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141por Mateo, Francesca, Meca-Cortés, Óscar, Celià-Terrassa, Toni, Fernández, Yolanda, Abasolo, Ibane, Sánchez-Cid, Lourdes, Bermudo, Raquel, Sagasta, Amaia, Rodríguez-Carunchio, Leonardo, Pons, Mònica, Cánovas, Verónica, Marín-Aguilera, Mercedes, Mengual, Lourdes, Alcaraz, Antonio, Schwartz, Simó, Mellado, Begoña, Aguilera, Kristina Y, Brekken, Rolf, Fernández, Pedro L, Paciucci, Rosanna, Thomson, Timothy M“…Of these, the protein most abundantly secreted in S relative to M cells was SPARC. Immunodepletion of SPARC inhibited the enhanced invasiveness of M induced by S conditioned medium. …”
Publicado 2014
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142por Etz, Rebecca S, Keith, Rosalind E, Maternick, Anna M, Stein, Karen L, Sabo, Roy T, Hayes, Melissa S, Sevak, Purvi, Holland, John, Crosson, Jesse C“…METHODS: SPARC is a two-armed randomized controlled trial (RCT) of 30 primary care practices in the Virginia Ambulatory Care Outcomes Research Network (ACORN). …”
Publicado 2015
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143por Morrissey, Meghan A., Jayadev, Ranjay, Miley, Ginger R., Blebea, Catherine A., Chi, Qiuyi, Ihara, Shinji, Sherwood, David R.“…Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. …”
Publicado 2016
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144“…BACKGROUND: SPARC is a matricellular protein involved in cell-matrix interactions. …”
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145por Rosset, Emilie Moore, Trombetta-eSilva, Jessica, Hepfer, Glenn, Yao, Hai, Bradshaw, Amy Dodd“…Secreted protein acidic and rich in cysteine (SPARC) is a collagen-binding matricellular protein known to influence collagen fiber assembly in the PDL. …”
Publicado 2017
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146“…Here, we investigated whether the astrocyte-derived factors hevin and SPARC, known to regulate excitatory synapse development, have altered expression in FXS. …”
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147por Mazzolini, Guillermo, Atorrasagasti, Catalina, Onorato, Agostina, Peixoto, Estanislao, Schlattjan, Martin, Sowa, Jan-Peter, Sydor, Svenja, Gerken, Guido, Canbay, Ali“…Contribution of SPARC accumulation to disease severity is largely unknown in NAFLD. …”
Publicado 2018
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148“…The object was to evaluate the potential effect of miR-211 and verify its influence on the function of secreted protein acidic and rich in cysteine (SPARC) in cervical cancer. It was demonstrated that miR-211 was downregulated in cervical cancer cell lines (HeLa and C33A) and cervical cancer specimens, while SPARC expression level was higher in tumor tissues. …”
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149por Liao, Ping, Li, Wei, Liu, Ruizheng, Teer, Jamie K, Xu, Biaobo, Zhang, Wei, Li, Xi, Mcleod, Howard L, He, Yijing“…The investigations of SERPINE1 and SPARC may promote their predictive and prognostic value in GC.…”
Publicado 2018
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150por Okura, Yuu, Imao, Takeshi, Murashima, Seisuke, Shibata, Haruki, Kamikavwa, Akihiro, Okamatsu-Ogura, Yuko, Saito, Masayuki, Kimura, Kazuhiro“…Although SPARC enhances nerve growth factor (NGF)-dependent neurogenesis, the physical interaction of NGFβ with adiponectin and SPARC remains obscure. …”
Publicado 2019
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151por Wirthschaft, Peter, Bode, Julia, Soni, Himanshu, Dietrich, Fabio, Krüwel, Thomas, Fischer, Bernd, Knobbe-Thomsen, Christiane B., Rossetti, Giulia, Hentschel, Andreas, Mack, Norman, Schönig, Kai, Breckwoldt, Michael O., Schmandke, André, Pusch, Stefan, Medenbach, Jan, Bendszus, Martin, Schwab, Martin E., von Deimling, Andreas, Kool, Marcel, Herold-Mende, Christel, Reifenberger, Guido, Ahrends, Robert, Tews, Björn“…SPARC depletion reduces tumor dissemination that significantly prolongs survival and improves response to cytostatic therapy. …”
Publicado 2019
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152por Yu, Ling, Zheng, Yuxi, Liu, Brian J., Kang, Min Hyung, Millar, J. Cameron, Rhee, Douglas J.“…We hypothesized that the lower IOP previously observed in SPARC -/- mice is due to a greater outflow facility. …”
Publicado 2020
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153“…SPARC is a secreted glycoprotein that plays a complex and multifaceted role in tumour formation and progression. …”
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154“…This enhancement mainly relied on upregulating the expression of SPARC through downregulating methylation of the SPARC gene. …”
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156por Mendieta, Cindy V., de Vries, Esther, Calvache, Jose Andrés, Ahmedzai, Sam H., Prue, Gillian, McConnell, Tracey, Reid, Joanne“…SPARC was recently validated in Colombian Spanish (SPARC-Sp) but has not yet been implemented in clinical practice. …”
Publicado 2023
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157Publicado 1990“…One of these sites also contributes to the affinity of SPARC for extracellular matrix components. Peptides representing subregions of SPARC were synthesized and antipeptide antibodies were produced. …”
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158por Seet, Li-Fong, Su, Roseline, Barathi, V. A., Lee, Wing Sum, Poh, Rebekah, Heng, Yee Meng, Manser, Ed, Vithana, Eranga N., Aung, Tin, Weaver, Matt, Sage, E. Helene, Wong, Tina T.“…In this study, we investigated post-operative surgical wound survival in an experimental glaucoma filtration model in SPARC-null mice. Loss of SPARC resulted in a marked (87.5%) surgical wound survival rate compared to 0% in wild-type (WT) counterparts. …”
Publicado 2010
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160por Bhoopathi, Praveen, Gorantla, Bharathi, Sailaja, G. S., Gondi, Christopher S., Gujrati, Meena, Klopfenstein, Jeffrey D., Rao, Jasti S.“…Secreted protein acidic and rich in cysteine (SPARC) is also known as BM-40 or Osteonectin, a multi-functional protein modulating cell–cell and cell–matrix interactions. …”
Publicado 2012
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