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Mostrando 161 - 180 Resultados de 956 Para Buscar '"SPARC"', tiempo de consulta: 0.15s Limitar resultados
  1. 161
    “…By mean of a genetic approach we herein provide evidence from different in vivo liver disease models suggesting a profibrogenic role for SPARC. METHODS: Two in vivo models of liver fibrosis, based on TAA administration and bile duct ligation, were developed on SPARC wild-type (SPARC(+/+)) and knock-out (SPARC(−/−)) mice. …”
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    Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice
  2. 162
    “…To understand the mechanisms of SPARC deficiency in delaying subconjunctival fibrosis, we used the gene silencing approach to reduce SPARC expression in HTFs and examined parameters important for wound repair and fibrosis. …”
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    In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon’s fibroblasts: comparisons with mitomycin C
  3. 163
    “…In particular, it was found an aberrant expression of matricellular glycoprotein SPARC. SPARC is involved in normal tissue remodeling, regulating the deposition of extracellular matrix, but also in neoplastic transformation. …”
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    Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
  4. 164
    por van der Wall, E. E.
    Publicado 2014
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    Cost analysis favours SPECT over PET and CTA for evaluation of coronary artery disease: the SPARC study
  5. 165
    “…Among factors co-expressed by stromal elements within these different specialized niches, we identified the pleiotropic matricellular protein secreted protein acidic and rich in cysteine (SPARC). The actual role of stromal SPARC in normal B-cell lymphopoiesis, investigated in Sparc(−/−) mice and BM chimeras retaining the Sparc(−/−) genotype in host stroma, demonstrated defective BM and splenic B-cell lymphopoiesis. …”
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    Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies
  6. 166
    “…Ectopic expression of miR-211 effectively suppressed HCC cell proliferation, migration and invasion both in vitro and in vivo. We identified SPARC as a bona fide target of miR-211, and overexpression of miR-211 decreased the mRNA and protein expression of SPARC. …”
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    MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma
  7. 167
    “…SPARC expression positively correlated with the proliferation marker Ki-67 suggesting a role for SPARC in cerebrovascular development. …”
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    SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties
  8. 168
    “…Secreted protein acidic and rich in cysteine (SPARC) binds to albumin, suggesting that SPARC plays an important role in tumor uptake of nab-paclitaxel. …”
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    SPARC is a possible predictive marker for albumin-bound paclitaxel in non-small-cell lung cancer
  9. 169
    “…SPARC also induces mitochondrial Δψ collapse in SK-N-BE(2) and NB1691 neuroblastoma cells.…”
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    SPARC overexpression suppresses radiation-induced HSP27 and induces the collapse of mitochondrial Δψ in neuroblastoma cells
  10. 170
    “…BACKGROUND: We aimed to investigate the cellular source of secreted protein acidic and rich in cysteine (SPARC) in gastric cancer tissues and the relationship between SPARC expression and its prognostic significance. …”
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    The relationship between stromal cell derived SPARC in human gastric cancer tissue and its clinicopathologic significance
  11. 171
    “…We then investigated the effect of SPARC treatment on neuronal health in an injury context where SPARC expression is upregulated. …”
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    SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury
  12. 172
    “…METHODS: Kras(G12D);p48-Cre;SPARC(−/−) (KC-SPARC(−/−)) and Kras(G12D);p48-Cre;SPARC(WT) (KC-SPARC(WT)) were generated and analysed at different stages of carcinogenesis by histological grading, immunohistochemistry for epithelial and stromal markers, survival and preclinical analysis. …”
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    SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer
  13. 173
    “…A significant relative risk reduction (RNTCP = NTCP(SPArc)/NTCP(vIMPT)) for organs at risk (OARs) was obtained with SPArc ranging from 0.61 to 0.86 depending on the clinical endpoint. …”
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    Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy
  14. 174
    “…SPARC-deficient mice have been shown to exhibit impaired glucose tolerance and insulin secretion, but the underlying mechanism remains unknown. …”
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    SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells
  15. 175
    “…The Stereotactic Prostate Augmented Radiotherapy with Cyberknife (SPARC) trial was designed to determine the feasibility of a focal boost defined with multiparametric magnetic resonance imaging (mpMRI) using stereotactic ablative body radiotherapy (SABR). …”
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    Stereotactic radiotherapy with focal boost for intermediate and high-risk prostate cancer: Initial results of the SPARC trial
  16. 176
    “…After the first version of the Korean SPARC (K-SPARC) was developed, back-translation into English was performed by a professional translator and bilingual oncologist. …”
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    Pilot study for the Psychometric Validation of the Sheffield Profile for Assessment and Referral to Care (SPARC) in Korean Cancer Patients
  17. 177
    “…Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein involved in the extracellular matrix and interactions between cells during neural development of the central nervous system (CNS). …”
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    SPARC Knockdown Reduces Glutamate-Induced HT22 Hippocampal Nerve Cell Damage by Regulating Autophagy
  18. 178
    “…In addition, secreted protein acidic and rich in cysteine (SPARC) was identified as a target of miR-592 in CRC. …”
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    MicroRNA-592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC
  19. 179
    “…Fluorescence in situ hybridization (FISH) was used to analyze the location of circSPARC. Function-based experiments were performed using circSPARC knockdown and overexpression cell lines in vitro and in vivo, including CCK8, colony formation, transwell and metastasis models. …”
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    The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway
  20. 180
    Materias:
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    High Gradient Test of a C-Band Accelerating Structure Prototype for Energy Upgrade of Frascati Photoinjector SPARC
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