-Calmodulin dependent kinases (Camk2a, Camk4). CaMKIV–Sam68 control over alternative splicing of Nrxn1, an adhesion component of glutamatergic synapses between granule and Purkinje neurons, was found to be affected. …”
Publicado 2020
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14637por Wang, Xintai, Bennett, Troy L. R., Ismael, Ali, Wilkinson, Luke A., Hamill, Joseph, White, Andrew J. P., Grace, Iain M., Kolosov, Oleg V., Albrecht, Tim, Robinson, Benjamin J., Long, Nicholas J., Cohen, Lesley F., Lambert, Colin J.“…Recently, the effect of destructive QI (DQI) on the electrical conductance of self-assembled monolayers (SAMs) has been investigated. Here, through a combined experimental and theoretical investigation, we demonstrate chemical control of different forms of constructive QI (CQI) in cross-plane transport through SAMs and assess its influence on cross-plane thermoelectricity in SAMs. …”
Publicado 2020
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14638por Burgess, Joshua T., Bolderson, Emma, Adams, Mark N., Duijf, Pascal H. G., Zhang, Shu-Dong, Gray, Steven G., Wright, Gavin, Richard, Derek J., O’Byrne, Kenneth J.“…SASH1 (SAM and SH3 domain-containing protein 1) is a tumor suppressor protein that has roles in key cellular processes including apoptosis and cellular proliferation. …”
Publicado 2020
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14639“…Barratt Impulsiveness Scale (BIS), Decision-Making Style Scale (DMSQ), Manchester Driver Behavior Questionnaire (MDBQ), Self-Assessment Manikin Scale (SAM), and Dot Probe Task were used. The analyses were performed using IBM SPSS version 22. …”
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14640“…Principal component analysis reveals that such a bi-polar pattern is likely modulated by the Southern Annular Mode (SAM). We also find that recent ice mass loss acceleration in 2007 is related to a variation in precipitation accumulation. …”
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