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Mostrando 601 - 620 Resultados de 956 Para Buscar '"SPARC"', tiempo de consulta: 0.13s Limitar resultados
  1. 601
    “…The oncogenic role of SPARC/osteonectin, cwcv, and kazal-like domain proteoglycan 1 (SPOCK1) has been demonstrated in several cancers, however, the clinical and functional significance of SPOCK1 in PTC are largely unknown. …”
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    MON-536 SPOCK1 Promotes the Progression of Papillary Thyroid Cancer ViaPI3K/Akt Signaling Activation
  2. 602
    “…The aim of this review is to summarize the effects of several adipokines, including leptin, diponectin, resistin, chemerin, lipocalin-2 (LCN2), vaspin, omentin, follistatin-like 1 (FSTL1), secreted protein acidic and rich in cysteine (SPARC), secreted frizzled-related protein 5 (SFRP5), C1q/TNF-related proteins (CTRPs), family with sequence similarity to 19 member A5 (FAM19A5), wingless-type inducible signaling pathway protein-1 (WISP1), progranulin (PGRN), nesfatin-1 (nesfatin), visfatin/PBEF/NAMPT, apelin, retinol binding protein 4 (RPB4), and plasminogen activator inhibitor-1 (PAI-1) in the regulation of insulin resistance and vascular function, as well as many aspects of inflammation and immunity and their potential role in managing obesity-associated diseases, including metabolic, osteoarticular, and cardiovascular diseases.…”
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    Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases
  3. 603
    “…The LBB is a system-of-systems integrating research feasibility databases in i2b2, a real-time clinical data warehouse, and an informatics system for institutional research services management (SPARC). LBB delivers deidentified clinical data and laboratory specimens. …”
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    Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank
  4. 604
    “…We demonstrated that GILT could directly reduce the noncollagenous bone matrix protein SPARC, and additionally, enhance collagen degradation by cathepsin K. …”
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    A non-immunological role for γ-interferon–inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption
  5. 605
    “…Recently, metrics that quantify motion smoothness such as log dimensionless jerk (LDLJ) and spectral arc length (SPARC) are increasingly being applied in medical simulators. …”
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    Motion Smoothness Metrics for Cannulation Skill Assessment: What Factors Matter?
  6. 606
    por Han, Jie, Rong, Yihui, Gao, Xudong
    Publicado 2021
    “…OBJECTIVE: To investigate SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 (SPOCK1) gene expression across The Cancer Genome Atlas (TCGA) cancers, both in cancer versus normal tissues and in different stages across the cancer types. …”
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    Multiomic analysis of the function of SPOCK1 across cancers: an integrated bioinformatics approach
  7. 607
    “…Metformin, on the contrary, suppressed the expression of sparc, integrin αV, fibronectin and N-cadherin with the reduced cell motility. …”
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    Antitumor Effect of Metformin in Combination with Binimetinib on Melanoma Cells
  8. 608
    “…Using a powerful EMTome to investigate EMT gene signature, we identified a panel of EMT genes COL5A2, ITGAV, SPARC and ACTA2 in MESO. In combination with TCGA database, Timer2.0 and other resources, we observed that overexpression of these emerging genes is positively correlated with immunosuppressive infiltration, and an unfavorable factor to patient survival in MESO. …”
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    A panel of emerging EMT genes identified in malignant mesothelioma
  9. 609
    “…Proteins involved in integrin signaling (Ras-RAP1b, TLN and FN) and SLIT-ROBO pathways (PFN1, CAPR1, PSMA5) as well as extracellular matrix proteins (SERPINH1, SPARC, ITGβ1, CRTAP) showed enhanced expression in corneal fibroblasts and myofibroblasts compared to keratocytes, indicating their possible role in wound healing. …”
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    Quantitative Proteomics Reveals Molecular Network Driving Stromal Cell Differentiation: Implications for Corneal Wound Healing
  10. 610
    “…A DNA methylation signature (n = 44) was deduced from microarray experiments and confirmed by quantitative methylation-specific PCR (qMSP) and by MSRE-qPCR, providing for six genes’ single areas under the curve (AUC) values of >0.85 (WT1, PENK, SPARC, GDNF, TMEFF2, DCC). A subset of the signatures can be used for patient stratification and therapy monitoring for progressed CRC with liver metastasis using cfDNA. …”
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    Multiplexed DNA Methylation Analysis in Colorectal Cancer Using Liquid Biopsy and Its Diagnostic and Predictive Value
  11. 611
    “…The lactoferrin modification and endogenous albumin adsorption contribute a dual-targeting effect on the receptors of both LRP-1 and SPARC that were overexpressed in tumor cells and immune cells (e.g., tumor-associated macrophages). …”
