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  1. 381
    “…The TRPC channel inhibitors SKF96365 and flufenamic acid significantly inhibited the [Ca(2+)](i) spikes in the absence or presence of DHPG. …”
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    Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca(2+)-spikes and cell death in cultured rat hippocampal neurons
  2. 382
    “…Better outcomes for HT were found in IKDC-SKF, the KOOS, donor site morbidity, pivot shift test, radiographic osteoarthritis (IKDC C or D) and contralateral ACL rupture. …”
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    Long-term results after anterior cruciate ligament reconstruction using patellar tendon versus hamstring tendon autograft with a minimum follow-up of 10 years—a systematic review
  3. 383
    “…Following acute administration of cocaine (15 mg/kg, i.p.) or D1 agonist (SKF 82958; 1 mg/kg, i.p.) there were significantly higher levels of Ser133 P-CREB, Thr34 P-DARPP-32, and Thr202/Tyr204 P-ERK2 in the Str that were evident in all animals tested. …”
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    Enhanced Dopamine D1 and BDNF Signaling in the Adult Dorsal Striatum but not Nucleus Accumbens of Prenatal Cocaine Treated Mice
  4. 384
    “…To characterize the stimulation of cAMP through the dopamine D(1) receptor, HASM cells were treated with dopamine or the dopamine D(1)-like receptor agonists (A68930 or SKF38393) before cAMP measurements. To evaluate whether the activation of dopamine D(1) receptor induces ASM relaxation, guinea pig tracheal rings suspended under isometric tension in organ baths were treated with cumulatively increasing concentrations of dopamine or A68930, following an acetylcholine-induced contraction with or without the cAMP-dependent protein kinase (PKA) inhibitor Rp-cAMPS, the large-conductance calcium-activated potassium (BK(Ca)) channel blocker iberiotoxin, or the exchange proteins directly activated by cAMP (Epac) antagonist NSC45576. …”
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    The dopamine D(1) receptor is expressed and facilitates relaxation in airway smooth muscle
  5. 385
    “…In addtion, the TSK-J was significantly but moderately correlated with the IKDC-SKF (r = − 0.49, P <0.001), VAS-Sports (r = − 0.48, P <0.001), and JACL-25 (r = 0.48, P <0.001). …”
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    Reproducibility, responsiveness and validation of the Tampa Scale for Kinesiophobia in patients with ACL injuries
  6. 386
    “…We use DMT myography pressure-diameter system to investigate biomechanical properties of carotid arteries, 10 μM pan-classical transient receptor potential channels (TRPCs) inhibitor SKF96365, 200 nM specific TRPC6 inhibitor SAR7334 and 100 μM Orai1 inhibitor ANCOA4 were used in the mechanical test. …”
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    Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats
  7. 387
    “…The phosphorylation levels of ERK1/2, S6K1, and 4E-BP1 in 6-OHDA-lesioned striatum were increased by L-dopa or D1 receptor agonist SKF38393 (p < 0.05, respectively), not by the combination of L-dopa and D1 receptor antagonist SCH23390, which was similar to the expressions of BMAL1 and CLOCK. …”
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    L-3,4-Dihydroxyphenylalanine Recovers Circadian Rhythm Disturbances in the Rat Models of Parkinson's Disease by Regulating the D1R-ERK1/2-mTOR Pathway
  8. 388
    “…The comparative experiments demonstrate that LPI-EnEDT outperforms four classical LPI prediction methods (LPI-BLS, LPI-CatBoost, LPI-SKF, and PLIPCOM) under cross validations on lncRNAs, proteins, and LPIs. …”
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    LPI-EnEDT: an ensemble framework with extra tree and decision tree classifiers for imbalanced lncRNA-protein interaction data classification
  9. 389
    “…Furthermore, TRPC6 agonist (OGA) or TRPC6 inhibitor (SKF96365) were introduced to increase or inhibit the activity of TRPC6 in RIRI model rats, and the kidney injury was assessed with H&E staining and RIP1 and PARP-1 expressions were examined with IHC (immunohistochemistry) staining. …”
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    TRPC6 ameliorates renal ischemic reperfusion injury by inducing Zn(2+) influx and activating autophagy to resist necrosis
  10. 390
