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301por Ammer‐Herrmenau, Christoph, Wolf, Laurin, Nasrin, Syeda S., Ramu, Iswarya, Roggiolani, Roberta, Goetze, Robert G., Buchholz, Soeren M., Sendler, Mathias, Ellenrieder, Volker, Neesse, Albrecht“…OBJECTIVE: To investigate the role of secreted protein acidic and rich in cysteine (SPARC) during cerulein‐induced AP in mice. METHODS: AP was induced by repeated cerulein injections in SPARC knock‐out mice (SPARC(−/−)) and control littermates (SPARC(+/+)). …”
Publicado 2022
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302por Nakajima, Masao, Yoshino, Shigefumi, Kanekiyo, Shinsuke, Maeda, Noriko, Sakamoto, Kazuhiko, Tsunedomi, Ryoichi, Suzuki, Nobuaki, Takeda, Shigeru, Yamamoto, Shigeru, Hazama, Shoichi, Hoshii, Yoshinobu, Oga, Atsunori, Itoh, Hiroshi, Ueno, Tomio, Nagano, Hiroaki“…Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix glycoprotein that may serve an important role in epithelial-mesenchymal transition. …”
Publicado 2018
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303por Szynglarewicz, Bartlomiej, Kasprzak, Piotr, Donizy, Piotr, Biecek, Przemyslaw, Halon, Agnieszka, Matkowski, Rafal“…Significance of Snail1 and SPARC persisted in multivariate analysis, but the impact of SPARC on invasion was more significant. …”
Publicado 2018
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304por Kao, Steven C, Kirschner, Michaela B, Cooper, Wendy A, Tran, Thang, Burgers, Sjaak, Wright, Casey, Korse, Tiny, van den Broek, Daan, Edelman, James, Vallely, Michael, McCaughan, Brian, Pavlakis, Nick, Clarke, Stephen, Molloy, Mark P, van Zandwijk, Nico, Reid, Glen“…To determine the source of the circulating SPARC, we investigated SPARC expression in MPM tumours and healthy controls, as well as the expression and secretion from cell lines and xenografts. …”
Publicado 2016
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305por Park, Cho Rong, Kim, Hyo Young, Song, Myung Geun, Lee, Yun-Sang, Youn, Hyewon, Chung, June-Key, Cheon, Gi Jeong, Kang, Keon Wook“…To investigate the HSA-dependent therapeutic effect of HSA–CDDP, we used two types of U87MG glioma cells that express SPARC differently. HSA–CDDP was highly taken up in SPARC expressing cells and this uptake was enhanced with exogenous SPARC treatment in cells with low expression of SPARC. …”
Publicado 2020
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306por Xue, Li-Yan, Zou, Shuang-Mei, Zheng, Shan, Liu, Xiu-Yun, Wen, Peng, Yuan, Yan-Ling, Lin, Dong-Mei, Lu, Ning“…Previous studies have shown that the expressions of the γ(2) chain of laminin-5 and secreted protein acidic and rich in cysteine (SPARC) play important roles in oncogenesis and the development of carcinoma. …”
Publicado 2011
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307“…We also demonstrated that internalized SPARC is transported to Rab7-positive endosomes. …”
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308por Ma, Yongchen, Chen, Hongbo, Ma, Huiying, Yao, Zihao, Hu, Jianwen, Ma, Ju, Zhang, Xiaoqian, Chen, Guowei, Liu, Yucun“…Studies that focused on the effects of SPARC expression on solid tumor progression and clinical implications were used. …”
Publicado 2019
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309“…Our results showed that SPARC was highly expressed in MM and the survival rate of the high SPARC expression group was lower than that of the low expression group. …”
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310por Dang, Xuan, Fang, Lanlan, Jia, Qiongqiong, Wu, Ze, Guo, Yanjie, Liu, Boqun, Cheng, Jung-Chien, Sun, Ying-Pu“…Although the regulatory effects of TGF-β1 on SPARC expression have been reported, whether TGF-β1 regulates SPARC expression in the human ovary remains unknown. …”
Publicado 2023
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311“…However, our knowledge of secreted protein acidic and rich in cysteine (SPARC) and its aberrant methylation in gastric cancer (GC) is still inadequate. …”
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312“…Secreted protein acidic and rich in cysteine (SPARC) may play a notable role in aqueous humor outflow through the trabecular meshwork (TM). …”
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313“…METHODS: To this extent, we selected three SPARC full-length cDNA overexpressed clones (Daoy-SP). …”
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314“…The matricellular proteins, secreted protein acidic and rich in cysteine (SPARC) and SPARC-like 1 (SPARCL1), are produced by astrocytes and control excitatory synaptogenesis in the central nervous system. …”
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315por Pinto, Camila, Schuch, Clarissa Pedrini, Balbinot, Gustavo, Salazar, Ana Paula, Hennig, Ewald Max, Kleiner, Ana Francisca Rozin, Pagnussat, Aline Souza“…Previous studies analyzed SPARC in simple walking conditions. However, SPARC outcomes during functional mobility tasks in subjects with PD and freezing of gait (FOG) were never investigated. …”
Publicado 2019
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316por Li, Xiaoqiang, Ding, Xuanfeng, Zheng, Weili, Liu, Gang, Janssens, Guillaume, Souris, Kevin, Barragán-Montero, Ana M., Yan, Di, Stevens, Craig, Kabolizadeh, Peyman“…PURPOSE: To integrate dose-averaged linear energy transfer (LET(d)) into spot-scanning proton arc therapy (SPArc) optimization and to explore its feasibility and potential clinical benefits. …”
Publicado 2021
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317por Luo, Liying, Sun, Xi, Tang, Min, Wu, Jiahui, Qian, Tianwei, Chen, Shimei, Guan, Zhiyuan, Jiang, Yanyun, Fu, Yang, Zheng, Zhi“…Secreted protein acidic and rich in cysteine (SPARC) has been found to play an important role in many diseases, but its role and mechanism in DR remain unknown. …”
Publicado 2022
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318“…Secreted protein acidic and rich in cysteine (SPARC) gene expression is stimulated by exercise and SPARC has been suggested as a molecular mediator of exercise. …”
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319“…This work presents secreted protein acidic and rich in cysteine (SPARC) as a potential antiageing therapy. Indeed, SPARC declines with ageing, exercise induces SPARC, and SPARC overexpression in mice mimics exercise. …”
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320por Kim, Jeong Yeon, Jeong, Dongjun, Ahn, Tae Sung, Kim, Hyung Ju, Park, Doo San, Park, So Yong, Bae, Sang Byung, Lee, Sookyoung, Lee, Sung Soo, Lee, Moon Soo, Cho, Hyun Deuk, Baek, Moo Jun“…In this study, the expression of SPARC was evaluated and its correlations with clinicopathological parameters were investigated. …”
Publicado 2013
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