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681por Seol, Min-A, Chu, In-Sun, Lee, Mi-Jin, Yu, Goung-Ran, Cui, Xiang-Dan, Cho, Baik-Hwan, Ahn, Eun-Kyung, Leem, Sun-Hee, Kim, In-Hee, Kim, Dae-Ghon“…Expression of SPP1, EFNB2, E2F2, IRX3, PTTG1, PPARγ, KRT17, UCHL1, IGFBP7 and SPARC proteins was immunohistochemically verified in human and hamster CC tissues. …”
Publicado 2011
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682“…Further analysis of EpCAM positive but RT-PCR negative cell fractions showed that they had increased expression of MMPs, repressors of E-cadherin, SPARC and vimentin, all transcripts associated with the process of epithelial to mesenchymal transition. …”
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683por Orr, B, Riddick, A C P, Stewart, G D, Anderson, R A, Franco, O E, Hayward, S W, Thomson, A A“…We demonstrated that ASPN, CAV1, CFH, CTSK, DCN, FBLN1, FHL1, FN, NKTR, OGN, PARVA, S100A6, SPARC, STC1 and ZEB1 proteins showed specific and varied expression patterns in fetal human prostate and in prostate cancer. …”
Publicado 2012
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684“…Inos affected anticipatory activity preceding lights-off, suggesting a possible clock-dependent function. BM-40-SPARC, U2af50 and fax affected peak activity at dawn without affecting anticipation or overall inactivity (proportion of 15-min intervals without activity), suggesting that these effects may depend on the day-night light cycle. …”
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685“…METHODS: Real-time reverse transcription-polymerase chain reaction was used to detect the expression levels of KAP1, TIMP1, STC2, talin 2 (TLN2), sushi-repeat-containing protein, X-linked 2 (SRPX2) and secreted protein, acidic, cysteine-rich (SPARC) in the patients’ peripheral blood karyocytes. …”
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686por Li, Jun, Xin, Jiaojiao, Zhang, Liyuan, Wu, Jian, Jiang, Longyan, Zhou, Qian, Li, Jun, Guo, Jing, Cao, Hongcui, Li, Lanjuan“…Among the genes with more than 20-fold higher expression in HPCs were a progenitor marker (CD90), a pentraxin-related gene (PTX3), collagen proteins (COL5A2, COL1A1 and COL4A2), cytokines (EGF and PDGFD), metabolic enzymes (CYBRD1, BCAT1, TIMP2 and PAM), a secreted protein (SPARC) and an endothelial protein C receptor (PROCR). …”
Publicado 2013
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687por Iacob, Eli, Light, Kathleen C, Tadler, Scott C, Weeks, Howard R, White, Andrea T, Hughen, Ronald W, VanHaitsma, Timothy A, Bushnell, Lowry, Light, Alan R“…BPD patients showed increased APP, CREB1, NFKB1, NR3C1, and SPARC and decreased TNF expression. Depression severity was related to increased IL-10, P2RY1, P2RX1, and TRPV4 expression. …”
Publicado 2013
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688por Yun, Hongmin, Lathrop, Kira L., Yang, Enzhi, Sun, Ming, Kagemann, Larry, Fu, Valeria, Stolz, Donna B., Schuman, Joel S., Du, Yiqin“…CD45+ inflammatory cells invaded the TM within 1 week. The expression of SPARC was increased in the TM from 1 to 12 weeks. …”
Publicado 2014
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689por Wollaston-Hayden, Edith E., Harris, Ruth B. S., Liu, Bingqiang, Bridger, Robert, Xu, Ying, Wells, Lance“…Furthermore, we show that the LPL and SPARC promoters are enriched for Sp1 and O-GlcNAc modified proteins during insulin resistance in adipocytes. …”
Publicado 2015
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690por Forrester, Steven J., Kawata, Keisuke, Lee, Hojun, Kim, Ji‐Seok, Sebzda, Kelly, Butler, Tiffiny, Yingling, Vanessa R., Park, Joon‐Young“…GEO dataset analysis identified BMP5, COL1A2, CTGF, MGP, MMP2, and SPARC as potential targets for further processing. …”
Publicado 2014
