“…Tenascin, together with thrombospondin and SPARC, form a family of matrix proteins that, when added to bovine aortic endothelial cells, caused a dose-dependent reduction in the number of focal adhesion- positive cells to approximately 50% of albumin-treated controls. …”
Enlace del recurso
Enlace del recurso

“…To address this gap, implementation researchers and clinical leaders at Kaiser Permanente Washington partnered to design a high-quality Program of Sustained Patient-centered Alcohol-related Care (SPARC). Here, we describe the SPARC pilot implementation, evaluate its effectiveness within three large pilot sites, and describe the qualitative findings on barriers and facilitators. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, 24 cases offered samples to assess secreted protein acidic and rich in cysteine (SPARC) expression. No statistical difference was observed in treatment efficacy between SPARC expression-negative and positive. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SPARC-related modular calcium binding 1 (SMOC1) represents a vital member of the SPARC matricellular protein family that regulates cell matrix interaction through binding to cell-surface receptors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Myokines were analysed by ELISA (i.e. BDNF/Fractalkine/SPARC/Irisin/FGF21/Musclin/IL-6). RESULTS: At baseline, Musclin (LRT: 84 ± 24 vs HRT: 26 ± 3 pg/ml, P=0.05) and FGF21 (LRT: 133 ± 34 vs HRT: 63.5 ± 13 pg/ml, P=0.08) were higher in LRT than HRT. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The expression differences of SPARC, FGF9, BMP4, NOGGIN, and type I collagen were analyzed by RT-qPCR. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Heather Joseph, Executive Director of SPARC, contributes to our Tenth Anniversary PLOS Biology Collection by discussing how the Open Access movement has grown up.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The upregulation of VEGFA and GRN and the downregulation of SPARC and IGFBP7 are closely associated with directional metastasis to lymph nodes in EOC cells.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the current study, we used a microarray approach to identify genes that are regulated by α3β1 in immortalized keratinocytes. α3β1-responsive genes included several that are involved in extracellular matrix proteolysis or remodeling, including fibulin-2 and SPARC. However, α3β1-dependent induction of specific target genes was influenced by the genetic lesion that triggered immortalization, as α3β1-dependent fibulin-2 expression occurred in cells immortalized by either SV40 large T antigen or p53-null mutation, while α3β1-dependent SPARC expression occurred only in the former cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In a review of the literature, it was found that a total of 38 studies were published between 1995 and 2014 that reported on eight tension-free retropubic sling kits: SPARC, RetroArc, Align, Advantage, Lynx, Desara, Supris, and Gynecare TVT. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The profiled circulating tumour cells also expressed elevated levels of stem cell markers, and the extracellular matrix protein, SPARC. The expression of SPARC might correspond to an epithelial-mesenchymal transition in pancreatic circulating tumour cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Expression of mRNA for SPARC, hevin, TnC, TSP-1, -2 and -4, CCN1 and 5, periostin and OPN but not TnN was significantly upregulated in RV of MCT (2 weeks)-treated rats. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Importantly, after penetrating the BBB, this system can take advantage of the overexpression of the SPARC and mannose receptors on TAM2, thus also targeting the protumor TAM2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Of these proteins, secreted protein acidic and rich in cysteine (SPARC) and proenkephalin (PENK) were significantly decreased in the CSF of patients with DLBCL, which appeared to be correlated with CNS involvement. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Ki67 and PHH3 synergized as proliferation markers (ρ = 0.54), while SPARC expression was positively correlated with HA content (ρ = 0.37). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found that the expression of SPARC, COL6A3, and FBN1 correlated positively with infiltration levels of six immune cells in the tumors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Each osteomimetic marker harbored prognostic value in the pan-cancer analyses [SPARC: hazard ratio (HR) = 1.10, p = 0.028; SPP1: HR = 1.25, p < 0.001; BGLAP: HR = 1.13, p = 0.005]. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestational diabetes (GDM) has not been fully investigated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Combined measurements of mRNA and protein expression in single cells enable in-depth analysis of cellular states. We present SPARC, an approach that combines single-cell RNA-sequencing with proximity extension essays to simultaneously measure global mRNA and 89 intracellular proteins in individual cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A Multiplex assay was used to assess the level of various osteogenic molecules namely osteoactivin, Syndecan, osteoprotegerin (OPG) and osteonectin/SPARC. Our data shows elevated levels of Osteoactivin, Syndecan, OPG and SPARC in T2D as compared to ND individuals (p ≤ 0.05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso