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481por Karolak, Justyna A., Ginter-Matuszewska, Barbara, Tomela, Katarzyna, Kabza, Michal, Nowak-Malczewska, Dorota M., Rydzanicz, Malgorzata, Polakowski, Piotr, Szaflik, Jacek P., Gajecka, Marzena“…The most downregulated transcripts in KTCN corneas were CTGF, TGFB3, ZNF469, COL5A2, SMAD7, and SPARC, while TGFBI and SLC4A11 were the most upregulated ones. …”
Publicado 2020
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482por Caronni, Antonio, Arcuri, Pietro, Carpinella, Ilaria, Marzegan, Alberto, Lencioni, Tiziana, Ramella, Marina, Crippa, Alessandro, Anastasi, Denise, Rabuffetti, Marco, Ferrarin, Maurizio, Castagna, Anna“…After taking into account the different amplitude and speed, SPARC-derived (but not jerk-derived) indices showed reduced smoothness in patients rotating away-dystonia (1.48, 1.35–1.61) compared to controls (1.88, 1.72–2.03; P < 0.001). …”
Publicado 2022
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483“…The expression of THBS2 in CAVD and normal samples and the levels of THBS2, osteocalcin, Runx2, SPARC, COL1A2, COL1A1, SPP1, CTGF, MMP-2, MMP-13, Akt, p-Akt, p65, p-p65, and nuclear p65 in VICs were tested by qRT-PCR and Western blot. …”
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484por Pérez-Mies, Belén, Caniego-Casas, Tamara, Bardi, Tommaso, Carretero-Barrio, Irene, Benito, Amparo, García-Cosío, Mónica, González-García, Irene, Pizarro, David, Rosas, Marta, Cristóbal, Eva, Ruano, Yolanda, Garrido, María Concepción, Rigual-Bobillo, Juan, de Pablo, Raúl, Galán, Juan Carlos, Pestaña, David, Palacios, José“…By immunohistochemistry, pathological fibroblasts (pFBs), with CTHRC1 and SPARC expression, increased in areas of proliferative DAD and decreased in areas of mature fibrosis. …”
Publicado 2022
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485por Yue, Lin, Chen, Shuchun, Ren, Qingjuan, Niu, Shu, Pan, Xiaoyu, Chen, Xing, Li, Zelin, Chen, Xiaoyi“…The most obvious changes of extracellular matrix associated proteins in the three experimental groups were Coll5a1, Lama4, Sparc. CONCLUSION: Semaglutide may protect vascular structure and improve endothelial permeability by reducing the levels of Coll5a1, Lama4, Sparc in extracellular matrix, so as to improve vascular function and achieve vascular protection.…”
Publicado 2022
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486por Kauser, Sana, Mughees, Mohd, Mangangcha, Irengbam Rocky, Swami, Sanskriti, Wajid, Saima“…RESULTS: Analysis by GENT2 revealed 22 signature DEPs with the most significant change in their expression regulation, namely, gelsolin, alpha-fetoprotein, complement component C3, C7, histone H2B type 1-K, histone H2A.Z, H2AX, heat shock cognate 71 kDa protein, heat shock 70 kDa protein 1-like, cytochrome c somatic, GTP-binding nuclear protein Ran, tubulin beta chain, tubulin alpha-1B chain, tubulin alpha-1C chain, phosphoglycerate mutase 1, kininogen 1, carboxypeptidase N catalytic chain, fibulin-1, peroxiredoxins 4, lactate dehydrogenase C, SPARC, and SPARC-like protein 1. Correlation analysis between their mRNA expressions versus immune cell infiltrates showed a positive correlation with antitumor immune response elicited by these NPs as well as a correlation with drug response shown by the GDSC and CTRP drugs in different cancer cells. …”
Publicado 2023
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487por Sharma, Srilakshmi M, Choi, Dongseok, Planck, Stephen R, Harrington, Christina A, Austin, Carrie R, Lewis, Jinnell A, Diebel, Tessa N, Martin, Tammy M, Smith, Justine R, Rosenbaum, James T“…CONCLUSIONS: Our observations are the first to implicate SPARC, SLPI, and NLRP2, a component of the innate immune system, in the pathogenesis of SpA. …”
Publicado 2009
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488por Muhammad, Sani Ismaila, Maznah, Ismail, Mahmud, Rozi, Zuki, Abu Bakar Zakaria, Imam, Mustapha Umar“…RESULTS: The results indicate that groups treated with GABA (100 and 200 mg/kg) showed significant upregulation of SPARC, calcitonin receptor, and BMP-2 genes (P < 0.05), while the ORZ-treated group (100 and 200 mg/kg) revealed significant (P < 0.05) upregulation of Osx, Postn, RUNX-2, and Col1&2. …”
Publicado 2013
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489por Noorani, Lubna, Stenzel, Martina, Liang, Roger, Pourgholami, Mohammad H, Morris, David L“…The expression of VEGF and SPARC was also reduced, which indicates the underlying therapeutic mechanism of the ABZ. …”
