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Mostrando 761 - 780 Resultados de 956 Para Buscar '"SPARC"', tiempo de consulta: 0.16s Limitar resultados
  1. 761
    “…Ten hub genes (COL1A1, COL3A1, COL1A2, COL5A2, FN1, THBS1, COL5A1, SPARC, COL18A1, and COL11A1) were identified via PPI network analysis. …”
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    Identification of Key Genes and Circular RNAs in Human Gastric Cancer
  2. 762
    “…We identified genomic gains in osteoblast mimicry genes including gains of ALPL, osteopontin, SPARC, OB-cadherin and loss of RUNX2, and validated genomic alterations or increased expression at the DNA and RNA level in an independent cohort of 45 men with bone-metastatic CRPC and in 150 metastatic biopsies from men with mCRPC. …”
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    Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer
  3. 763
    “…Transcriptome sequencing revealed that fasting itself, but not the following refeeding, induced a prominent upregulation of a variety of pro-angiogenic genes, including SMOC1 (SPARC related modular calcium binding 1) and SCG2 (secretogranin II). …”
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    Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2
  4. 764
    “…The top 10 hub genes were FN1, COL1A2, SPARC, COL3A1, CTGF, LUM, TIMP1, THBS2, COL5A2, and TGFB1. …”
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    Analysis of key genes and pathways associated with the pathogenesis of intervertebral disc degeneration
  5. 765
    “…Besides, some new therapeutic targets and mechanisms (MAGI2-AS3-SPARC/GJA1/CYSLTR1, DLG5-AS1-DEFB1, and RHPN1-AS1-CDC45/ORC) were also revealed. …”
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    Coexpression Network Analysis Identifies a Novel Nine-RNA Signature to Improve Prognostic Prediction for Prostate Cancer Patients
  6. 766
    “…EMT transcription factors HOXC6 and HMGA2 were identified as upstream regulator of TS, and AXL, SPARC and FOSL1 as downstream effectors. TS knock-down reduced the metastatic colonisation in vivo. …”
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    Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer
  7. 767
    “…Airway remodeling proteins included: MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, TIMP-2, EGF, Angiopoietin-2, G-CSF, BMP-9, Endoglin, Endothelin-1, Leptin, FGF-1, Follistatin, HGF, HB-EGF, PLGF, VEGF-A, VEGF-C, VEGF-D, FGF-2, TGF-β1, TGF-β2, TGF-β3, PDGF AA, PDGF BB, SPARC, Periostin, OPN, and TGF-α. Results: A total of 43 young children comprising RV cases (n = 26) and uninfected controls (n = 17) were included. …”
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    Airway Remodeling Factors During Early-Life Rhinovirus Infection and the Effect of Premature Birth
  8. 768
    “…RESULTS: SIM capably quantified clear morphological and granular changes in platelets stimulated with proteinase‐activated receptor 1 (PAR‐1) activating peptide and revealed a large intra‐ and interdonor variability in VWF‐positive object numbers within healthy resting platelets, similar to variation in secreted protein acidic and rich in cysteine (SPARC). We subsequently characterized VWD platelets to identify changes in the α‐granule compartment of patients with different VWF defects, and were able to stratify two patients with type 3 VWD rising from different pathological mechanisms. …”
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    Quantitative 3D microscopy highlights altered von Willebrand factor α‐granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms
  9. 769
    “…RESULTS: The in-depth transcriptional and single-cell protein analysis of diabetic RNV tissue samples revealed an accumulation of endothelial cells, macrophages and myofibroblasts as well as an abundance of secreted ECM proteins such as SPARC, FN1 and several types of collagen in RNV tissue. …”
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    In-Depth Molecular Characterization of Neovascular Membranes Suggests a Role for Hyalocyte-to-Myofibroblast Transdifferentiation in Proliferative Diabetic Retinopathy
  10. 770
    “…By the machine learning, we constructed a scoring system termed as senescore based on six signature genes: ADH1B, IL1A, SERPINE1, SPARC, EZH2, and TNFAIP2. Higher senescore demonstrated robustly predictive capability for longer overall and recurrence-free survival in 2290 gastric cancer samples, which was independently validated by the multiplex staining analysis of gastric cancer samples on the tissue microarray. …”
