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581“…RNA sequencing indicated that MAP4K4 affected the transcription of SPARC, ADAM19, GPX7, GNG2, and COLA1. Interestingly, the phenotype of inhibiting JNK phosphorylation by SP600125 was similar to MAP4K4 knockdown. …”
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582“…Furthermore, the differential expression of hub genes in various cell populations between the acute myocardial infarction (AMI) and sham-operation groups was analyzed by processing scRNA data (E-MTAB-7376 from the ArrayExpress database) and RNA-seq data (GSE183168). (3) Results: Ten strongly interlinked hub genes (Timp1, Sparc, Spp1, Tgfb1, Decr1, Vim, Serpine1, Serpina3n, Thbs2, and Vcan) were identified by the construction of a protein–protein interaction network from 135 differentially expressed genes identified through comprehensive bioinformatics analysis and their reliability was verified using GSE119857. …”
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583“…Hub genes includingCOL1A2, FN1, BGN, THBS2, COL5A2, COL6A3, SPARC and COL12A1 wereidentified. The top interactive miRNAs including miR-29a-3p, miR-101-3p,miR-183-5p, and miR-15a-5p targeted the most hub genes. …”
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584Publicado 1988“…In contrast, the synthesis of SPARC (secreted protein acidic rich in cysteine/osteonectin was stimulated approximately two-fold by TGF-beta, but only in fibroblastic populations. …”
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585“…Four candidate genes were identified within the region, namely SPARC [Secreted protein, acidic, cysteine-rich (osteonectin)], SLC36A1 (Solute Carrier 36 family A1), SLC36A2 (Solute Carrier 36 family A2), and SLC36A3 (Solute Carrier 36 family A3). …”
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586por Yonehara, Keisuke, Ishikane, Hiroshi, Sakuta, Hiraki, Shintani, Takafumi, Nakamura-Yonehara, Kayo, Kamiji, Nilton L., Usui, Shiro, Noda, Masaharu“…We recently generated a knock-in mouse in which SPIG1 (SPARC-related protein containing immunoglobulin domains 1)-expressing cells are visualized with GFP, and found that retinal ganglion cells projecting to the medial terminal nucleus (MTN), the principal nucleus of the AOS, are comprised of SPIG1(+) and SPIG1(−) ganglion cells distributed in distinct mosaic patterns in the retina. …”
Publicado 2009
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587por Zhong, Jun, Krawczyk, Sarah A., Chaerkady, Raghothama, Huang, Hailiang, Goel, Renu, Bader, Joel S., Wong, G. William, Corkey, Barbara E., Pandey, Akhilesh“…They include collagen triple helix repeat containing 1, cytokine receptor-like factor 1, glypican-1, hepatoma-derived growth factor, SPARC related modular calcium binding protein 1, SPOCK 1, and sushi repeat-containing protein. …”
Publicado 2010
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588por Wikman, Harriet, Westphal, Laura, Schmid, Felicitas, Pollari, Sirkku, Kropidlowski, Jolanthe, Sielaff-Frimpong, Bettina, Glatzel, Markus, Matschke, Jakob, Westphal, Manfred, Iljin, Kristiina, Huhtala, Heini, Terracciano, Luigi, Kallioniemi, Anne, Sauter, Guido, Müller, Volkmar, Witzel, Isabell, Lamszus, Katrin, Kemming, Dirk, Pantel, Klaus“…The expression of five genes, CADM1, SPARC, RECK, TNFAIP3 and CXCL14, which were also found down-regulated in gene expression profiling analyses of BCBM tissue samples, was verified by qRT-PCR in a larger patient cohort. …”
Publicado 2014
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589por DiTommaso, Tia, Jones, Lynelle K., Cottle, Denny L., Gerdin, Anna-Karin, Vancollie, Valerie E., Watt, Fiona M., Ramirez-Solis, Ramiro, Bradley, Allan, Steel, Karen P., Sundberg, John P., White, Jacqueline K., Smyth, Ian M.“…Many of these were not previously associated with skin disease in the organ (Mysm1, Vangl1, Trpc4ap, Nom1, Sparc, Farp2, and Prkab1), while others were ascribed new cutaneous functions on the basis of the screening approach (Krt76, Lrig1, Myo5a, Nsun2, and Nf1). …”
Publicado 2014
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590por Takigawa, Hidehiko, Kitadai, Yasuhiko, Shinagawa, Kei, Yuge, Ryo, Higashi, Yukihito, Tanaka, Shinji, Yasui, Wataru, Chayama, Kazuaki“…Expression of epithelial-mesenchymal transition (EMT)–related genes such as fibronectin (FN), SPARC, and galectin 1 was increased by direct coculture with MSCs. …”
