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241por Thomas, Stacey L., Schultz, Chad R., Mouzon, Ezekiell, Golembieski, William A., Naili, Reima El, Radakrishnan, Archanna, Lemke, Nancy, Poisson, Laila M., Gutiérrez, Jorge A., Cottingham, Sandra, Rempel, Sandra A.“…Both the induction of SPARC expression and the loss of the p53 tumor suppressor gene are changes that occur early in glioma development. …”
Publicado 2015
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242por Bruening, Meg, van Woerden, Irene, Todd, Michael, Brennhofer, Stephanie, Laska, Melissa N, Dunton, Genevieve“…An mEMA app, devilSPARC, was developed to assess weight-related behaviors in real time. …”
Publicado 2016
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243por Holyoake, Daniel L. P., Ward, Elizabeth, Grose, Derek, McIntosh, David, Sebag-Montefiore, David, Radhakrishna, Ganesh, Patel, Neel, Silva, Michael, Mukherjee, Somnath, Strauss, Victoria Y., Odondi, Lang’o, Fokas, Emmanouil, Melcher, Alan, Hawkins, Maria A.“…Stereotactic radiotherapy achieves sufficient accuracy and precision to enable pre-operative margin-intensive dose escalation with the goal of increasing rates of clear resection margins and local disease control. METHODS/DESIGN: SPARC is a “rolling-six” design single-arm study to establish the maximum tolerated dose for margin-intensive stereotactic radiotherapy before resection of pancreatic cancer at high risk of positive resection margins. …”
Publicado 2016
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244por Al-Dabbagh, Najwa, Al-Shahrani, Hamoud, Al-Dohayan, Nourah, Mustafa, Md, Arfin, Misbahul, Al-Asmari, Abdulrahman K“…Secreted protein acidic and rich in cysteine (SPARC)-related modular calcium binding protein 2 (SMOC2) is a matricellular glycoprotein encoded by the SMOC2 gene and known to regulate the expression of extracellular matrix (ECM) proteins and matrix metalloproteinases (MMPs), which play an important role in the pathogenesis of primary glaucomas. …”
Publicado 2017
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245“…This solution is validated with an accompanying interactive web application (bit.ly/loadsparcs) capable of real-time traversal of New York’s 20 million patient records of the Statewide Planning and Research Cooperative System (SPARCS), and is compared with alternative approaches. …”
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246por Li, Li, Zhu, Zuan, Zhao, Yanchao, Zhang, Qi, Wu, Xiaoting, Miao, Bei, Cao, Jiang, Fei, Sujuan“…Survival analysis based on the TCGA database found that the expression of the FN1, SERPINE1, and SPARC significantly predicted poor prognosis of GAC. …”
Publicado 2019
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247por Liu, Yao, Feng, Ying, Wang, Xiaojing, Yang, Xue, Hu, Ying, Li, Yuxin, Zhang, Qun, Huang, Yunyi, Shi, Ke, Ran, Chongping, Hou, Jie, Jiang, Li, Li, Junfa, Wang, Xianbo“…Lentiviral vectors carrying interference sequences, as well as vectors harboring the complete open reading frame of SPARC for the knockdown or overexpression of SPARC in HuH-7 or HepG2 cells, respectively, allowed us to determine the biological functions of SPARC in vitro and in vivo. …”
Publicado 2020
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248por Akutsu, Taisuke, Ito, Eisaku, Narita, Mitsuo, Ohdaira, Hironori, Suzuki, Yutaka, Urashima, Mitsuyoshi“…It has been suggested that secreted protein acidic and rich in cysteine (SPARC), one of the myokines that is secreted into the bloodstream by muscle contraction, has tumor-suppressive effects. …”
Publicado 2020
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249por Chun, Yong Yao, Yap, Zhu Li, Seet, Li Fong, Chan, Hiok Hong, Toh, Li Zhen, Chu, Stephanie W. L., Lee, Ying Shi, Wong, Tina T., Tan, Timothy T. Y.“…Through in vitro studies using mouse tenon fibroblasts, the positive-charge tuned Gtn-Tyr hydrogel shows sustained siSPARC cellular internalization and effective SPARC silencing with excellent biocompatibility. …”