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    Remodeling “cold” tumor immune microenvironment via epigenetic-based therapy using targeted liposomes with in situ formed albumin corona
  12. 612
    “…For example, obesity is associated with elevated levels of pro-inflammatory adipokines (e.g., leptin, resistin, chemerin, progranulin, RBP4, WISP1, FABP4, PAI-1, Follistatin-like1, MCP-1, SPARC, SPARCL1, and SAA) and reduced levels of anti-inflammatory adipokines such as adiponectin, omentin, ZAG, SFRP5, CTRP3, vaspin, and IL-10. …”
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    Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation
  13. 613
    “…Particle accelerators and high energy physics (HEP) have been and are the main core of the LNF research activity, but like other HEP international laboratories also LNF is now moving in the direction of developing a dedicated free electron laser (FEL) user facility, EuPRAXIA@SPARC_Lab, based on plasma acceleration. This new facility in the framework of the EuPRAXIA (European Plasma Research Accelerator with eXcellence in Applications) EU project should produce FEL radiation beams for a wide range of applications using a smaller accelerator compared to actual radio frequency-based accelerator sources dimensions.…”
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    The INFN-LNF present and future accelerator-based light facilities
  14. 614
    “…More recently, they have been found altered in animal models of psychiatric disorders such as drug addiction. Hevin (also known as Sparc-like 1) is a matricellular protein highly expressed in the adult brain that has been implicated in resilience to stress, suggesting a role in motivated behaviors. …”
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    The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder
  15. 615
    “…The transcriptomic analysis revealed that CYP27A1 KO led to differential expression of multiple genes, including ELANE, LY6C2, S100A9, GM20708, BGN, SPARC, and COL1A2, which were confirmed by qRT-PCR and Western blot. …”
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    CYP27A1 deficiency promoted osteoclast differentiation
  16. 616
    Publicado 1993
    Tabla de Contenidos: “…Extracellular matrix molecules and their receptors -- Proteoglycans -- Aggrecan -- Agrin -- Biglycan (BGN) -- Bone sialoprotein (BSP) -- Cartilage matrix protein (CMP) -- Cat-301 proteoglycan -- CD44 -- Cholinesterases -- Collagens -- Basement membrane collagens (type IV) -- FACIT collagens (types IX, XII, XIV) -- Fibrillar collagens (types I-III, V, XI) -- Other collagens (types VI, VII, XIII) -- Short chain collagens (types VIII, X) -- Decorin (DCN) -- Elastin -- Fibrinogen/fibrin -- Fibroglycan -- Fibromodulin -- Fibronectins -- Fibulin --Glypican -- HB-GAM -- Hyaluronan and hyaluronan binding proteins (hyaladherins) -- J1 glycoproteins (janusin) -- Laminin -- Laminin binding proteins (LBP, CBP 35) -- Link protein -- Mucins -- Nidogen/entactin -- Osteopontin/secreted phosphoprotein (OPN/SPP) -- Perlecan -- Plasminogen -- Plasminogen activator inhibitor 1 (PAI-1) -- Plasminogen activator inhibitor 2 (PAI-2) -- Proteins containing Ca{esc}p2{esc}s*-dependent carbohydrate recognition domains (CRDs) -- Restrictin -- Serglycin -- SPARC/osteonectin -- Syndecan -- Tenascin.…”
    Libro
    Guidebook to the extracellular matrix and adhesion proteins /
  17. 617
    “…MESO EMT genes such as COL5A2, ITGAV, SERPINH1, CALD1, SPARC, and ACTA2 were associated with upregulation of TGF-β signaling, hedgehog signaling, and IL-2-STAT5 signaling and downregulation of the IFN-α and IFN-γ response. …”
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    Prognostic Value of EMT Gene Signature in Malignant Mesothelioma
  18. 618
    “…Results: The MSLN, SPP1, THBS2, SPARC, FN1, IGFBP7, VCAN were up-regulated in gastric carcinoma samples, while FGA was down-regulated. …”
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    Joint effect of THBS2 and VCAN accelerating the poor prognosis of gastric cancer
  19. 619
    “…Furthermore, our results demonstrated that the SPARC, ATP6V0D2, IL4I1, SMPDL3A, ADAM7, TMCC3, ULK2, MYO6, THG1L and IRG1 genes were the most significantly expressed genes in the commercial birds and the PAPPA, DUSP1, PSMD12, LHX8, IL8, TRPM2, GDAP1L1, FAM161A, ABCC2 and ASAH2 genes were the most significant in the indigenous chickens. …”
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    RNA-Seq Profiling between Commercial and Indigenous Iranian Chickens Highlights Differences in Innate Immune Gene Expression
  20. 620
    “…Here, we show apabetalone downregulated HRMC activation with TGF-β1 stimulation by suppressing TGF-β1-induced α-smooth muscle actin (α-SMA) expression, α-SMA assembly into stress fibers, enhanced contraction, collagen overproduction, and expression of key drivers of fibrosis, inflammation, or calcification including thrombospondin, fibronectin, periostin, SPARC, interleukin 6, and alkaline phosphatase. Lipopolysaccharide-stimulated expression of inflammatory genes IL6, IL1B, and PTGS2 was also suppressed. …”
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    Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment
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