Publicado 2017
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591por Uzan, Jennifer, Laas, Enora, Abd Alsamad, Issam, Skalli, Dounia, Mansouri, Dhouha, Haddad, Bassam, Touboul, Cyril“…Immunohistochemistry (IHC) study was performed on type I EC tumor samples using five adipokines (SPARC, RBP4 (Retinol Binding Protein 4), adiponectin, TNF α, IL-6) and hormonal receptors (estrogen receptor and progesterone receptor). …”
Publicado 2017
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592por Huang, Xu-Qiong, Zhou, Zi-Qi, Zhang, Xiao-Fei, Chen, Chang-Long, Tang, Yan, Zhu, Qian, Zhang, Jian-Hua, Xia, Jian-Chuan“…Secreted modular calcium binding protein-2 (SMOC2), a recently identified matricellular protein that belongs to the SPARC protein family, has been reported to be downregulated in various cancers. …”
Publicado 2017
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593“…The hub network analysis showed that the signal transmission chain FN1→SPARC→COL1A1→MMP2 is the key regulatory pathway for extracellular signal transmission. …”
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594por Sidlauskaite, Eva, Gibson, Jack W., Megson, Ian L., Whitfield, Philip D., Tovmasyan, Artak, Batinic-Haberle, Ines, Murphy, Michael P., Moult, Peter R., Cobley, James N.“…Regardless of whether it was achieved with muscle (α-bungarotoxin), nerve (α-latrotoxin) targeted neurotoxins or an endogenous pruning cue (SPARC), synaptic inactivity increased mitochondrial ROS in vivo. …”
Publicado 2018
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595por Baird, Arabella, Lindsay, Timothy, Everett, Alice, Iyemere, Valentine, Paterson, Yasmin Z., McClellan, Alyce, Henson, Frances M. D., Guest, Deborah J.“…Here we show that equine iPSCs cultured for 21 days in osteogenic induction media on an OsteoAssay surface upregulate the expression of osteoblast associated genes and proteins, including COL1A1, SPARC, SPP1, IBSP, RUNX2 and BGALP. We also demonstrate that iPSC-osteoblasts are able to produce a mineralised matrix with both calcium and hydroxyapatite deposition. …”
Publicado 2018
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596por Hauptman, Nina, Boštjančič, Emanuela, Žlajpah, Margareta, Ranković, Branislava, Zidar, Nina“…We have identified 16 genes with differential expression in carcinoma compared to adenoma: COL12A1, COL1A2, COL3A1, DCN, PLAU, SPARC, SPON2, SPP1, SULF1, FADS1, G0S2, EPHA4, KIAA1324, L1TD1, PCKS1, and C11orf96. …”
Publicado 2018
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597por Yu, Runhong, Zhang, Jingyu, Zang, Yuzhu, Zeng, Li, Zuo, Wenli, Bai, Yanliang, Liu, Yanhui, Sun, Kai, Liu, Yufeng“…Furthermore, four selected proteins, namely LRG1, S100A8, SPARC and sL-selectin, were verified by ELISA. These results were consistent with the results of the proteomics analysis. …”
Publicado 2019
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598por Chen, Mei-Ling, Ho, Cheng-Ju, Yeh, Chung-Min, Chen, Sung-Lang, Sung, Wen-Wei, Wang, Shao-Chuan, Chen, Chih-Jung“…Our goal was to evaluate the clinical role of SPARC (secreted protein acidic and cysteine rich, osteonectin), cwcv, and kazal-like domains’ proteoglycan 1 (SPOCK1) in PCa. …”
Publicado 2019
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599por Haeggblom, Linnea, Ährlund‐Richter, Andreas, Mirzaie, Leila, Farrajota Neves da Silva, Pedro, Ursu, Ramona G., Ramqvist, Torbjörn, Näsman, Anders“…Lastly, significant differences in protein expression was confirmed for SPARC, psoriasin, type I collagen and galectin‐1 in both HPV(+) and HPV(−) tumors. …”
Publicado 2019
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600por Dai, Bai, Hao, Fei, Xu, Teng, Zhu, Bing, Ren, Li-Qing, Han, Xiao-Yu, Liu, Dong-Jun“…Through comprehensive analysis, we selected Thymosin β4 (Tβ4), Rho GTPase activating protein 6 (ARHGAP6), ADAM metallopeptidase with thrombospondin type 1 motif 15, (ADAMTS15), Chordin (CHRD), and SPARC (Osteonectin), cwcv and kazal-like domains proteoglycan 1 (SPOCK1) as candidate genes. …”
Publicado 2020
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