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2por Enault, Sébastien, Muñoz, David, Simion, Paul, Ventéo, Stéphanie, Sire, Jean-Yves, Marcellini, Sylvain, Debiais-Thibaud, Mélanie“…Our phylogenetic analyses reveal that the single chondrichthyan SPARC-L gene is co-orthologous to the osteichthyan SPARC-L1 and SPARC-L2 paralogues. …”
Publicado 2018
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3“…Herein we discuss mechanisms underlying the inhibitory effect of SPARC on adipogenesis. SPARC enhances the Wnt/β-catenin signaling pathway and regulates the expression and posttranslational modification of collagen. …”
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4“…CONCLUSIONS—: The data implicate SPARC in the noncell autonomous control of cardiac function in Drosophila and suggest that modulation of SPARC gene expression may ameliorate cardiac dysfunction in humans.…”
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5por Romero, Adrian, Leurs, Nicolas, Muñoz, David, Debiais-Thibaud, Mélanie, Marcellini, Sylvain“…While cartilage is an ancient tissue found both in protostomes and deuterostomes, its mineralization evolved more recently, within the vertebrate lineage. SPARC, SPARC-L, and the SCPP members (Secretory Calcium-binding PhosphoProtein genes which evolved from SPARC-L) are major players of dentine and bone mineralization, but their involvement in the emergence of the vertebrate mineralized cartilage remains unclear. …”
Publicado 2021
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7“…The SPARC gene plays multiple roles in extracellular matrix synthesis and cell shaping, associated with tumor cell migration, invasion, and metastasis. …”
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8por Bradshaw, Amy D.“…SPARC is a collagen-binding matricellular protein. …”
Publicado 2009
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9“…Although many clinical studies have found a correlation of SPARC expression with malignant progression and patient survival, the mechanisms for SPARC function in tumorigenesis and metastasis remain elusive. …”
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10“…SPARC is a matricellular protein; meaning SPARC is secreted into the extracellular space but does not serve a structural function. …”
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13por Suzuki, M, Hao, C, Takahashi, T, Shigematsu, H, Shivapurkar, N, Sathyanarayana, U G, Iizasa, T, Fujisawa, T, Hiroshima, K, Gazdar, A F“…SPARC (secreted protein acidic and rich in cysteine) is an extracellular Ca(2+)-binding matricellular glycoprotein associated with the regulation of cell adhesion and growth. …”
Publicado 2005
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14por Suzuki, M, Hao, C, Takahashi, T, Shigematsu, H, Shivapurkar, N, Sathyanarayana, U G, Iizasa, T, Fujisawa, T, Hiroshima, K, Gazdar, A FEnlace del recurso
Publicado 2013
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15por Said, Neveen“…Secreted Protein Acidic and Rich in Cysteine (SPARC) is a matricellular glycoprotein that is implicated in myriad physiological and pathological conditions characterized by extensive remodeling and plasticity. …”
Publicado 2016
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16por Naczki, Christine, John, Bincy, Patel, Chirayu, Lafferty, Ashlyn, Ghoneum, Alia, Afify, Hesham, White, Michael, Davis, Amanda, Jin, Guangxu, Kridel, Steven, Said, Neveen“…In this respect, we investigated the role of Secreted Protein Acidic and Rich in Cysteine (SPARC) in metabolic plasticity of OvCa. We used a syngeneic model of OvCa in Sparc-deficient and proficient mice to gain comprehensive insight into the paracrine effect of stromal-SPARC in metabolic programming of OvCa in the peritoneal milieu. …”
Publicado 2018
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17“…SPARC facilitates the generation of plausible hypotheses regarding underlying biochemical mechanisms by structurally characterizing protein sequence constraints. …”
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18“…MIP101, RKO, HCT 116, and HT-29 CRC cell lines were also used to evaluate the effect of 5-Aza on: SPARC promoter methylation, SPARC expression, the interaction between DNMT1 and the SPARC promoter (ChIP assay), cell viability, apoptosis, and cell proliferation. …”
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