    “…To further demonstrate the role of DRD1 and DRD2 in the BLA in spared nerve injury (SNI) model-induced anxiety-like behaviors, we injected the DRD1 agonist SKF38393 or the DRD2 antagonist sulpiride into the BLA. …”
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    Electroacupuncture Alleviates Anxiety-Like Behaviors Induced by Chronic Neuropathic Pain via Regulating Different Dopamine Receptors of the Basolateral Amygdala
  11. 391
    “…Phosphorylation of cAMP-dependent protein kinase (PKA) substrates (GluA1, ERK2, DARPP-32, PDE4) was increased and showed higher sensitivity to SKF81297, a Drd1-like agonist, in Cn mutants than in controls. …”
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    Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice
  12. 392
    “…In L-NAME-treated hearts, 5-HT-induced coronary flow increases were blocked by the phospholipase A(2) inhibitor quinacrine and the cytochrome P450 inhibitor SKF525A, but were not inhibited by the cyclooxygenase inhibitor indomethacin. …”
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    5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts
  13. 393
    “…In addition, the promoting effect of ESI-09 on ASMCs proliferation was inhibited by store-operated Ca(2+) channel blocker, SKF-96365. CONCLUSIONS: Our results suggest that Epac has a protecting effect on asthmatic airway inflammation and airway remodeling, and Epac reduces ASMCs proliferation by inhibiting SOCE in part.…”
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    Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice
  14. 394
    “…METHODS: G-protein receptor coupling was assessed in control caudate nucleus and frontal cortex by [(35)S]GTPγS-binding stimulation induced by increasing concentrations (10(–10)–10(–3) M) of dopamine, and the selective dopaminergic agonists SKF38393 (D1R) and NPA (D2R). Concentration–response curves to NPA stimulation of [(35)S]GTPγS binding were analyzed in antipsychotic-free (n = 10) and antipsychotic-treated (n = 7) schizophrenia subjects and matched controls (n = 17). …”
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    Characterization of dopamine D(2) receptor coupling to G proteins in postmortem brain of subjects with schizophrenia
  15. 395
    “…Under a slightly confined microenvironment, treatment with the TRPC6 inhibitor SKF96365 and TRPC6 knockout decreased the migration speed of hPDLSCs and mouse bone marrow mesenchymal stem cells (mBMSCs). …”
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    Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress
  16. 396
    “…ACLR outcomes were measured 24 months after surgery and included PROs (International Knee Documentation Committee Subjective Knee Form (IKDC-SKF) and Knee injury and Osteoarthritis Outcome Score (KOOS)) as well as in vivo joint kinematics during downhill running. …”
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    The Effect of Injury to Anterolateral Capsular Structures on Outcomes of ACL Injured Patients 24 Months after Anatomic ACL Reconstruction
  17. 397
    “…To characterize the stimulation of cAMP through the dopamine D(1) receptor, 16HBE14o- cells and NCI-H292 cells were treated with dopamine or the dopamine D(1) receptor agonists (SKF38393 or A68930) before cAMP measurements. The phosphorylation of CREB by A68930 in both 16HBE14o- and NCI-H292 cells was measured by immunoblot. …”
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    The dopamine D(1) receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium
  18. 398
    “…LPI-deepGBDT is compared with five classical LPI prediction models (LPI-BLS, LPI-CatBoost, PLIPCOM, LPI-SKF, and LPI-HNM) under three cross validations on lncRNAs, proteins, lncRNA–protein pairs, respectively. …”
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    LPI-deepGBDT: a multiple-layer deep framework based on gradient boosting decision trees for lncRNA–protein interaction identification
  19. 399
    “…LPI-HyADBS is compared to six classical LPI prediction approaches (LPI-SKF, LPI-NRLMF, Capsule-LPI, LPI-CNNCP, LPLNP, and LPBNI) on five datasets under 5-fold cross validations on lncRNAs, proteins, lncRNA-protein pairs, and independent lncRNAs and independent proteins. …”
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    LPI-HyADBS: a hybrid framework for lncRNA-protein interaction prediction integrating feature selection and classification
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