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561por Martin, Victor, Bettencourt, Ana Francisca, Santos, Catarina, Fernandes, Maria Helena, Gomes, Pedro Sousa“…Osteogenic gene expression and ALP activity supported the osteoinduction by TCs, demonstrating significant increases in ALP levels and the upregulation of RUNX2, SP7, and SPARC genes. Minocycline and sarecycline exhibited the most potent osteogenic induction, comparable to conventional osteogenic inducers. …”
Publicado 2023
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562por Sato, Hiromu, Adachi, Noritaka, Kondo, Satomi, Kitayama, Chiyo, Tokita, Masayoshi“…Here, we analyzed embryos of three turtle species with varying degrees of temporal emargination and identified shared widespread coexpression of upstream osteogenic genes Msx2 and Runx2 and species-specific expression of more downstream osteogenic genes Sp7 and Sparc in the head. Further analysis of representative amniote embryos revealed differential expression patterns of osteogenic genes in the temporal region, suggesting that the spatiotemporal regulation of Msx2, Runx2, and Sp7 distinguishes the temporal skull morphology among amniotes. …”
Publicado 2023
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563“…OBJECTIVES: Complications of polypropylene pubovaginal tension-free tape slings (TVT, SPARC, and others), such as erosion into the bladder or chronic pain attributed to the mesh sling are rare events; however, when they occur, it may necessitate removal of the sling. …”
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564por Giagounidis, Aristoteles, Mufti, Ghulam J., Fenaux, Pierre, Germing, Ulrich, List, Alan, MacBeth, Kyle J.“…Advances in the understanding of the pathogenesis of the disease have suggested that lenalidomide targets aberrant signaling pathways caused by haplosufficiency of specific genes in a commonly deleted region on chromosome 5 (e.g., SPARC, RPS14, Cdc25C, and PP2A). As a result, the agent specifically targets del(5q) clones while also promoting erythropoiesis and repopulation of the bone marrow in normal cells. …”
Publicado 2013
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565por Lohberger, Birgit, Kaltenegger, Heike, Stuendl, Nicole, Payer, Michael, Rinner, Beate, Leithner, Andreas“…Reverse transcription quantitative real-time PCR revealed that 10% continuous cyclic strain (0.5 Hz) for 7 and 14 days induced a significant increase in the mRNA expression of the osteogenesis-specific markers type-I collagen (Col1A1), osteonectin (SPARC), bone morphogenetic protein 2 (BMP2), osteopontin (SPP1), and osteocalcin (BGLAP) in osteogenic differentiated MSPCs. …”
Publicado 2014
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566por Ting, David T., Wittner, Ben S., Ligorio, Matteo, Jordan, Nicole Vincent, Shah, Ajay M., Miyamoto, David T., Aceto, Nicola, Bersani, Francesca, Brannigan, Brian W., Xega, Kristina, Ciciliano, Jordan C., Zhu, Huili, MacKenzie, Olivia C., Trautwein, Julie, Arora, Kshitij S., Shahid, Mohammad, Ellis, Haley L., Qu, Na, Bardeesy, Nabeel, Rivera, Miguel N., Deshpande, Vikram, Ferrone, Cristina R., Kapur, Ravi, Ramaswamy, Sridhar, Shioda, Toshi, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.“…Mouse as well as human pancreatic CTCs exhibit a very high expression of stromal-derived extracellular matrix (ECM) proteins, including SPARC, whose knockdown in cancer cells suppresses cell migration and invasiveness. …”
Publicado 2014
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567por Movva, Sujana, Wen, Wenhsiang, Chen, Wangjuh, Millis, Sherri Z., Gatalica, Zoran, Reddy, Sandeep, von Mehren, Margaret, Van Tine, Brian A.“…There was overexpression or loss of other sarcoma relevant proteins such as SPARC, PTEN and MGMT. Approximately 50% of the sarcomas expressed PD-L1 by IHC and presented with PD-1+ TILs, notably the LMS, chondrosarcomas, liposarcomas and UPS. …”
Publicado 2015
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568por Nygård, Ingvild Engdal, Mortensen, Kim Erlend, Hedegaard, Jakob, Conley, Lene Nagstrup, Bendixen, Christian, Sveinbjørnsson, Baldur, Revhaug, Arthur“…Secreted protein acidic and rich in cysteine (SPARC) and collagen 1, alpha 2 (COL1A2) were both upregulated in the early phase of liver regeneration, validated by immunopositive cells during the remodelling phase of liver regeneration. …”
Publicado 2015
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569por Gaston, Joel D., Bischel, Lauren L., Fitzgerald, Lisa A., Cusick, Kathleen D., Ringeisen, Bradley R., Pirlo, Russell K.“…The traditional model had higher expression of genes associated with extracellular matrix-associated proteins, including SPARC and COL4A1. Overall, the results demonstrate that the BP coculture model is more representative of a healthy BBB state, though both models have advantages that may be useful in disease modeling.…”
Publicado 2017
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570por Tsuda, Takeshi“…Several ECM proteins are known to modulate TGF-β signaling via cell–matrix interactions, including thrombospondins, SPARC (Secreted Protein Acidic and Rich in Cystein), tenascins, osteopontin, periostin, and fibulins. …”
