“…Activation of D(1)-like class of DA receptors by the D(1)-receptor selective agonist SKF-81297 (SKF) enhances whole-cell Ca(2+) currents through Ca(V)1 channels modulation. …”
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“…TRPV2 silencing or pharmacological targeting by Tranilast (TL) or SKF96365 (SKF) triggered caspace-mediated apoptosis and cell cycle arrest. …”
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“…Application of a D(1)R agonist, SKF-38393, shifted the peak temporal responses toward higher frequencies in a subset of bipolar cells. …”
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“…HYP9 (a selective TRPC6 agonist) and SKF96365 (SKF; a TRPC antagonist) were used to clarify the exact functions of TRPC6 in astrocytes after ischemic stroke. …”
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“…Among the control groups that received saline or SKF-83566, the time spent in the two conditioning chambers was not significantly altered. …”
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“…The activity of mixed function oxidases (MFO), the drug-metabolizing system of the endoplasmic reticulum, could be suppressed in these cells by SKF525A or stimulated by NADPH. SKF525A caused a reduction in the inhibition by aflatoxin B1 of the incorporation of RNA precursor into macromolecules. …”
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“…In contrast, zaprinast caused only a weak inhibition (IC(50) = 119 μM) of lymphocyte proliferation, whereas SKF 94836 and theophylline failed to cause any significant inhibition at 100 μM (26% and 2%, respectively). …”
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“…Tolerance was recorded in the presence of GABA(B) drugs, but the rate of tolerance development was increased by SKF 97451 and unaltered in presence of CGP 54626. …”
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“…RESULTS: Significant differences were found among the RTS≥Pre, RTS<Pre, and no-RTS groups in age, ACL-RSI score at 6 and 12 months, quadriceps strength at 6 and 12 months, and IKDC-SKF score at 6 and 12 months (P < .001 for all). …”
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“…RESULTS: SHR rats were more behaviourally active than WKY rats after injection with vehicle. The 0.3 mg/kg dose of SKF-81297 increased motor behaviour (locomotion, sifting, rearing, and sniffing) in both SHR and WKY rats. …”
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“…The release was blocked by SKF96365 (20 μM) and BAPTA-AM (0.05 or 0.1 mM). …”
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“…Pretreatment with two inhibitors of SOC, SKF96365 or gadolinium, was used to examine for effects on [Ca(2+)]i. …”
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“…RESULTS: Here we demonstrated that DL-AP3, a Grp1 mGluR antagonist, rescued LTP facilitation by D1 receptor agonist SKF81297 in Fmr1KO mice. Grp1 mGluR inhibition restored the GluR1-subtype AMPA receptors surface insertion by D1 activation in the cultured Fmr1KO neurons. …”
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“…Moreover, the v-DG injection of SKF38393 in MPTP-mice could reduce the loss of D21-BrdU(+) cells and relieve the depressive-like behaviors. …”
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“…The selective D1-like receptor agonist SKF81297 also had modulatory effects on the majority of VP neurons, but its effects were universally excitatory. …”
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“…In spinal cord preparations from postnatal mice, a D(1)LR agonist, SKF 38393, increased the frequency of locomotor-related bursting induced by 5-hydroxytryptamine and N-methyl-d-aspartate. …”
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“…RESULTS: High concentration Epi and two dopamine D1/D5 receptor agonists [(±)-SKF 38393 and fenoldopam] reduced the depolarization velocity and prolonged the duration of action potentials (APs) and caused arrhythmic events in iPSC-CMs, suggesting involvement of dopamine D1/D5 receptor signaling in arrhythmogenesis associated with QT interval prolongation in the setting of TTC. (±)-SKF 38393 and fenoldopam enhanced the reactive oxygen species (ROS)-production. …”
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“…The latter phase of the [Ca(2+)](i )increase was blocked by SKF96365, a non-selective store-operated channel (SOC) inhibitor. …”
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“…Aminobenzotriazole provided protection from DDM-induced hepatotoxicity, whereas SKF-525A had no effect. The effect of phenobarbital pretreatment depended on the dose of DDM administered. …”
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“…SKF-86466 also rescues IKAP protein expression and the disease-specific loss of autonomic neuron marker expression. …”
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