Publicado 2021
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250por Suvaal, Isabelle, Hummel, Susanna B., Mens, Jan-Willem M., van Doorn, Helena C., van den Hout, Wilbert B., Creutzberg, Carien L., ter Kuile, Moniek M.“…METHODS/DESIGN: The intervention is evaluated in the SPARC (Sexual rehabilitation Programme After Radiotherapy for gynaecological Cancer) study, a multicentre, randomized controlled trial (RCT). …”
Publicado 2021
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251por Wang, Yaqing, Gu, Jia, Du, Anning, Zhang, Siqi, Deng, Mengqing, Zhao, Rong, Lu, Yan, Ji, Yue, Shao, Yongfeng, Sun, Wei, Kong, Xiangqing“…Secreted protein acidic and rich in cysteine (SPARC)-related modular calcium binding 1 (SMOC1) is a regulator of BMP2 signalling, but the role of SMOC1 in aortic valve calcification under different conditions has not been studied. …”
Publicado 2021
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253por Jang, Hye Jung, Song, Myung Geun, Park, Cho Rong, Youn, Hyewon, Lee, Yun-Sang, Cheon, Gi Jeong, Kang, Keon Wook“…Here, we visualized the SPARC-dependent uptake of ICG and ICG-HSA complex in U87MG. …”
Publicado 2023
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254por Alesini, D., Boni, R., Di Pirro, G., Di Raddo, R., Ferrario, M., Gallo, A., Lollo, V., Marcellini, F., Higo, T., Kakihara, K., Matsumoto, S., Campogiani, G., Mostacci, A., Palumbo, L., Persichelli, S., Spizzo, V., Verdú-Andrés, S.Materias: Enlace del recurso
Publicado 2011
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255por Alcaraz, Lindsay B., Mallavialle, Aude, Mollevi, Caroline, Boissière‐Michot, Florence, Mansouri, Hanane, Simony‐Lafontaine, Joelle, Laurent‐Matha, Valérie, Chardès, Thierry, Jacot, William, Turtoi, Andrei, Roger, Pascal, Guiu, Séverine, Liaudet‐Coopman, Emmanuelle“…The current mechanistic evidence from cell‐based studies suggests that the matricellular protein SPARC has a tumor‐promoting role in TNBC; however, data on the clinical relevance of SPARC expression/secretion by tumor and stromal cells in TNBC are limited. …”
Publicado 2022
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256“…This paper highlights how SPARC could be of such therapeutic use.…”
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257por Onorato, Agostina M., Lameroli Mauriz, Lucía, Bayo, Juan, Fiore, Esteban, Cantero, María José, Bueloni, Barbara, García, Mariana, Lagües, Cecilia, Martínez-Duartez, Pedro, Menaldi, Gabriel, Paleari, Nicolas, Atorrasagasti, Catalina, Mazzolini, Guillermo D.“…In vitro studies were conducted in a macrophage cell line and primary hepatocyte cultures to assess the effect of SPARC on inflammasome. A NAFLD model was established in SPARC knockout (SPARC(−/−)) and SPARC(+/+) mice to explore inflammasome activation. …”
Publicado 2023
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258Publicado 1989“…The activity of native SPARC was inhibited by heat denaturation and prior incubation with anti-SPARC IgG. …”
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259por Xu, Yong Zhong, Heravi, Mitra, Thuraisingam, Thusanth, Marco, Sergio Di, Muanza, Thierry, Radzioch, Danuta“…BACKGROUND: Secreted protein, acidic and rich in cysteine (SPARC) is a matricellular protein that mediates cell-matrix interactions. …”
Publicado 2010
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260por Fenouille, Nina, Tichet, Mélanie, Dufies, Maeva, Pottier, Anaïs, Mogha, Ariane, Soo, Julia K., Rocchi, Stéphane, Mallavialle, Aude, Galibert, Marie-Dominique, Khammari, Amir, Lacour, Jean-Philippe, Ballotti, Robert, Deckert, Marcel, Tartare-Deckert, Sophie“…Ectopic expression or knockdown of SPARC resulted in increased or reduced expression of SLUG, respectively. …”
Publicado 2012
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