Publicado 2018
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571por Luo, Hao-Lun, Chiang, Po-Huang, Huang, Chun-Chieh, Su, Yu-Li, Sung, Min-Tse, Tsai, Eing-Mei, Lin, Chang-Shen, Chiang, Po-Hui“…The secreted protein acidic and rich in cysteine-like 1 (SPARCL1) protein, belongs to the SPARC-related family of matricellular proteins. Much literature has been published describing the role of SPARCL1 in the prognosis many cancers. …”
Publicado 2019
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572Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitropor Modi, Prashant Kumar, Prabhu, Ashwini, Bhandary, Yashodhar P., Shenoy P., Sudheer, Hegde, Aparna, ES, Sindhu Priya, Johnson, Renjith P., Das, Shankar Prasad, Vazirally, Sahil, Rekha, Punchappady-Devasya“…The treatment also increased the expression of osteopontin and osteogenic genes such as collagen-1, secreted protein acidic and cysteine rich (SPARC), and osteocalcin. Calcium glucoheptonate treatment did not exert any cytotoxicity on colorectal and renal epithelial cells, indicating the safety of the treatment. …”
Publicado 2019
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573por Cioroianu, Alexandra Ioana, Stinga, Patricia Irina, Sticlaru, Liana, Cioplea, Mirela Daniela, Nichita, Luciana, Popp, Cristiana, Staniceanu, Florica“…Also, it was found that “gene expression profile” of the microenvironmental cells, the phenotype of tumor-associated macrophages (TAM), the expression of matricellular proteins like SPARC and fibronectin, the overexpression of several types of matrix metalloproteinases (MMPs) like MMP-2 and MMP-9, or the tissue inhibitors of matrix metalloproteinases (TIMPs) may lead to a favorable or adverse outcome. …”
Publicado 2019
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574por Cheng, Shuru, Wang, Xueying, Zhang, Quanwei, He, Yuqin, Zhang, Xia, Yang, Lei, Shi, Jinping“…We found 6 production-performance-related and 30 meat-quality-related DEGs through a correlation analysis, including SPARC, ACVRL1, FNDC5, and FREM1. The expression levels of 11 DEGs were validated by real-time PCR, and the results were in accordance with the results of the comparative transcriptomic and correlation analyses. …”
Publicado 2020
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575“…We showed that astroglial cells lacking Bim expression demonstrate increased VEGF expression and altered matricellular protein production including increased expression of thrombospondin-2 (TSP2), osteopontin and SPARC. Bim deficient astroglial cells also exhibited altered proliferation, migration, adhesion to various extracellular matrix proteins and increased expression of inflammatory mediators. …”
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576“…Here, we show that cholinergic neurons grown in an autaptic circuit in the absence of glia sense the loss of half of their synaptic contacts triggered by exposure to peptide p4.2, a C-terminal fragment of SPARC. Synaptic elimination is driven by a reorganization of the periodic F-actin cytoskeleton present along neurites, and occurs without altering the density of postsynaptic receptors. …”
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577“…HFD-induced obesity led to upregulated expression of extracellular matrix (ECM) genes (Col3a1, Col6a3, Eln, and Sparc) and downregulated expression of immunoregulatory genes (Iigp1 and Cxcl10) in these stromal subtype cells. …”
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578por Malcor, Jean-Daniel, Hunter, Emma J, Davidenko, Natalia, Bax, Daniel V, Cameron, Ruth, Best, Serena, Sinha, Sanjay, Farndale, Richard W“…These are ligands for collagen-binding cell-surface receptors (integrins or discoidin domain receptors) or secreted proteins (SPARC and von Willebrand factor). THPs enhanced HUVEC adhesion, spreading and proliferation on 2D collagen films. …”
Publicado 2020
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579por Li, Jiawei, Jiang, Huiming, Lv, Zhongyang, Sun, Ziying, Cheng, Chaoqun, Tan, Guihua, Wang, Maochun, Liu, Anlong, Sun, Heng, Guo, Hu, Chen, Fufei, Liu, Zizheng, Fei, Yuxiang, Liu, Yuan, Wu, Rui, Xu, Xingquan, Yan, Wenjin, Jiang, Qing, Shi, Dongquan“…Moreover, the mechanism of fibrocartilage hyalinization by microtubule stabilization was verified as the inhibition of Sparc (secreted protein acidic and rich in cysteine). …”
Publicado 2022
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580por Wang, Rui, Liu, Xixi, Li, Li, Yang, Ming, Yong, Jun, Zhai, Fan, Wen, Lu, Yan, Liying, Qiao, Jie, Tang, Fuchou“…Clustering analysis of testes and ovaries revealed several novel cell subsets, including POU5F1(+)SPARC(+) FGCs and KRT19(+) somatic cells. Furthermore, our data indicated that the bone morphogenetic protein (BMP) signaling pathway plays cell type-specific and developmental stage-specific roles in testis development and promotes the gonocyte-to-spermatogonium transition (GST) in late-stage testicular mitotic arrest FGCs. …”
Publicado 2022
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