Publicado 2015
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490Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistancepor Galimov, Artur, Hartung, Angelika, Trepp, Roman, Mader, Alexander, Flück, Martin, Linke, Axel, Blüher, Matthias, Christ, Emanuel, Krützfeldt, Jan“…PTEN, COL3A1, FSTL1, SERPINH1, and SPARC are endogenous miR-29a targets in human myotubes. …”
Publicado 2015
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491por Song, Jing, Wang, Wenqing, Wang, Yingyan, Qin, Yongxin, Wang, Yingzi, Zhou, Jian, Wang, Xuelian, Zhang, Yi, Wang, Qi“…The identified early EMT hallmark genes GALNT6, SPARC and HES7and miR-3613 provide new markers and therapeutic targets for LUAD for the further clinical diagnosis and drug screening. …”
Publicado 2019
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492por Hutchinson, Kelly Ann, Mohammad, Shuhiba, Garneau, Léa, McInnis, Kurt, Aguer, Céline, Adamo, Kristi B.“…IL-6 was analyzed using a high-sensitivity assay, while FGF21, EPO, BDNF, Fractalkine, IL-15, SPARC, FABP-3, FSTL-1, and oncostatin were analyzed using various multiplex assays. …”
Publicado 2019
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493“…Therefore, SPARC, DCN, FBN1, WWTR1, TAGLN, DDX28 and CSDC2 may contribute to the development of early-onset CRC and may serve as potential diagnostic biomarkers.…”
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494“…Furthermore, the survival analysis indicate that GC patients with a high expression of the following 9 hub DEGs, namely, BGN, COL1A1, COL1A2, FBN1, FN1, SPARC, SPP1, TIMP1, and UBE2C, had significantly worse overall survival. …”
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495por Iozon, Sofia, Caracostea, Gabriela Valentina, Páll, Emőke, Şoriţău, Olga, Mănăloiu, Ionuţ Daniel, Bulboacă, Adriana-Elena, Lupşe, Mihaela, Mihu, Carmen Mihaela, Roman, Alexandra Livia“…Some expression of secreted protein acidic and cysteine rich (SPARC) and collagen 1 alpha (COL1A) was observed for all the gMSCs regardless of the culture medium composition. gMSCs grown in 10% iPRF had significantly lower SPARC expression. …”
Publicado 2020
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496por Mantini, Giulia, Meijer, Laura L., Glogovitis, Ilias, In ‘t Veld, Sjors G. J. G., Paleckyte, Rosita, Capula, Mjriam, Le Large, Tessa Y. S., Morelli, Luca, Pham, Thang V., Piersma, Sander R., Frampton, Adam E., Jimenez, Connie R., Kazemier, Geert, Koppers-Lalic, Danijela, Wurdinger, Thomas, Giovannetti, Elisa“…Remarkably, correlation analyses revealed a negative regulation on SPARC transcription by isomiRs involved in cancer signaling, suggesting a specific ”education” in PDAC platelets. …”
Publicado 2020
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497por Wolf, Julian, Hajdu, Rozina Ida, Boneva, Stefaniya, Schlecht, Anja, Lapp, Thabo, Wacker, Katrin, Agostini, Hansjürgen, Reinhard, Thomas, Auw-Hädrich, Claudia, Schlunck, Günther, Lange, Clemens“…Among the most pterygia-specific factors were transcripts such as AHNAK, RTN4, TPT1, FSTL1, and SPARC. Immunohistochemical validation of SPARC revealed a significantly increased stromal immunoreactivity in pterygia when compared to controls, most notably in vessels and intravascular vessel wall-adherent mononuclear cells. …”
Publicado 2022
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498por Olek, Robert A., Samborowska, Emilia, Wisniewski, Piotr, Wojtkiewicz, Pawel, Wochna, Krystian, Zielinski, Jacek“…Moreover, plasma TMAO and serum SPARC levels were higher in the LC group than the corresponding postintervention values in the PLA group (p < 0.001 and p = 0.030, respectively). …”
Publicado 2023
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499“…OBJECTIVE: The aim of this study was to investigate whether Osteonectin/Secreted protein acidic and rich in cysteine (ON/SPARC) had a two-way dose-dependent regulatory effect on osteoblast mineralization and its molecular mechanism. …”
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500por Ahi, Ehsan Pashay, Kapralova, Kalina Hristova, Pálsson, Arnar, Maier, Valerie Helene, Gudbrandsson, Jóhannes, Snorrason, Sigurdur S, Jónsson, Zophonías O, Franzdóttir, Sigrídur Rut“…Following up on our previous findings that Mmp2 and Sparc were differentially expressed between morphotypes, we identified a network of genes with conserved coexpression across diverse vertebrate species. …”
Publicado 2014
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