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    Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer
  11. 771
    “…NFKBIA, FN1, FAP, KANK4, COMP, FAM101B, COL1A2, ANKRD1, TAGLN, SPARC, ADAM19, OLFM4, CXCL10/11, OASL, FOS, APOBEC3A, IFI44L, IFI27, IFIT1, RSAD2, NDUFS1, SRSF6, HECTD1, CBX3, and DDX17 are among the genes that may be impacted by infection, according to our findings. …”
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    Global Gene Expression and Docking Profiling of COVID-19 Infection
  12. 772
    “…CONFLICT OF INTEREST: This project was planned and executed by the authors on behalf of SPARC (Student Psychiatry Audit and Research Collaborative). …”
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    Dementia patients have greater anti-cholinergic drug burden on discharge from hospital: A multicentre cross-sectional study
  13. 773
    “…Seven genes (GATA1 (adjusted P‐value = 5.57 × 10(−4)), TLN1 (adjusted P‐value = 9.40 × 10(−4)), GP1BA (adjusted P‐value = 2.15 × 10(−2)), SELP (adjusted P‐value = 2.29 × 10(−2)), MPL (adjusted P‐value = 1.20 × 10(−2)), F13A1 (adjusted P‐value = 1.39 × 10(−2)) and SPARC (adjusted P‐value = 4.06 × 10(−2))) were significantly downregulated in severe anaphylaxis patients who did not receive adrenaline before ED arrival, compared with healthy controls. …”
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    Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans
  14. 774
    “…Our results indicate that SPOCK1 may serve as a therapeutic target and could be utilized for monitoring ovarian cancer. ABSTRACT: Purpose: Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) has been found in a variety of malignant tumors and is associated with a poor prognosis. …”
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    SPOCK1 Overexpression Suggests Poor Prognosis of Ovarian Cancer
  15. 775
    “…Together, these analyses validated and prioritized several key genes mis-expressed in Celf1(cKO) lenses that are relevant to lens biology, including known cataract-linked genes (e.g., Cryab, Cryba2, Cryba4, Crybb1, Crybb2, Cryga, Crygb, Crygc, Crygd, Cryge, Crygf, Dnase2b, Bfsp1, Gja3, Pxdn, Sparc, Tdrd7, etc.) as well as novel candidates (e.g., Ell2 and Prdm16). …”
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    High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology
  16. 776
    “…Among these, a subset of inflammation-related proteins including fibrinogen-β and -γ chains (FGB and FGG), phospholipase A2 (PLA2G2A) and SPARC was significantly downregulated in the presence of Aquamin(®) (alone and in combination with LPS-cytokines); another subset of proteins with anti-inflammatory, antioxidant or anti-microbial activity was upregulated by Aquamin(®) treatment. …”
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    A multi-mineral intervention to counter pro-inflammatory activity and to improve the barrier in human colon organoids
  17. 777
    “…A protein–protein interaction network of the 133 genes was constructed using the STRING database, and the cytoHubba plug-in of Cytoscape was used to hub genes were screen out 11 hub genes, including MMP14, VTN, COL15A1, COL6A2, SPARC, COL5A1, COL6A3, COL6A1, COL8A2, ADAMTS2 and COL7A1. …”
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    Identification and analysis of RNA-5-methylcytosine-related key genes in osteoarthritis
  18. 778
    “…Buffalo Smoc-1 was found to encode a secreted matricellular glycoprotein containing two EF-hand calcium binding motifs homologous to that of BM-40/SPARC family. In buffalo, this single copy gene consisted of 12 exons and was mapped onto the acrocentric chromosome 11. …”
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    Characterization of Smoc-1 uncovers two transcript variants showing differential tissue and age specific expression in Bubalus bubalis
  19. 779
    “…In addition, Runx2 has the potential to regulate the transcription of extracellular matrix modulators such as SPARC and MMP1, thereby influencing the tumour microenvironment.…”
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    Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer
  20. 780
    “…Upregulated genes in POAG LC cells included, transforming growth factor beta 1 (TGFβ1), secreted acid protein cysteine rich (SPARC), periostin (POSTN), thrombospondin-1 (THBS1), cartilage linking protein-1 (CRTL-1), and collagen type I (COL1A1), collagen type V (COL5A1), and collagen type XI (COL11A1). …”
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    Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells
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