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691por Laxman, Navya, Rubin, Carl-Johan, Mallmin, Hans, Nilsson, Olle, Pastinen, Tomi, Grundberg, Elin, Kindmark, Andreas“…Functional studies by overexpression and knockdown of miRNAs showed that, the differentially expressed miRNAs hsa-miR-29b, hsa-miR-30c2, and hsa-miR-125b target genes highly relevant to bone metabolism, e.g., collagen, type I, α1 (COL1A1), osteonectin (SPARC), Runt-related transcription factor 2 (RUNX2), osteocalcin (BGLAP), and frizzled-related protein (FRZB). …”
Publicado 2015
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692High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cellspor Chen, Yu-Ching, Statt, Sarah, Wu, Reen, Chang, Hao-Teng, Liao, Jiunn-Wang, Wang, Chien-Neng, Shyu, Woei-Cherng, Lee, Chen-Chen“…The top five upregulated genes were SNAI2, FGFBP1, VIM, SPARC (osteonectin), and SERPINE1, while the downregulated genes included OCLN, TJP1 (ZO-1), FZD7, CDH1 (E-cadherin), and LAMA5. …”
Publicado 2016
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693por Tam, C S, Power, J E, Markovic, T P, Yee, C, Morsch, M, McLennan, S V, Twigg, S M“…Genes related to ECM structure (COL1, COL3, COL6A2, SPARC), growth factors (TGFB1, TGFB2, CTGF, VEGF) and muscle function (DMD (Dp147), CPN3, DAG1) were measured in gastrocnemius muscle using real-time PCR and COL1, 3 and 6 protein were measured by western immunoblot. …”
Publicado 2015
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694por Pashay Ahi, Ehsan, Walker, Benjamin S., Lassiter, Christopher S., Jónsson, Zophonías O.“…We found E(2) mediated differential expression of genes involved in extracellular matrix (ECM) remodelling, mmp2/9/13, sparc and timp2a, as well as components of skeletogenic pathways, bmp2a, erf, ptch1/2, rankl, rarab and sfrp1a. …”
Publicado 2016
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695por Chen, Qi, Yao, Yuan-ting, Xu, Huan, Chen, Yan-bo, Gu, Meng, Cai, Zhi-kang, Wang, Zhong“…Molecular mechanisms that underlie this malignancy remain obscure, and this study investigated the role of SPARC/osteonectin, cwcv, and kazal-like domain proteoglycan 1 (SPOCK1) in prostate cancer progression. …”
Publicado 2016
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696“…Two of the most associated genes identified by the haplotype method were FPGT (p = 6.7 × 10(− 8)) on chromosome 1 and SPARC (p = 3.3 × 10(− 7)) on chromosome 5. Both genes were previously implicated in blood pressure regulation and hypertension. …”
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697por Wang, Yan“…Functional enrichment showed SPARC, MMP17, and COL6A3 were related to extracellular matrix. …”
Publicado 2017
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698“…These included 4 genes encoding extracellular matrix proteins; collagen III α1, secreted acidic cysteine-rich glycoprotein (SPARC), biglycan and nidogen-1 (entactin). Immunohistochemistry confirmed increased collagen III and biglycan protein expression in IL11Ra(-/-) uterus at this time. …”
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699por Wang, Siqi, Jin, Feng, Fan, Wenliang, Liu, Fang, Zou, Yan, Hu, Xuehan, Xu, Haibo, Han, Ping“…Further immunohistochemical validation revealed that MTHFD2 and SPARC were positively expressed in DLGG, whereas RBP4 was positively expressed in NG. …”
Publicado 2017
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700por Samsonraj, Rebekah M., Dudakovic, Amel, Manzar, Bushra, Sen, Buer, Dietz, Allan B., Cool, Simon M., Rubin, Janet, van Wijnen, Andre J.“…We show that CytoD, which may function by redistributing the intracellular location of β‐actin (ACTB), is a potent osteogenic stimulant as reflected by significant increases in alkaline phosphatase activity, extracellular matrix mineralization, and osteoblast‐related gene expression (e.g., RUNX2, ALPL, SPARC, and TGFB3). RNA sequencing analyses of MSCs revealed that acute CytoD treatment (24 hours) stimulates a broad program of osteogenic biomarkers and epigenetic regulators. …”
Publicado 2017
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